Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Sphingolipids and Glycosphingolipids in Cell Biology and Disease
Session in memory of Lina Obeid.
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:30 pm
"Sphingosine-1-Phosphate: From Bench to Clinic"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Glycosphingolipids in Neuronal Homeostasis and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Measuring and Manipulating Sphingolipids and Glycosphingolipids: Challenges and Solutions
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Chromatography & Mass Spectrometry: Why There Is No All-in-One Solution For Sphingolipidomics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Fluorescence Methods to Investigate the Biophysical Properties of Sphingolipids"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Optical Control of Membrane Fluidity Modulates Protein Secretion"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Ca2+-Activated Sphingomyelin Scrambling and Turnover Mediate ESCRT-Independent Lysosomal Repair"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Sphingolipids Control Dermal Fibroblast Heterogeneity"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Interrogating Ceramide Synthase Contribution to Functionalization of Membrane Proteins ABCB1 and Megalin in the Kidney"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ceramide Biology and Pathophysiology
6:00 pm - 6:20 pm
"Pathogenic Mutations in Serine Palmitoyltransferase Cause Multiple Neurodegenerative Diseases"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Structure-Function Analysis of Ceramide Synthases"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The Physical Properties of Ceramides and Their Pathophysiological Correlations"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Avenues for Boosting Therapeutic Potential of the 'Ceramide Effect'"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sphingosine and Sphingosine-1-Phosphate Biology and Pathophysiology
9:00 am - 9:20 am
"The Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Interaction of Wnt and S1P Signaling Regulates Brain Angiogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Sphingosine Exits Lysosomes via Known Cholesterol Transporters NPC1 and LIMP2"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Sphingosine 1-phosphate Signaling in Systemic Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"S1P Receptor-1 Signaling at the Blood-Brain Barrier"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"S1P-Lyase Deficiency in the Brain Increases Glucose Breakdown Evoking a P2Y1 Receptor-Dependent Astrogliosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Effects of Gut-Specific S1P Lyase Deficiency on the Intestinal Transcriptome and Microbiome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycosphingolipids: Biosynthesis, Function and Disease
6:00 pm - 6:20 pm
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Identifying New Players in Krabbe Disease: How Galactosphingolipids Alter Membrane Protein Abundance"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Gene Therapy for GM1 Gangliosidosis: A Ten-Year Odyssey"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Glycosphingolipid-Protein Interactions and Renoprotective Mechanisms of Globo-Series Glycosphingolipid Depletion"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Generation and Examination of Glycosphingolipid-Depleted Human iPSCs and Their Derivatives"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sphingolipids and Glycosphingolipids as Modulators of Membrane Function
9:00 am - 9:20 am
"Imaging the Cholesterol and Sphingolipid Abundance at the Site of Influenza Virus Assembly"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Different Approaches to Study the Role of Membrane Gangliosides in Modulating Cell Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Biophysical Lessons Learned from the Ceramide Nanoliposome Clinical Trial"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
"GM1 Oligosaccharide Membrane Signalling: The Switch to Turn on a Neuroprotective Program Acting via Mitochondria Modulation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Role of ß-glucocerebrosidase Deficiency in the Onset of Neuronal Degeneration: New Findings on the Involvement of a Lysosome-Plasma Membrane Axis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Short Fatty Acid Chain Sulfatides are Endogenous Ligands for TLR4/MD-2"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sphingolipids and Glycosphingolipids in Cell Growth and Differentiation
6:00 pm - 6:20 pm
"Organellar Membrane Contact Sites in the Synaptogenesis and Synaptopathy of GM1-Gangliosidosis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Ceramide-Enriched Exosomes in Alzheimer's Disease: Role in Pathophysiology and Novel Pharmacological Target"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Endothelial Cell Apoptosis Determines Intestinal Stem Cell Fate"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Sphingolipids Orchestrating the Cross-Talk Between Different Cell Populations in the Repair of Damaged Myelin"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:20 am
"A Novel Mechanism in Sphingolipid-Mediated Phosphoinositide Homeostasis at Trans-Golgi Network"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"The Multifaceted Roles of Sphingolipids in Microbial Infection"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Glucocerebrosidase and Brain Disease: Novel Functions Beyond the Lysosome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Oral L-serine Prevents Taxane-Induced Neuropathic Behaviors in Mice"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Glucosylceramide as Precursor of Glucosylsphingosine and Glucolites"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Hepatic Ceramide Accumulation During Fatty Liver Disease Requires Active Neutral Sphingomyelinase-2 and Drives Insulin Resistance"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Pathogenic Variants of SMS2 Disrupt Lipid Landscapes in the Secretory Pathway"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sphingolipids and Glycosphingolipids in Non-Mammalian Systems
6:00 pm - 6:20 pm
"Ceramide Chain Length-Dependent Protein Sorting Into Selective Endoplasmic Reticulum Exit Sites "
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Bacterial Sphingolipids Mediate Host-Microbiome Interactions in the Intestine"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Discovery of Cryptic Bacterial Sphingolipids Reveals a Convergent Evolutionary Biosynthetic Pathway"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Multiple Biophysical Approaches To Study the Role of Plant Sphingolipids GIPC in Plasma Membrane Organization"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure