1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Technology and Platform Development
Robin Krystufek (Institute of Organic Chemistry and Biochemistry AS CR, Czech Republic)
3:45 pm - 4:20 pm
Petra Dittrich (ETH Zurich, Switzerland) "High-Density Droplet Arrays for High Throughput Analysis"
4:20 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Advances in Chemistry and High-Throughput Synthesis + Career Discussion Panel
John Burdick (UCI - Paegel Laboratory, United States)
7:30 pm - 7:45 pm
Xiao Qian Ng (National University of Singapore; Institute of Sustainability for Chemicals, Energy and Environment , Singapore) "Synthesis of Aliphatic Amines Using Borrowing Hydrogen and its Application to Large-Scale Drug Synthesis"
7:45 pm - 7:50 pm
7:50 pm - 8:05 pm
Cassandra Kennedy (The Francis Crick Institute, United Kingdom) "High Throughput Chemistry for Direct to Biology screening against Bacterial E3 Ligases"
8:05 pm - 8:10 pm
8:10 pm - 8:25 pm
Julian Götz (ETH Zürich, Switzerland) "Miniaturized, Predictable, On-Demand Synthesis of Vast Libraries of Drug-Like Molecules"
8:25 pm - 8:30 pm
8:30 pm - 9:30 pm
Career Panel Discussion
Jennifer Heemstra (Washington University in St. Louis, United States)
Nessa Carson (AstraZeneca, United Kingdom)
Jordan Reddel (Dow Chemical, United States)
Mark Fitzgerald (Nested Therapeutics, United States)
7:30 am - 8:30 am
9:00 am - 11:00 am
Hot Targets and Novel Discovery Approaches
Tong Lan (University of Chicago, United States)
9:00 am - 9:15 am
Huda Barhoosh (University of California Irvine, United States) "Activity-Based DEL Screening: Expanding the Druggable Proteome Through Selective Modulation of Translation"
9:15 am - 9:20 am
9:20 am - 9:35 am
Bhaskar Chatterjee (University of Michigan, United States) "FICD Inhibitors: Discovery, Development and Validation"
9:35 am - 9:40 am
9:40 am - 9:55 am
Katherine McPhie (The Francis Crick Institute, United Kingdom) "Chemical Biology Approaches to Explore the Ligandability of TRIM E3 Ligases"
9:55 am - 10:00 am
10:00 am - 10:15 am
Leslie Spitalny (University of California, Irvine , United States) "A General Fluorescence-Based Assay Measuring Compound Accumulation in Cells"
10:15 am - 10:20 am
10:20 am - 10:35 am
Amanda Nguyen (University of California, Irvine, United States) "Activity-Based Aptamer Screening"
10:35 am - 10:40 am
10:40 am - 10:55 am
Tessa Epstein (University of Michigan, United States) "Integrated High Throughput Synthesis and Screening Enable Discovery of Dynamic Protein Modulators"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Omics's and AI - Cheminformatics, Machine Learning, and High-throughput Analysis
Giulia Murbach-Oliveira (Purdue University, United States)
1:30 pm - 1:45 pm
Samuel Thompson (Stanford, United States) "Developing Design Rules and Screening Tools for Protein Catalysts in Non-aqueous Environments"
1:45 pm - 1:50 pm
1:50 pm - 2:05 pm
Jarrett Pelton (University of North Carolina, United States) "Cheminformatics-Guided Cell Free Biosynthetic Exploration of Peptide Natural Products"
2:05 pm - 2:10 pm
2:10 pm - 2:25 pm
Euan Richards (ETH Zurich, Switzerland) "Enabling an On-Demand Drug Library with High Throughput Synthesis and Cheminformatics."
2:25 pm - 2:30 pm
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)