Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Methodological Breakthroughs with Heterocyclic Compounds
Discussion Leader: Carolyn Anderson (Calvin College, USA)
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7:40 pm - 7:45 pm |
Opening Remarks
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7:45 pm - 8:15 pm |
Keary Engle (The Scripps Research Institute, USA)
"Catalytic Alkene Functionalization for Heterocycle Synthesis and Derivatization"
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8:15 pm - 8:25 pm |
Discussion
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8:25 pm - 8:40 pm |
Selected from Poster Abstracts: Mark McLaughlin (Manchester Metropolitan University, United Kingdom)
"Calcium Catalysed Generation and Utilization of Reactive Intermediates"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Yoshiaki Nakao (Kyoto University, Japan)
"C-H Functionalization of Heterocycles by Cooperative Catalysis"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Heterocycles in Complex Molecule Synthesis
Discussion Leader: Scott Pollack (Merck & Co., Inc, USA)
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9:00 am - 9:35 am |
Joshua Pierce (North Carolina State University, USA)
"Synthesis of Bioactive Heterocyclic Natural Products"
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9:35 am - 9:45 am |
Discussion
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9:45 am - 10:20 am |
Christopher Beaudry (Oregon State University, USA)
"Regiospecific Syntheses and Reactions of Aromatic Molecules"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:15 am |
Selected from Poster Abstracts: Pallavi Sharma (La Trobe University, Australia)
"3D Hetero-Spirocycles: Synthesis and Application"
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11:15 am - 11:25 am |
Discussion
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11:25 am - 12:00 pm |
Jieping Zhu (École Polytechnique Fédérale de Lausanne, Switzerland)
"Total Synthesis of Polycyclic Indole Alkaloids Enabled by Skeletal Reorganization"
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12:00 pm - 12:10 pm |
Discussion
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12:10 pm - 12:30 pm |
Poster Previews
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Catharine Larsen (University of California, Riverside, USA) and Carolyn Anderson (Calvin College, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Catalysis in Heterocyclic Contexts
Discussion Leader: Maryll Geherty (Celgene, USA)
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7:30 pm - 8:00 pm |
Robert Phipps (University of Cambridge, United Kingdom)
"Harnessing Non-Covalent Interactions to Address Selectivity Challenges in Catalysis"
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8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Tianning Diao (New York University, USA)
"Stereoselective Alkene Functionalization via Radical Pathways"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Alexander Radosevich (Massachusetts Institute of Technology, USA)
"Organophosphorus-Catalyzed Methods Based on P(III)/P(V) Redox Cycling"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 12:30 pm |
Free Time
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 5:00 pm |
Heterocycles as a Platform for Advances in Synthesis
Discussion Leader: Catharine Larsen (University of California, Riverside, USA)
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1:30 pm - 2:00 pm |
Uttam Tambar (University of Texas Southwestern Medical Center, USA)
"Stereoselective Functionalization of Unsaturated Hydrocarbons"
|
2:00 pm - 2:10 pm |
Discussion
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2:10 pm - 2:35 pm |
Volker Derdau (Sanofi, Germany)
"Isotope and Medicinal Chemistry Late Stage Functionalizations in Drug Discovery"
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2:35 pm - 2:45 pm |
Discussion
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2:45 pm - 3:15 pm |
Coffee Break
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3:15 pm - 3:30 pm |
Selected from Poster Abstracts: Zhang Wang (University at Albany, SUNY, USA)
"Biomimetic Synthesis of Hitorins A and B"
|
3:30 pm - 3:40 pm |
Discussion
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3:40 pm - 4:05 pm |
Kyle Quasdorf (Amgen, USA)
"Mechanistic Studies on the Unexpected Racemization of Cyclopropyl Isoxazolines"
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4:05 pm - 4:15 pm |
Discussion
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4:15 pm - 4:50 pm |
