2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Initiating a Career in Blood Research
Timothy Stalker (University of Pennsylvania, USA) and Jamie O'Sullivan (Royal College of Surgeons in Ireland, Ireland)
3:45 pm - 4:20 pm
Alan Mast (BloodCenter of Wisconsin, USA) "Initiating a Career in Blood Research"
4:20 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Building on the Basics: New Discoveries in Thrombosis and Hemostasis
Scott Cooper (University of Wisconsin-La Crosse, USA) and Francis Ayombil (Children's Hospital of Philadelphia Research Institute, USA)
7:30 pm - 7:45 pm
Amy Siebert-McKenzie (Oakland University, USA) "A Missense Mutation in the Loss-of-Function Intolerant Actr2 Gene Suppresses Thrombosis via Regulation of Thrombin Availability and Platelet Function"
7:45 pm - 7:50 pm
7:50 pm - 8:05 pm
Fabienne Birkle (University of Michigan Medical School, USA) "A Flexible Serine Loop in the Ectodomain of Tissue Factor Serves as Potential Allosteric Linker Between the Phospholipid Membrane and the Tissue Factor Exosite"
8:05 pm - 8:10 pm
8:10 pm - 8:25 pm
Matthew Sorrells (Colorado School of Mines, USA) "A Microfluidic Model of Hemostasis Sensitive to Platelet Function and Coagulation"
8:25 pm - 8:30 pm
8:30 pm - 8:45 pm
DaShawn Hickman (Case Western Reserve University, USA) "Design of Biomaterials-Based Technologies for Intravenous Mitigation of Trauma-Associated Hemorrhage and Coagulopathy"
8:45 pm - 8:50 pm
8:50 pm - 9:05 pm
Xu Han (Case Western Reserve University, USA) "Understanding the Activation Mechanism of Protease-Activated Receptor 4 (PAR4) by Hydrogen/Deuterium Exchange Mass Spectrometry"
9:05 pm - 9:10 pm
9:10 pm - 9:25 pm
Tine Wyseure (The Scripps Research Institute, USA) "Defective TAFI Activation and uPA-Mediated Fibrinolysis Contribute to Hemophilic Joint Bleeding"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Platelets and Other Cells in Coagulation / Mentorship Component: Pathways to Success: Navigating a Career in Science
Sidney Whiteheart (University of Kentucky, USA) and Daniëlle Coenen (Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands)
9:00 am - 9:15 am
Noor Shaik (Thomas Jefferson University, USA) "Inhibition of ASK1, a Key Regulator of Platelets, Attenuates Ischemia/Reperfusion Injury Following Stroke"
9:15 am - 9:20 am
9:20 am - 9:35 am
Miguel Neves (St. Michael's Hospital / University of Toronto, Canada) "Development of Novel Anti-Fouling Molecular Probes to Detect New Platelet Ligands and Pathogenic Anti-Platelet Antibodies"
9:35 am - 9:40 am
9:40 am - 9:55 am
Maria Selvadurai (Australian Centre for Blood Diseases, Monash University, Australia) "Targeting the Platelet Internal Membrane Reveals a Novel Approach for Improved Anti-Platelet Therapies"
9:55 am - 10:00 am
10:00 am - 10:15 am
Zachary Hilt (University of Rochester, USA) "Platelet Derived Beta-2 Microglobulin and Transforming Growth Factor Beta Act Antagonistically to Regulate Monocyte Phenotype"
10:15 am - 10:20 am
10:20 am - 11:00 am
Pathways to Success: Navigating a Career in Science
Maria Aleman (Bioverativ, USA)
Gow Arepally (Duke University School of Medicine, USA)
Scott Cooper (University of Wisconsin-La Crosse, USA)
Timothy Stalker (University of Pennsylvania, USA)
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Crosstalk with Coagulation
Alan Mast (BloodCenter of Wisconsin, USA) and James Byrnes (University of North Carolina at Chapel Hill, USA)
1:30 pm - 1:45 pm
Yohei Hisada (University of North Carolina at Chapel Hill, USA) "Neutrophil Extracellular Traps Enhance Venous Thrombus Formation in Mice Containing Human Pancreatic Tumors"
1:45 pm - 1:50 pm
1:50 pm - 2:05 pm
Dafna Groeneveld (Michigan State University, USA) "Intrahepatic Fibrin(ogen) Deposition Drives Liver Regeneration After Partial Hepatectomy in Mice and Humans"
2:05 pm - 2:10 pm
2:10 pm - 2:25 pm
Clive Drakeford (Trinity Collage Dublin, Ireland) "A Novel Role for von Willebrand Factor Promoting Pro-Inflammatory Responses in Macrophages"
2:25 pm - 2:30 pm
2:30 pm - 3:00 pm
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