Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
The Connectivity Between Methodology Development and Total Synthesis
Discussion Leader: Christa Chrovian (Janssen R&D, USA)
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7:40 pm - 7:50 pm |
Opening Remarks
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7:50 pm - 8:30 pm |
Doug Frantz (University of Texas at San Antonio, USA)
"From Synthesis to Therapeutic Application: Making Heterocycles Great Again"
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8:30 pm - 8:40 pm |
Discussion
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8:40 pm - 9:20 pm |
Tehshik Yoon (University of Wisconsin-Madison, USA)
"Photocatalytic Oxidation Reactions"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Improvements to the Synthesis of Heterocyclic Compounds
Discussion Leader: Sarah Wengryniuk (Temple University, USA)
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9:00 am - 9:35 am |
Jennifer Roizen (Duke University, USA)
"Sulfamate Esters Guide Atom-Transfer Processes"
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9:35 am - 9:45 am |
Discussion
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9:45 am - 10:00 am |
Selected from Poster Abstracts: Tomohiro Yasukawa (The University of Tokyo, Japan)
"N-Doped Carbon-Supported Cobalt Nanoparticle Catalysis for Oxidation Reactions Based on Polymer Incarceration Methods"
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10:00 am - 10:10 am |
Discussion
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10:10 am - 10:40 am |
Coffee Break
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10:40 am - 11:10 am |
Chong Han (Genentech, Inc., USA)
"Chemoselective, Stereocontrolled Cu-Catalyzed C-N Couplings Towards a Highly Potent mPI3Ka Inhibitor"
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11:10 am - 11:20 am |
Discussion
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11:20 am - 12:00 pm |
Jeffrey Johnson (University of North Carolina at Chapel Hill, USA)
"Bioactive Natural Products and New Reactions to Prepare Them: The Symbiotic Loop"
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12:00 pm - 12:10 pm |
Discussion
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12:10 pm - 12:30 pm |
Poster Previews
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Unique Applications of Heterocycles to Broad Biology Challenges
Discussion Leader: Daniel Elbaum (QurAlis Corporation, USA)
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7:30 pm - 8:05 pm |
Cynthia Jesudason (Independent Consultant, USA)
"Discovery and Development of PET Tracers for Neuroscience"
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8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:35 pm |
Selected from Poster Abstracts: Ryan Altman (The University of Kansas, USA)
"Tryptophan-Derived Probes for Studying the Kynurenine Pathway"
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8:35 pm - 8:45 pm |
Discussion
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8:45 pm - 9:20 pm |
Matthew Shair (Harvard University, USA)
"Roles of CDK8/19 in Oncology"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Development of Methodology for Improved Heterocyclic Synthesis
Discussion Leader: Jason Herr (Albany Molecular Research, Inc (AMRI), USA)
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9:00 am - 9:30 am |
David Nagib (The Ohio State University, USA)
"C-H and C-O Functionalization via Radical Chaperones"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:10 am |
Brian Laforteza (Janssen Pharmaceuticals, Johnson & Johnson, USA)
"Discovery and Synthesis of Triazolopyridines as Potent and Selective AMPAR γ8-TARP Negative Modulators"
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10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:20 am |
Song Lin (Cornell University, USA)
"An Electrocatalytic Approach to New Reaction Discovery"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 12:00 pm |
Carolyn Anderson (Calvin College, USA)
"Synthesis of Highly Functionalized N-Alkyl 2-Pyridones and Indolizines"
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12:00 pm - 12:10 pm |
Discussion
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12:10 pm - 12:30 pm |
Poster Previews
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
The Use of Novel Approaches to the Synthesis of Biologically Active Compounds
Discussion Leader: Corinna Schindler (University of Michigan, USA)
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7:30 pm - 8:05 pm |
Amelie Dion (Pfizer Inc, USA)
"Exploratory Process Development of a Second Generation Beta-Amyloid Cleaving Enzyme (BACE1) Inhibitor"
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8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:35 pm |
Selected from Poster Abstracts: Kevin Frankowski (University of North Carolina at Chapel Hill, USA)
"Discovery and Optimization of Novel Dopamine Receptor Modulators for the Treatment of CNS Disorders"
|
8:35 pm - 8:40 pm |
Discussion
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8:40 pm - 9:20 pm |
Jeff Kuethe (Merck & Co., Inc., USA)
"Synthesis of a Highly Functionalized Octahydro-Isoindole-Based NK1 Receptor Antagonist"
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9:20 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Heterocycles and Their Use as Biological Probes
Discussion Leader: George Sheppard (AbbVie, Inc., USA)
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9:00 am - 9:30 am |
Jimmy Wu (Dartmouth College, USA)
"New Reactions of Indole for Enabling Synthesis and Biology"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:10 am |
Alison Frontier (University of Rochester, USA)
"Reaction Cascades for Heterocycle Synthesis"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:20 am |
Thomas Hoye (University of Minnesota, USA)
"Natural Product Synthesis"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 12:05 pm |
Sarah Reisman (California Institute of Technology, USA)
"Total Synthesis of Complex Natural Products"
|
12:05 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
The Use of Heterocycles in Catalysis
Discussion Leader: Jennifer Howell (Eli Lilly and Company, USA)
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7:30 pm - 8:05 pm |
Eric Voight (AbbVie, USA)
"Heterocycle Synthesis for the Treatment of Pain, Cystic Fibrosis and Hepatitis C"
|
8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:35 pm |
Selected from Poster Abstracts: Indrajeet Sharma (University of Oklahoma, USA)
"Leveraging Metal Carbenes for Assembling Complexity"
|
8:35 pm - 8:40 pm |
Discussion
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8:40 pm - 9:20 pm |
Corey Stephenson (University of Michigan, USA)
"Redox Catalysis Strategies for Complex Molecules"
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9:20 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
New Strategies for the Synthesis of Heterocycles
Discussion Leader: Paul Ornstein (Medical College of Wisconsin, USA)
|
9:00 am - 9:35 am |
Ryan Moslin (Bristol-Myers Squibb, USA)
"TYK2"
|
9:35 am - 9:45 am |
Discussion
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9:45 am - 10:20 am |
Emily Balskus (Harvard University, USA)
"Deciphering the Gut Microbiota with Chemistry"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:35 am |
Scott Sutton (Pfizer, USA)
"Discovery and Synthesis of PF-6821497, a Potent EZH2 Inhibitor"
|
11:35 am - 11:45 am |
Discussion
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11:45 am - 12:20 pm |
Laura Anderson (University of Illinois at Chicago, USA)
"New Synthetic Opportunities with Alkenyl Nitrones and Hydroxylamines"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Keynote Session: Nature Inspired Synthesis of Heterocyclic Natural Products
Discussion Leader: Justin Lopchuk (Moffitt Cancer Center, USA)
|
7:30 pm - 8:15 pm |
Phil Baran (The Scripps Research Institute, USA)
"Translational Chemistry"
|
8:15 pm - 8:25 pm |
Discussion
|
8:25 pm - 9:10 pm |
Erik Sorensen (Princeton University, USA)
"Inspired by Molecular Structure and the Challenge of Doing Chemistry on Strong C-H Bonds"
|
9:10 pm - 9:20 pm |
Discussion
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9:20 pm - 9:30 pm |
Closing Remarks
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
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