Daniel Seidel (University of Florida, USA)
"New Strategies for the C-H Functionalization of Amines"
|
4:50 pm - 5:00 pm |
Discussion
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5:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Inventions in Heterocycle-Based Functionalization
Discussion Leader: Adam Levinson (Eli Lilly and Company, USA)
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7:30 pm - 8:05 pm |
Daniel Weix (University of Wisconsin-Madison, USA)
"Engaging Challenging Substrates in Cross-Electrophile Coupling"
|
8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:30 pm |
Selected from Poster Abstracts: Jeffrey Gustafson (San Diego State University, USA)
"Atropisomerism as a Tool in Drug Discovery and an Inspiration for New Chemistry"
|
8:30 pm - 8:40 pm |
Discussion
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8:40 pm - 9:20 pm |
Maria Christina White (University of Illinois at Urbana-Champaign, USA)
"Asymmetric C-H Oxidations"
|
9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Route Development and Optimization to Bioactive Heterocycles
Discussion Leader: James Devery (Loyola University Chicago, USA)
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9:00 am - 9:30 am |
Yi-Yin Ku (AbbVie, USA)
"Synthetic Route Development Utilizing a C-N Cross-Coupling Approach for a Drug Candidate"
|
9:30 am - 9:40 am |
Discussion
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9:40 am - 10:10 am |
Nick Magnus (Eli Lilly and Company, USA)
"Diastereoselective Pictet-Spengler Based Synthesis of a D1 Potentiator"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:20 am |
Angela Puchlopek-Dermenci (Pfizer, Inc., USA)
"Commercial Route Development of Daurismo (Glasdegib), a SMO Inhibitor"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 12:00 pm |
Allen Hong (Genentech, USA)
"Process Development Enables the Synthesis of a Complex Macrocyclic Peptide Antibiotic"
|
12:00 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
New Methods Toward Heterocyclic Compounds
Discussion Leader: Terry Lebold (Janssen Research & Development, USA)
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7:30 pm - 8:00 pm |
Joseph Topczewski (University of Minnesota, USA)
"Allylic Azides: Harnessing the Winstein Rearrangement Through DKR"
|
8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Simon Blakey (Emory University, USA)
"Beyond Cp*: Mechanism Driven Development of a New Rhodium Complex for Enantioselective C-H Functionalization"
|
8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Daniel Werz (Technische Universitat Braunschweig, Germany)
"Donor-Acceptor Cyclopropanes as Masked 1,3-Dipoles for the Synthesis of Heterocyclic Compounds"
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9:20 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
The Interplay of Heterocyclic Compounds and Biological Inquiries
Discussion Leader: Susan Stevenson (Carthage College, USA)
|
9:00 am - 9:30 am |
Alison Narayan (University of Michigan, USA)
"Biocatalysis and Complex Molecule Synthesis"
|
9:30 am - 9:40 am |
Discussion
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9:40 am - 10:05 am |
Sudhir Hande (AstraZeneca Pharmaceuticals LP, USA)
"Discovery and Synthesis of AZD4573, a Potent and Selective CDK9 Inhibitor"
|
10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
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10:45 am - 11:10 am |
Beth Knapp-Reed (GlaxoSmithKline, USA)
"Rapid Discovery of Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:45 am |
Thomas Selby (FMC Agricultural Solutions, USA)
"Discovery of Tetflupyrolimet: A New Mode-of-Action Herbicide Interfering with De Novo Pyrimidine Biosynthesis"
|
11:45 am - 11:55 am |
Discussion
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11:55 am - 12:20 pm |
Nidhi Jain (Indian Institute of Technology Delhi, India)
"Synthetic Transformations via C-H Bond Functionalization"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Prospects in Heterocyclic Chemistry: Synthesis and Related Studies
Discussion Leader: Dionicio Martinez (Drexel University, USA)
|
7:30 pm - 8:10 pm |
John Wood (Baylor University, USA)
"Recent Efforts in the Synthesis of Complex Natural Products"
|
8:10 pm - 8:20 pm |
Discussion
|
8:20 pm - 9:05 pm |
Amos Smith (University of Pennsylvania, USA)
"Synthetic, Bioorganic and Medicinal Chemistry in the Smith Group"
|
9:05 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:30 pm |
Closing Remarks
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|