Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cellular Senescence and Aging: The Path to Translation
Discussion Leader: Robert Baxter (University of Sydney, Australia)
7:40 pm - 8:25 pm
Phyllis Dennery (Brown University, United States)
"The Many Faces and Impacts of Cellular Senescence"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
James Kirkland (Mayo Clinic, United States)
"Cellular Senescence and Senolytics: The Path to Translation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early Life Origins of Health and Disease
Discussion Leader: Stephen Matthews (University of Toronto, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
David Hill (Lawson Health Research Institute, Western University, London, Ontario, Canada)
"Plasticity in the Endocrine Pancreas as a Response to Metabolic Demand"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Rebecca Simmons (University of Pennsylvania, United States)
"The Ying and the Yang of ß-cell Programming"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Miguel Constancia (University of Cambridge, United Kingdom)
"Inter-organ Communication by IGFs: Gatekeepers for Metabolic Health"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Malgorzata Borowiak (Adam Mickiewicz University, Poland)
"Beta Cell Dedifferentiation and Diabetes"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Elisabeth Barton (University of Florida, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Homeostasis and Regeneration: Stem Cells and Cell Plasticity
Discussion Leader: Terri Wood (New Jersey Medical School, Rutgers University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Cunming Duan (University of Michigan, United States)
"Regulation of Epithelial Cell Plasticity by IGF and Calcium Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Jason Mills (Baylor College of Medicine, United States)
"Paligenosis: An mTORC1-Dependent Plasticity Program Cells Use to Change Identity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Friedrich Metzger (Versameb Ltd., Switzerland)
"IGF-I mRNA for Therapy: Regeneration of Muscle Tissue and Function in Stress Urinary Incontinence"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of IGF and Insulin in Nutrient Sensing Related to Lifespan and Disease
Discussion Leader: Jeff Holly (University of Bristol, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Matthew Piper (Monash University, Australia)
"The Nutritional Requirements for Sustaining Life in Drosophila melanogaster"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Marc Tatar (Brown University, United States)
"The Kinase Insert Domain of Drosophila dInr Regulates Aging Through Control of Methionine Metabolism"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Ruben Pio (Cima-University of Navarra, Spain)
"Caloric Restriction and the IGF-I/IGF-1R Axis in Cancer Immunotherapy"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Shin-Ichiro Takahashi (University of Tokyo, Japan)
"Next Generation Nutritional and Feeding Science with Artificial Intelligence Techniques: Controlling Insulin-like Activity by Amino Acid Signaling"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin System in Development and Aging
Discussion Leader: Briony Forbes (Flinders Medical Centre, Flinders University, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Derek Huffman (Albert Einstein College of Medicine, United States)
"Intranasal Targeting with a Potent IGF-1 Analogue to Treat Alzheimer's Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Richard Cubbon (University of Leeds, United Kingdom)
"IGF-1 Signalling, the Vascular Endothelium and Atherosclerosis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Myriam Hemberger (University of Calgary, Canada)
"The Key Role of the Placenta in Mitigating Congenital Defects and Ensuring Offspring Health"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure and Activation Mechanisms of Insulin, IGF and Hybrid Receptors: Recent Advances from Cryo-EM
Discussion Leader: Pierre De Meyts (de Duve Institute, Belgium)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Xiaochen Bai (UT Southwestern Medical Center, United States)
"Activation of the Insulin Receptor via Two Distinct Types of Sites"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Gerd Schluckebier (Novo Nordisk, Denmark)
"Structural Investigations of Full-length Insulin Receptor Dynamics and Signaling"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Ünal Coskun (Center of Membrane Biochemistry and Lipid Research Dresden, Germany)
"Cryo-EM Structure of the Complete and Ligand-saturated Insulin Receptor Ectodomain"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Nicholas Kirk (Walter & Eliza Hall Institute of Medical Research, Australia)
"How Ligands Bind to Insulin, IGF1 and Hybrid Receptors."
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The IGF and Insulin Axis and Cancer
Discussion Leader: Derek Leroith (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Rosemary O'Connor (University College Cork, Ireland)
"Control of IGF-1 Receptor Location in Cancer Cells: a Key to Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Claire Perks (University of Bristol, United Kingdom)
"A role for the IGF axis in Amyloid Precursor Protein Processing in Cancer: Lessons Learnt from Alzheimer’s Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Emily Gallagher (Icahn School of Medicine at Mount Sinai, United States)
"Insulin Receptor Isoforms and Signaling in Cancer"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Targeting the IGF and Insulin Axis in the Clinic
Discussion Leader: Shoshana Yakar (New York University College of Dentistry, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Douglas Yee (Masonic Cancer Center, University of Minnesota, United States)
"What Happened to Targeting IGF-1R in Cancer?"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Joseph Ludwig (MD Anderson Cancer Center, United States)
"Cotargeting the IGF-1/PI3K/mTOR Pathway in Ewing Sarcoma: Is the Story Over or Has it Just Begun?"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Guido Kroemer (University of Paris Cité, France)
"Inhibition of IGF1 Receptor Signaling Improves Cardiac and Immune Functions"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Terry Smith (University of Michigan, United States)
"IGF-1 Receptor; Mischief Maker?"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Methodologies to Advance IGF and Insulin Research
Discussion Leaders: David Clemmons (UNC School of Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
Klaus Kaestner (University of Pennsylvania, United States)
"Growth Effects of IGF-1 in the Gut are Mediated via FOXL1-positive Telocytes"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Short Talk Selected from Poster Abstracts
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Pnina Brodt (McGill University, Canada)
"Targeting the IGF Axis in Pediatric and Adult Glioma"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure