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Glycobiology

Gordon Research Conference

The Biological Role of Glycans as Key Regulators of Life

March 23 - 28, 2025

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Glycobiology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The exponential structural diversity of glycoconjugates makes them crucial carriers of biological information and key mediators of interaction at cellular and organism level. The Glycobiology GRC will unite researchers across disciplines and enable them to discuss, learn and challenge our current knowledge on all aspects of glycobiology. This includes, but is not limited to, understanding the biosynthesis and evolution of glycans, their complex roles in signaling and immunity, their involvement in a wide spectrum of diseases or the emerging new technologies that become available to study their structure and function. Translational achievements and developments in the domains of glycobiotechnology, and glycoinformatics and novel avenues for artificial intelligence that have the potential to transform glycosciences will also be explored.

The Glycobiology GRC is preceded by the Glycobiology Gordon Research Seminar (GRS) that is specifically catering to provide graduate students and early career researchers with a platform to present their exciting research, receive career advice and benefit from the experience of invited established researchers in a safe and welcoming environment.

Related Meeting

This GRC will be held in conjunction with the "Glycobiology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Interdisciplinary Glycosciences Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"Glycobiology of Host-Microbe Interactions in the Gut"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Plasmodium falciparum Invasion Complex Protein CyRPA Targets Sialic Acid Glycans to Invade Erythrocytes; A New Opportunity for the Prevention and Treatment of Malaria"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"In Situ Computational Microscopy of Viruses and their Glycoproteins: Challenges and Opportunities"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Building the Complexity of Glycome in the View of Evolution Discussion Leaders: and
9:00 am - 9:20 am	"Structural Insights into Catalysis and Inhibition of Oligosaccharyltransferase Enzymes"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Beyond the Sequon: Modulation of N-Glycosylation Site Occupancy"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Structural Basis for the Synthesis of High-Mannose N-Glycans in the Endoplasmic Reticulum"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Molecular Insight into Chondroitin Sulfate Polymerase Complexes"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Protein O-Mannosylation in Actinobacteria - An Enigmatic Post-Translational Modification"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Embracing the Complexity of Glycobiology: More Data, More Problems?"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Identification of a Mammalian Protease Capable of Degrading Bulky Components of the Glycocalyx"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Signalling and Glycoimmunity Discussion Leader:
6:00 pm - 6:20 pm	"Development and Application of Glycomimetics to Study the Role of C-Type Lectins in Immunity"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"The Sialic Acid-Siglec Axis in the Cancer-Immunity Cycle"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Siglec-Glycan Interactions in Immune Regulation"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Molecular Recognition of Glycans by Siglecs and Siglec-Like Adhesins"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Quantifying Glycoprotein-Ligand Interactions by Native Mass Spectrometry: Challenges and New Technologies"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Glycan in Infection: Glycobiology of Toxins, Microbes and Parasites Discussion Leaders: and
9:00 am - 9:20 am	"A Glycan-Based Strategy to Tackle the Global Urgent Threat of Multi-Drug Resistant Bacteria"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Immune Regulation Mediated by Protein-Carbohydrate Interactions"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"O-Linked Protein Glycosylation: A Defense Mechanism for Pathogenic Neisseria"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Carbohydrate-Mediated “Innate” Considerations in Designing Vaccine-Candidates Against S. Pneumoniae and N. Meningitidis"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Exploiting Pathogen Immune Evasion Strategies in the Design of Vaccines and Therapeutics"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Lipopolysaccharides from Microbiota: "Fantastic Structures and Where to Find Them""
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Investigation of Protein-Glycan Recognition In Vivo using DNA-Encoded Liquid Glycan Array (LiGA) and Liquid Lectin Array (LiLA)"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Glycosylation Disorders and Cancer Discussion Leader:
