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Glycobiology (GRS)

Gordon Research Seminar

Mapping the Functional Glycome in Health and Disease

March 11 - 12, 2023

Chairs Simon P. Wisnovsky and Kathirvel Alagesan

Contact Chairs

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, CA, United States

Venue and Travel Information

Conference Description

The Glycobiology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The Glycobiology GRS is a small group setting that fosters open discussion of innovative glycobiology research through formal presentation and social interaction. The seminar will include three scientific session and two poster sessions. The seminar will highlight recent progress in understanding the functional role of glycans and glycoconjugates in a range of areas including (although not limited to): cell signaling, host-pathogen interactions, immune regulation, development, genetic disease, neurobiology and cancer. Emerging methodologies for glycan synthesis, structural glycan analysis and glyco-informatics will also be discussed. The seminar will conclude with a career panel session during which mentors at various stages of their careers will share experiences and answer questions from trainees focused on professional development and other topics.

Related Meeting

This GRS will be held in conjunction with the "Glycobiology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Regulation of Glycosylation Discussion Leader: Nicholas Riley (Stanford University, United States)
3:45 pm - 4:00 pm	Andrew Alexander (ETH Zürich, Switzerland) "Structural and Functional Analysis of ALG9: a Human Endoplasmic Reticulum a1,2-Mannosyltransferase"
4:00 pm - 4:05 pm	Discussion
4:05 pm - 4:20 pm	Lola Fagbami (University of Georgia, United States) "Elucidating the Mechanism of N-linked Glycosylation in Human Malaria Parasites"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Chemical and Molecular Analysis of Glycosylation Discussion Leader: Fiona Kearns (University of California, San Diego, United States)
7:30 pm - 7:45 pm	Sarah Lowery (Yale University, United States) "Coupled MALDI-MSI and LC-MS for Comprehensive O-Glycoproteomic Analysis of FFPE Mucinous Tumor Samples"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Jessica Stark (Stanford University, United States) "Antibody-lectin Chimeras for Glyco-immune Checkpoint Blockade"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Mana Mukherjee (National Institutes of Health, United States) "1,3-Pr₂-6-OTs GlcNAlk as Bioorthogonal Precursor for Specific Labeling of N-glycan Hybrid Structure"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Jaclyn Swan (UCSD, United States) "The Sialome of the Human Retina"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Tiandi Yang (Harvard Medical School, United States) "An Extra ECM-binding Matriglycan on Dystroglycan"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Nicholas Riley (Stanford University, United States) "Deciphering O-glycoprotease Substrate Preferences with O-Pair Search"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Glycans in Health and Disease Discussion Leader: Jaclyn Swan (UCSD, United States)
9:00 am - 9:15 am	Priti Gupta (Gothenburg University, Sweden) "Effects of Estrogen on IgG Glycosylation and Total Serum Protein Glycosylation"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	Rohit Budhraja (Mayo clinic, United States) "N-glycoproteomic Profiling of Phosphoglucomutase 2 (Pgm2) Knockout Mouse Heart Reveals Distinct Glycosylation Pattern"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Beatriz Calle (Francis Crick Institute, United Kingdom) "A Chemical Biology Approach to Characterise the Glycoproteome of Breast Cancer"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Lauren Gandy (Rensselaer Polytechnic Institute, United States) "Defining the Interaction of HSV-1 Glycoprotein D and Heparan Sulfate: Implications for Alzheimer’s Disease and Herpes Viral Entry"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Fiona Kearns (University of California, San Diego, United States) "Atomic Scale Exploration of Respiratory Mucins and their Interactions with SARS-CoV-2 Spike"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	Vienvilay Phandanouvong Lozano (University of California Berkeley, United States) "Interrogating the Preferential Catabolism of Dietary Sialic Acids by the Gut Microbiota"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Careers in Glycoscience Discussion Leaders: Simon Wisnovsky (University of British Columbia, Canada)
1:30 pm - 2:30 pm	Panel Discussion Careers in Glycoscience Lance Wells (University of Georgia, United States) Daniel Kolarich (Institute for Glycomics, Griffith University, Australia) Karin Hoffmeister (Versiti Blood Research Institute, United States)
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute Of Dental & Craniofacial Research of the National Institutes of Health under Award Number R13DE032572. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

“Research reported in this publication was supported by the National Institute Of Dental & Craniofacial Research of the National Institutes of Health under Award Number R13DE032572. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."

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Conference History Glycobiology

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