Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Novel Structural and Biologic Insights in Hemostasis
Discussion Leader: Timothy Stalker (Thomas Jefferson University, United States)
7:40 pm - 8:05 pm
Sol Schulman (Beth Israel Deaconess Medical Center and Harvard Medical School, United States)
"Functional Genetics of Tissue Factor in Bleeding and Thrombotic Risk"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Keith Neeves (University of Colorado Denver, United States)
"Escaping Flatland: High Content Screening of Thrombus Formation on 3D Structures"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ze Zheng (Medical College of Wisconsin; Versiti Blood Research Institute , United States)
"Reciprocal Regulation Between Lipoproteins and Blood Clotting"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular and Physiologic Models of Hemostasis
Discussion Leader: Valerie Tutwiler (Rutgers University, United States)
9:00 am - 9:25 am
Qin (Maggie) Qi (Massachusetts Institute of Technology, United States)
"Understanding Microvascular Adhesion Through in Silico-In Vitro Models"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jordan Shavit (University of Michigan, United States)
"Trawling for Genetic Modifiers of Hemostasis and Thrombosis Through Genome Editing in Zebrafish"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:10 am
Lola Eniola-Adefeso (University of Michigan, United States)
"Next-Gen Polymeric Particles for Control of Platelet-Neutrophil/Endothelium Dynamics in Thromboinflammatory Diseases"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
Ton Lisman (University Medical Center Groningen, The Netherlands)
"Production of Hemostatic Proteins During Normothermic Machine Perfusion of Human Livers for 7 Days"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Donald Lynch (University of Cincinnati, United States)
"Platelets in Valvular Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Miguel Cruz (Baylor College of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Thromboinflammation
Discussion Leader: Ammon Fager (Duke University, United States)
7:30 pm - 7:55 pm
Lalitha Nayak (Case Western Reserve University, United States)
"Neutrophil Inflammasome in Thromboinflammation"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Ishac Nazy (McMaster University, Canada)
"Biochemical and Molecular Characteristic of Anti-PF4 Antibodies and their Clinical Implications in Immune-Mediated Platelet Disorders"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Kandace Gollomp (Children's Hospital of Philadelphia, United States)
"Untangling the NET: Stabilizing Neutrophil Extracellular Traps to Accelerate Bacterial Clearance and Limit Thrombosis in Sepsis"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Interactions in Hemostasis
Discussion Leader: Ejaife Agbani (University of Calgary, Canada)
9:00 am - 9:25 am
Wally Whiteheart (University of Kentucky, United States)
"Endo- and Exocytosis: Why Do They Matter For Platelet Function?"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Vijay Rao (The University of Texas at Tyler Health Science Center, United States)
"Coagulation Protease-Induced Endothelial Extracellular Vesicles: Their Impact on Hemostasis, Inflammation, and Hemophilia Treatment"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Bryce Kerlin (Abigail Wexner Research Institute at Nationwide Children's, United States)
"Prothrombotic Effects of Hypoalbuminemia"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
Shannon Meeks (Emory University and Children's Healthcare of Atlanta, United States)
"Unraveling the Immune Response to Factor VIII"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Jamie O'Sullivan (Royal College of Surgeons in Ireland, Ireland)
"Crosstalk Between Coagulation and Cancer: The Role of Endothelial Von Willebrand Factor"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Endothelial and Coagulation Cross-Talk
Discussion Leader: Erica Sparkenbaugh (UNC Chapel Hill, United States)
7:30 pm - 7:55 pm
Jessica Cardenas (The University of Colorado - Denver, United States)
"HS3ST1 and the Antithrombin-Endothelial Axis During Acute Illness: A Regulator of Coagulation, Inflammation, or Both?"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Anna Randi (Imperial College London, United Kingdom)
"Transcriptional Control of Endothelial Hemostatic Balance"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Prithu Sundd (VERSITI Blood Research Institute, VERSITI Blood Center of Wisconsin and Medical College of Wisconsin, United States)
"Purinergic Regulation of Lung Thrombosis in Sickle Cell Disease"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural and Biochemical Basis of Hemostasis
Discussion Leader: Richard Francis (Columbia University, United States)
9:00 am - 9:25 am
Philip Hogg (Centenary Institute, Australia)
"Interactions of Multiple Covalent States of FVIII"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Alan Mast (Versiti, United States)
"Factor V Interaction with TFPI in Hemostasis, Thrombosis, and Cerebrovascular Development"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Joshua Muia (Oklahoma State University Center for Health Sciences, United States)
"Mechanistic Insights into the Autoregulation of ADAMTS13 Metalloprotease"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
Robert Ariëns (Univ of Leeds, United Kingdom)
"Targeting Fibrin Structure"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Shekhar Kumar (The Children's Hospital of Philadelphia, United States)
"Bioinspired Approaches to Modulate Hemostasis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late Breaking Topics
Discussion Leader: Marvin Nieman (Case Western Reserve University, United States)
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Matrix Contributions to Hemostasis
Discussion Leader: David Bark (Washington University in St. Louis, United States)
9:00 am - 9:25 am
Marie Hollenhorst (Brigham and Women's Hospital, United States)
"Human Platelet Glycoprotein IIb is Glycosylated at the Polymorphic Serine Residue That Defines Human Platelet Antigen 3b"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Matthew Flick (University of North Carolina at Chapel Hill, United States)
"Nonpolymerizable Fibrinogen in Hemostasis and Thrombosis"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Miguel Cruz (Baylor College of Medicine, United States)
"Thromboinflammation: A Closer View to Fibrils"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
Long Zheng (University of Kansas Medical Center, United States)
"ADAMTS13 and TTP"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Hemostatic Complications of the COVID19 Pandemic: Basic and Clinical Insights
Discussion Leader: Jerrold Levy (Duke University Medical Centre, Durham, NC, United States)
7:30 pm - 8:15 pm
Jeffrey Berger (New York University School of Medicine, United States)
"Thromboinflammatory Mechanisms in COVID19"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Matthew Neal (University of Pittsburgh School of Medicine, United States)
"Antithrombotic Strategies for Management of COVID19 Thrombosis"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure