Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Interdisciplinary Glycosciences
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Glycobiology of Host-Microbe Interactions in the Gut"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Plasmodium falciparum Invasion Complex Protein CyRPA Targets Sialic Acid Glycans to Invade Erythrocytes; A New Opportunity for the Prevention and Treatment of Malaria"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"In Situ Computational Microscopy of Viruses and their Glycoproteins: Challenges and Opportunities"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Building the Complexity of Glycome in the View of Evolution
9:00 am - 9:20 am
"Structural Insights into Catalysis and Inhibition of Oligosaccharyltransferase Enzymes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Beyond the Sequon: Modulation of N-Glycosylation Site Occupancy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Structural Basis for the Synthesis of High-Mannose N-Glycans in the Endoplasmic Reticulum"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Molecular Insight into Chondroitin Sulfate Polymerase Complexes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Protein O-Mannosylation in Actinobacteria - An Enigmatic Post-Translational Modification"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Embracing the Complexity of Glycobiology: More Data, More Problems?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identification of a Mammalian Protease Capable of Degrading Bulky Components of the Glycocalyx"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Signalling and Glycoimmunity
6:00 pm - 6:20 pm
"Development and Application of Glycomimetics to Study the Role of C-Type Lectins in Immunity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"The Sialic Acid-Siglec Axis in the Cancer-Immunity Cycle"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Siglec-Glycan Interactions in Immune Regulation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Molecular Recognition of Glycans by Siglecs and Siglec-Like Adhesins"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Quantifying Glycoprotein-Ligand Interactions by Native Mass Spectrometry: Challenges and New Technologies"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Glycan in Infection: Glycobiology of Toxins, Microbes and Parasites
9:00 am - 9:20 am
"A Glycan-Based Strategy to Tackle the Global Urgent Threat of Multi-Drug Resistant Bacteria"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Immune Regulation Mediated by Protein-Carbohydrate Interactions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"O-Linked Protein Glycosylation: A Defense Mechanism for Pathogenic Neisseria"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Carbohydrate-Mediated “Innate” Considerations in Designing Vaccine-Candidates Against S. Pneumoniae and N. Meningitidis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Exploiting Pathogen Immune Evasion Strategies in the Design of Vaccines and Therapeutics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Lipopolysaccharides from Microbiota: "Fantastic Structures and Where to Find Them ""
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Investigation of Protein-Glycan Recognition In Vivo using DNA-Encoded Liquid Glycan Array (LiGA) and Liquid Lectin Array (LiLA)"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycosylation Disorders and Cancer
6:00 pm - 6:20 pm
"Exploring Glycan Heterogeneity in the Tumor Microenvironment: A Path Towards Single-Cell and Integrative Solutions"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Insights into the Lipidic Secrets of N-Glycosylation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Glycoproteomics of Complex Cancer Environments: New Frontier for Biomarker Discovery?"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Interplay Between Protein O-Mannosylation and N-Glycosylation Pathways in Integrin ß1 Maturation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Studying Glycosylation in Inflammatory Bowel Disease Using State-of-the-Art Glycoanalytics"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycoscience for Developing Therapeutics
9:00 am - 9:20 am
"Glycans as Triggers of Health to Chronic Inflammation Transition: Impact in Crohn's Disease Prediction"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Synthetic Single-Domain Antibodies Against the C-Type Lectin Receptor DCIR as Potential Therapeutics for Tuberculosis and Beyond"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Multimodal Spatial Omics Reveals Pro-Invasive N-Glycosylation Changes in the Human Maternal-Fetal Interface"
9:55 am - 10:00 am
Discussion
10:00 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Glycopeptide Engineering for Next-Generation Cancer Vaccines and Diagnostics"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Targeting Clinically-Significant Respiratory Viruses and Their Glycointeractions for Drug Discovery"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Glycoengineering of CD8+ T Cell as a Novel Strategy to Enhance T Cell Anti-Tumor Therapies"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Systemic Lupus Erythematosus Disease Course Classification from Immunoglobulin-G-Derived N-Glycans Analyzed via Bruker GlycoTyper™ Liquid Biopsy Platform"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycobiology of Neural Function and Diseases
6:00 pm - 6:20 pm
"Interplay Between Protein O -Mannosylation and Receptor Protein Tyrosine Phosphatases in the Nervous System: Lessons from the Drosophila Model"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Linking Glycosaminoglycan Regulation, Pattern and Function Using Developmental Models"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The Glycobiology of Brain Calcification"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Siglec Protein Expression on Human Microglia, and Impacts on Cellular Function"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Deciphering the Neurological Puzzle in ALG13-CDG through Cortical Organoid Modeling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Synthetic Biology and Emerging Technologies for Glycoscience
9:00 am - 9:20 am
"Glycomic Alterations in Breast Cancer Tissues Following Pre-operative Oral Carbohydrate Intake"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of EGF Receptor Function via Glycan-Glycan Interactions with Metastable Ganglioside Homodimers as Revealed by Single-Molecule Imaging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Making Use of Informative Glycan-Specific Ions in Glycopeptide MS/MS Spectra"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Glyco-PAINT - Single Molecule Glycan-Lectin Binding Kinetics on Living Immune Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Novel Lectin-Based Approaches to Target and Kill Cancer Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Shotgun Scanning Glycomutagenesis: A Simple and Efficient Strategy for Enhancing Glycoprotein Therapeutics and Vaccines"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"PMM2-CDG in Medaka Fish: A Patient-Based Model to Investigate the Impact of Glycosylation Disorders on Embryonic Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Glycosaminoglycan-Mimetics: A Novel Class of Compounds for Enhancing Thrombopoiesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycobioinformatics: Current Challenges and Future Opportunities for AI Integration
6:00 pm - 6:20 pm
"The Human Glycome Atlas Project: Current Status and Opportunities for Collaboration"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Predictable Structural Inhibition of N-linked Glycosylation Augments B-cell Lymphoma Disease Severity"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Taming the Complexity of Glycosylation with A.I. to Decipher and Engineer Glycoprotein Function"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Experimentally Guided Reconstruction of Glycoproteins 3D Structures with GlycoShape ReGlyco-Fit"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Sticky Shield: Exploring Respiratory Mucin Binding to the SARS-CoV-2 Spike Glycoprotein"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure