Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Sphingolipids and Glycosphingolipids in Cell Biology and Disease
Session in memory of Lina Obeid.
Discussion Leaders: Maurizio Del Poeta (Stony Brook University, USA) and Yusuf Hannun (Stony Brook University, USA)
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7:40 pm - 7:55 pm |
Opening Remarks
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7:55 pm - 8:30 pm |
Sarah Spiegel (Virginia Commonwealth University, USA)
"Sphingosine-1-Phosphate: From Bench to Clinic"
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8:30 pm - 8:45 pm |
Discussion
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8:45 pm - 9:20 pm |
Hugh Willison (University of Glasgow, United Kingdom)
"Glycosphingolipids in Neuronal Homeostasis and Disease"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Measuring and Manipulating Sphingolipids and Glycosphingolipids: Challenges and Solutions
Discussion Leaders: Yusuf Hannun (Stony Brook University, USA) and Maria Fuller (SA Pathology, Australia)
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9:00 am - 9:10 am |
Introduction by Discussion Leader
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9:10 am - 9:30 am |
Roger Sandhoff (German Cancer Research Center, Germany)
"Chromatography & Mass Spectrometry: Why There Is No All-in-One Solution For Sphingolipidomics"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:00 am |
Liana Silva (University of Lisbon, Portugal)
"Fluorescence Methods to Investigate the Biophysical Properties of Sphingolipids"
|
10:00 am - 10:10 am |
Discussion
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10:10 am - 10:40 am |
Coffee Break
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10:40 am - 10:55 am |
Noemi Jimenez-Rojo (University of Geneva, Switzerland)
"Optical Control of Membrane Fluidity Modulates Protein Secretion"
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10:55 am - 11:05 am |
Discussion
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11:05 am - 11:25 am |
Joost Holthuis (University of Osnabrueck, Germany)
"Ca2+-Activated Sphingomyelin Scrambling and Turnover Mediate ESCRT-Independent Lysosomal Repair"
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11:25 am - 11:35 am |
Discussion
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11:35 am - 11:55 am |
Giovanni D'Angelo (École Polytechnique Fédérale de Lausanne, Switzerland)
"Sphingolipids Control Dermal Fibroblast Heterogeneity"
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11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:20 pm |
Wing-Kee Lee (Bielefeld University, Germany)
"Interrogating Ceramide Synthase Contribution to Transmembrane Protein Functionalization in Renal Cancer"
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12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Cynthia Tifft (National Human Genome Research Institute, NIH, USA) and Doris Höglinger (Heidelberg University Biochemistry Center, Germany)
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
Ceramide Biology and Pathophysiology
Discussion Leaders: Tony Futerman (Weizmann Institute of Science, Israel) and Gerhild Van Echten-Deckert (Universität Bonn, Germany)
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6:00 pm - 6:20 pm |
Teresa Dunn (Uniformed Services Univ of the Health Sciences, USA)
"Pathogenic Mutations in Serine Palmitoyltransferase Cause Multiple Neurodegenerative Diseases"
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6:20 pm - 6:30 pm |
Discussion
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6:30 pm - 6:50 pm |
Iris Zelnik (Weizmann Institute of Science, Israel)
"Structure-Function Analysis of Ceramide Synthases"
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6:50 pm - 7:00 pm |
Discussion
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7:00 pm - 7:20 pm |
Alicia Alonso (University of the Basque Country , Spain)
"The Physical Properties of Ceramides and Their Pathophysiological Correlations"
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7:20 pm - 7:30 pm |
Discussion
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7:30 pm - 7:50 pm |
Myles Cabot (Brody School of Medicine, East Carolina University, USA)
"Avenues for Boosting Therapeutic Potential of the 'Ceramide Effect'"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Sphingosine and Sphingosine-1-Phosphate Biology and Pathophysiology
Discussion Leaders: Sarah Spiegel (Virginia Commonwealth University, USA) and Timothy Cox (University of Cambridge, United Kingdom)
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9:00 am - 9:20 am |
Julie Saba (University of California, San Francisco, USA)
"The Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency"
|
9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Wiebke Herzog (Friedrich-Alexander-Univ Erlangen-Nuremberg, Germany)
"Interaction of Wnt and S1P Signaling Regulates Brain Angiogenesis"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:50 am |
Doris Höglinger (Heidelberg University Biochemistry Center, Germany)
"Sphingosine Exits Lysosomes via Known Cholesterol Transporters NPC1 and LIMP2"
|
10:50 am - 11:00 am |
Discussion
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11:00 am - 11:20 am |
Markus Graeler (Jena University Hospital, Germany)
"Sphingosine 1-phosphate Signaling in Systemic Inflammation"
|
11:20 am - 11:30 am |
Discussion
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11:30 am - 11:50 am |
Eric Camerer (Paris Cardiovascular Research Center, France)
"S1P Receptor-1 Signaling at the Blood-Brain Barrier"
|
11:50 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Shah Alam (Kekulé-Institute Life & Medical Sciences Institute, Germany)
"S1P-Lyase Deficiency in the Brain Increases Glucose Breakdown Evoking a P2Y1 Receptor-Dependent Astrogliosis"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Youn-Jeong Choi (UCSF, USA)
"The Effects of Gut-Specific S1P Lyase Deficiency on the Intestinal Transcriptome and Microbiome"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Glycosphingolipids: Biosynthesis, Function and Disease
Discussion Leaders: Doris Höglinger (Heidelberg University Biochemistry Center, Germany) and Roger Sandhoff (German Cancer Research Center, Germany)
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6:00 pm - 6:20 pm |
Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine, Italy)
"ER-Golgi Contact Sites"
|
6:20 pm - 6:30 pm |
Discussion
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6:30 pm - 6:50 pm |
Janet Deane (University of Cambridge, United Kingdom)
"Identifying New Players in Krabbe Disease: How Galactosphingolipids Alter Membrane Protein Abundance"
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6:50 pm - 7:00 pm |
Discussion
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7:00 pm - 7:20 pm |
Cynthia Tifft (National Human Genome Research Institute, NIH, USA)
"Gene Therapy for GM1 Gangliosidosis: A Ten-Year Odyssey"
|
7:20 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:40 pm |
Robert Engel (German Cancer Research Center (DKFZ), Germany)
"Glycosphingolipid-Protein Interactions and Renoprotective Mechanisms of Globo-Series Glycosphingolipid Depletion"
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7:40 pm - 7:45 pm |
Discussion
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7:45 pm - 7:55 pm |
Julia Beimdiek (Hannover Medical School - MHH, Germany)
"Generation and Examination of Glycosphingolipid-Depleted Human iPSCs and Their Derivatives"
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7:55 pm - 8:00 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Sphingolipids and Glycosphingolipids as Modulators of Membrane Function
Discussion Leaders: Janet Deane (University of Cambridge, United Kingdom) and Hugh Willison (University of Glasgow, United Kingdom)
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9:00 am - 9:20 am |
Mary Kraft (University of Illinois at Urbana-Champaign, USA)
"Imaging the Cholesterol and Sphingolipid Abundance at the Site of Influenza Virus Assembly"
|
9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Sandro Sonnino (University of Milan, Italy)
"The Different Approaches to Study the Role of Membrane Gangliosides in Modulating Cell Signaling"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Michela Deleidi (German Ctr for Neurodegenerative, Germany)
"Glucocerebrosidase and Brain Disease: Novel Functions Beyond the Lysosome"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:20 am |
Mark Kester (University of Virginia, USA)
"Biophysical Lessons Learned from the Ceramide Nanoliposome Clinical Trial"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:45 am |
Maria Fazzari (University of Milano, Italy)