6:00 pm - 6:20 pm	"Exploring Glycan Heterogeneity in the Tumor Microenvironment: A Path Towards Single-Cell and Integrative Solutions"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Insights into the Lipidic Secrets of N-Glycosylation"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Glycoproteomics of Complex Cancer Environments: New Frontier for Biomarker Discovery?"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Interplay Between Protein O-Mannosylation and N-Glycosylation Pathways in Integrin ß1 Maturation"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Studying Glycosylation in Inflammatory Bowel Disease Using State-of-the-Art Glycoanalytics"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Glycoscience for Developing Therapeutics Discussion Leader:
9:00 am - 9:20 am	"Glycans as Triggers of Health to Chronic Inflammation Transition: Impact in Crohn's Disease Prediction"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Synthetic Single-Domain Antibodies Against the C-Type Lectin Receptor DCIR as Potential Therapeutics for Tuberculosis and Beyond"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Multimodal Spatial Omics Reveals Pro-Invasive N-Glycosylation Changes in the Human Maternal-Fetal Interface"
9:55 am - 10:00 am	Discussion
10:00 am - 10:35 am	Coffee Break
10:35 am - 10:55 am	"Glycopeptide Engineering for Next-Generation Cancer Vaccines and Diagnostics"
10:55 am - 11:05 am	Discussion
11:05 am - 11:25 am	"Targeting Clinically-Significant Respiratory Viruses and Their Glycointeractions for Drug Discovery"
11:25 am - 11:35 am	Discussion
11:35 am - 11:45 am	"Glycoengineering of CD8+ T Cell as a Novel Strategy to Enhance T Cell Anti-Tumor Therapies"
11:45 am - 11:50 am	Discussion
11:50 am - 12:00 pm	"Systemic Lupus Erythematosus Disease Course Classification from Immunoglobulin-G-Derived N-Glycans Analyzed via Bruker GlycoTyper™ Liquid Biopsy Platform"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Glycobiology of Neural Function and Diseases Discussion Leader:
6:00 pm - 6:20 pm	"Interplay Between Protein O-Mannosylation and Receptor Protein Tyrosine Phosphatases in the Nervous System: Lessons from the Drosophila Model"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Linking Glycosaminoglycan Regulation, Pattern and Function Using Developmental Models"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"The Glycobiology of Brain Calcification"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Siglec Protein Expression on Human Microglia, and Impacts on Cellular Function"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Deciphering the Neurological Puzzle in ALG13-CDG through Cortical Organoid Modeling"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Synthetic Biology and Emerging Technologies for Glycoscience Discussion Leaders: and
9:00 am - 9:20 am	"Glycomic Alterations in Breast Cancer Tissues Following Pre-operative Oral Carbohydrate Intake"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Regulation of EGF Receptor Function via Glycan-Glycan Interactions with Metastable Ganglioside Homodimers as Revealed by Single-Molecule Imaging"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Making Use of Informative Glycan-Specific Ions in Glycopeptide MS/MS Spectra"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Glyco-PAINT - Single Molecule Glycan-Lectin Binding Kinetics on Living Immune Cells"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Novel Lectin-Based Approaches to Target and Kill Cancer Cells"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Shotgun Scanning Glycomutagenesis: A Simple and Efficient Strategy for Enhancing Glycoprotein Therapeutics and Vaccines"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"PMM2-CDG in Medaka Fish: A Patient-Based Model to Investigate the Impact of Glycosylation Disorders on Embryonic Development"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Glycosaminoglycan-Mimetics: A Novel Class of Compounds for Enhancing Thrombopoiesis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Glycobioinformatics: Current Challenges and Future Opportunities for AI Integration Discussion Leader:
6:00 pm - 6:20 pm	"The Human Glycome Atlas Project: Current Status and Opportunities for Collaboration"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Predictable Structural Inhibition of N-linked Glycosylation Augments B-cell Lymphoma Disease Severity"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Taming the Complexity of Glycosylation with A.I. to Decipher and Engineer Glycoprotein Function"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Experimentally Guided Reconstruction of Glycoproteins 3D Structures with GlycoShape ReGlyco-Fit"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Sticky Shield: Exploring Respiratory Mucin Binding to the SARS-CoV-2 Spike Glycoprotein"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

University of Copenhagen - Center for Glycocalyx Research

Conference Links

Conference History Glycobiology (GRS)

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