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IGF and Insulin System in Physiology and Disease

Gordon Research Conference

The IGF and Insulin System: From Basic Science to Clinical Translation and New Technologies

March 12 - 17, 2023

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Chairs Wendie Cohick and Victor K. Han

Vice Chairs Valentine Macaulay and Shoshana Yakar

Contact Chairs

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, CA, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by February 12, 2023. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The IGF and Insulin System in Physiology and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "IGF and Insulin System in Physiology and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Cellular Senescence and Aging: The Path to Translation Discussion Leader: Robert Baxter (University of Sydney, Australia)
7:40 pm - 8:25 pm	Phyllis Dennery (Brown University, United States) "The Many Faces and Impacts of Cellular Senescence"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	James Kirkland (Mayo Clinic, United States) "Cellular Senescence and Senolytics: The Path to Translation"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Early Life Origins of Health and Disease Discussion Leader: Stephen Matthews (University of Toronto, Canada)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	David Hill (Lawson Health Research Institute, Western University, London, Ontario, Canada) "Plasticity in the Endocrine Pancreas as a Response to Metabolic Demand"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Rebecca Simmons (University of Pennsylvania, United States) "The Ying and the Yang of ß-cell Programming"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am	Discussion
10:30 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	Miguel Constancia (University of Cambridge, United Kingdom) "Inter-organ Communication by IGFs: Gatekeepers for Metabolic Health"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	Malgorzata Borowiak (Adam Mickiewicz University, Poland) "Beta Cell Dedifferentiation and Diabetes"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer: Elisabeth Barton (University of Florida, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tissue Homeostasis and Regeneration: Stem Cells and Cell Plasticity Discussion Leader: Terri Wood (New Jersey Medical School, Rutgers University, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Cunming Duan (University of Michigan, United States) "Regulation of Epithelial Cell Plasticity by IGF and Calcium Signaling"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Jason Mills (Baylor College of Medicine, United States) "Paligenosis: An mTORC1-Dependent Plasticity Program Cells Use to Change Identity"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	Friedrich Metzger (Versameb Ltd., Switzerland) "IGF-I mRNA for Therapy: Regeneration of Muscle Tissue and Function in Stress Urinary Incontinence"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Role of IGF and Insulin in Nutrient Sensing Related to Lifespan and Disease Discussion Leader: Jeff Holly (University of Bristol, United Kingdom)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Matthew Piper (Monash University, Australia) "The Nutritional Requirements for Sustaining Life in Drosophila melanogaster"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Marc Tatar (Brown University, United States) "The Kinase Insert Domain of Drosophila dInr Regulates Aging Through Control of Methionine Metabolism"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Ruben Pio (Cima-University of Navarra, Spain) "Caloric Restriction and the IGF-I/IGF-1R Axis in Cancer Immunotherapy"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	Shin-Ichiro Takahashi (University of Tokyo, Japan) "Next Generation Nutritional and Feeding Science with Artificial Intelligence Techniques: Controlling Insulin-like Activity by Amino Acid Signaling"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	IGF and Insulin System in Development and Aging Discussion Leader: Briony Forbes (Flinders Medical Centre, Flinders University, Australia)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Derek Huffman (Albert Einstein College of Medicine, United States) "Intranasal Targeting with a Potent IGF-1 Analogue to Treat Alzheimer's Disease"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Richard Cubbon (University of Leeds, United Kingdom) "IGF-1 Signalling, the Vascular Endothelium and Atherosclerosis"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	Myriam Hemberger (University of Calgary, Canada) "The Key Role of the Placenta in Mitigating Congenital Defects and Ensuring Offspring Health"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Structure and Activation Mechanisms of Insulin, IGF and Hybrid Receptors: Recent Advances from Cryo-EM Discussion Leader: Pierre De Meyts (de Duve Institute, Belgium)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Xiaochen Bai (UT Southwestern Medical Center, United States) "Activation of the Insulin Receptor via Two Distinct Types of Sites"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Gerd Schluckebier (Novo Nordisk, Denmark) "Structural Investigations of Full-length Insulin Receptor Dynamics and Signaling"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Ünal Coskun (Center of Membrane Biochemistry and Lipid Research Dresden, Germany) "Cryo-EM Structure of the Complete and Ligand-saturated Insulin Receptor Ectodomain"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	Nicholas Kirk (Walter & Eliza Hall Institute of Medical Research, Australia) "How Ligands Bind to Insulin, IGF1 and Hybrid Receptors."
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The IGF and Insulin Axis and Cancer Discussion Leader: Derek Leroith (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Rosemary O'Connor (University College Cork, Ireland) "Control of IGF-1 Receptor Location in Cancer Cells: a Key to Function"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Claire Perks (University of Bristol, United Kingdom) "A role for the IGF axis in Amyloid Precursor Protein Processing in Cancer: Lessons Learnt from Alzheimer’s Disease"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	Emily Gallagher (Icahn School of Medicine at Mount Sinai, United States) "Insulin Receptor Isoforms and Signaling in Cancer"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Targeting the IGF and Insulin Axis in the Clinic Discussion Leader: Shoshana Yakar (New York University College of Dentistry, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Douglas Yee (Masonic Cancer Center, University of Minnesota, United States) "What Happened to Targeting IGF-1R in Cancer?"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Joseph Ludwig (MD Anderson Cancer Center, United States) "Cotargeting the IGF-1/PI3K/mTOR Pathway in Ewing Sarcoma: Is the Story Over or Has it Just Begun?"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am	Discussion
10:30 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	Guido Kroemer (University of Paris Cité, France) "Inhibition of IGF1 Receptor Signaling Improves Cardiac and Immune Functions"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	Terry Smith (University of Michigan, United States) "IGF-1 Receptor; Mischief Maker?"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: New Methodologies to Advance IGF and Insulin Research Discussion Leaders: David Clemmons (UNC School of Medicine, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:15 pm	Klaus Kaestner (University of Pennsylvania, United States) "Growth Effects of IGF-1 in the Gut are Mediated via FOXL1-positive Telocytes"
8:15 pm - 8:25 pm	Discussion
8:25 pm - 8:35 pm	Short Talk Selected from Poster Abstracts
8:35 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	Pnina Brodt (McGill University, Canada) "Targeting the IGF Axis in Pediatric and Adult Glioma"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History IGF and Insulin System in Physiology and Disease (GRS) Contribute Financially to This Conference

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Diversity Funding

Financial assistance is available for qualified applicants through the GRC Carl Storm Underrepresented Minority Fellowship Program. This program provides a grant to underrepresented minority graduate students, postdocs, faculty and scientists to help fund their attendance at their first GRC meeting. Learn more.

Registration Fees

Conferee Single Room:

$1,595.00

Conferee Shared Room:

$1,295.00

Conferee Off-Site:

$880.00

Guest Single Room:

$1,405.00

Guest Shared Room:

$1,105.00

Guest Off-Site:

$690.00

Child 4-12 yrs Shared Room:

$553.00

Child 4-12 yrs Off-Site:

$345.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Additional Fee Info

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IGF and Insulin System in Physiology and Disease (GRS)

March 11 - 12, 2023

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