"GM1 Oligosaccharide Membrane Signalling: The Switch to Turn on a Neuroprotective Program Acting via Mitochondria Modulation"
|
11:45 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Giulia Lunghi (University of Milano, Italy)
"Role of ß-glucocerebrosidase Deficiency in the Onset of Neuronal Degeneration: New Findings on the Involvement of a Lysosome-Plasma Membrane Axis"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Tsaffrir Zor (Tel-Aviv University, Israel)
"Short Fatty Acid Chain Sulfatides are Endogenous Ligands for TLR4/MD-2"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Sphingolipids and Glycosphingolipids in Cell Growth and Differentiation
Discussion Leaders: James Shayman (University of Michigan, USA) and Julie Saba (University of California, San Francisco, USA)
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6:00 pm - 6:20 pm |
Alessandra D'Azzo (St. Jude Children's Research Hospital, USA)
"Organellar Membrane Contact Sites in the Synaptogenesis and Synaptopathy of GM1-Gangliosidosis"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Erhard Bieberich (University of Kentucky, USA)
"Ceramide-Enriched Exosomes in Alzheimer's Disease: Role in Pathophysiology and Novel Pharmacological Target"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Richard Kolesnick (Memorial Sloan-Kettering Cancer Center, USA)
"Endothelial Cell Apoptosis Determines Intestinal Stem Cell Fate"
|
7:20 pm - 7:30 pm |
Discussion
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7:30 pm - 7:50 pm |
Sara Grassi (Università degli Studi di Milano, Italy)
"Sphingolipids Orchestrating the Cross-Talk Between Different Cell Populations in the Repair of Damaged Myelin"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Late-Breaking Topics
Discussion Leaders: Walter Holleran (University of California, San Franciso, USA) and Mylene Huebecker (Federal Institute for Drugs and Medical Devices, Germany)
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9:00 am - 9:20 am |
Yohann Boutte (French National Centre for Scientific Research, France)
"A Novel Mechanism in Sphingolipid-Mediated Phosphoinositide Homeostasis at Trans-Golgi Network"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Fikadu Tafesse (Oregon Health & Science University, USA)
"The Multifaceted Roles of Sphingolipids in Microbial Infection"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:50 am |
Stefanka Spassieva (University of Kentucky, USA)
"Oral L-serine Prevents Taxane-Induced Neuropathic Behaviors in Mice"
|
10:50 am - 11:00 am |
Discussion
|
11:00 am - 11:20 am |
Hans Aerts (Leiden University, The Netherlands)
"Glucosylceramide As Precursor of Glucosylsphingosine and Glucolites"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Leobarda Robles-Martinez (University of Kentucky, USA)
"Hepatic Ceramide Accumulation During Fatty Liver Disease Requires Active Neutral Sphingomyelinase-2 and Drives Insulin Resistance"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Tolulope Sokoya (University of Osnabrueck, Germany)
"Pathogenic Variants of SMS2 Disrupt Lipid Landscapes in the Secretory Pathway"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Sphingolipids and Glycosphingolipids in Non-Mammalian Systems
Discussion Leaders: Teresa Dunn (Uniformed Services Univ of the Health Sciences, USA) and Maurizio Del Poeta (Stony Brook University, USA)
|
6:00 pm - 6:20 pm |
Manuel Muñiz (University of Sevilla, Spain)
"Ceramide Chain Length-Dependent Protein Sorting Into Selective Endoplasmic Reticulum Exit Sites "
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:40 pm |
Binks Wattenberg (Virginia Commonwealth University, USA)
"The ORMDL Regulatory Subunit of Serine Palmitoyl Transferase Senses Cellular Ceramide Levels Through Two Distinct Mechansims"
|
6:40 pm - 6:45 pm |
Discussion
|
6:45 pm - 7:05 pm |
Eric Brown (The Broad Institute of MIT and Harvard, USA)
"Bacterial Sphingolipids Mediate Host-Microbiome Interactions in the Intestine"
|
7:05 pm - 7:15 pm |
Discussion
|
7:15 pm - 7:35 pm |
Dominic Campopiano (University of Edinburgh, United Kingdom)
"Discovery of Cryptic Bacterial Sphingolipids Reveals a Convergent Evolutionary Biosynthetic Pathway"
|
7:35 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Sebastien Mongrand (CNRS, France)
"Multiple Biophysical Approaches To Study the Role of Plant Sphingolipids GIPC in Plasma Membrane Organization"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|