The Gordon Research Conference (GRC) on Genomic Instability is designed to address both the fundamental mechanisms and translational impact of the cellular pathways that maintain genome stability. Genomic instability contributes to the development of many human diseases, such as cancer, neurodegeneration, and premature ageing. This conference will present the latest research on the molecular causes of genomic instability in various human diseases, ranging from DNA replication defects to R-loop biogenesis. We will also cover the cutting-edge findings of DNA repair and DNA damage signaling pathways, their roles in counteracting different forms of genomic instability, and their deficiencies in human diseases. Furthermore, we will hear new strategies that exploit genomic instability of human diseases, bringing the findings of basic research to disease therapy. This GRC thus provides broad coverage of the field of Genomic Instability with a speaker line-up of leading scientists. In addition to top-notch invited speakers, each session will include several selected talks from submitted abstracts. The Genomic Instability GRC will be preceded by a Gordon Research Seminar for trainees on August 1-2, 2020.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 15, 2019. Please check back for updates.
- Keynote Session: New Frontiers in the DNA Damage Response
- Repair of Chromosome Breaks
- DNA Replication and Replication Stress
- Transcription, R-Loops and DNA Repair
- Chromatin Dynamics and Epigenetic Regulation of DNA Repair
- Genomic Instability and DNA Repair During the Cell Cycle
- DNA Repair and Genomics
- Emerging DNA Repair Pathways
- DNA Repair Defects and Diseases