Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cellular Senescence and Aging: The Path to Translation
Discussion Leader: Robert Baxter (University of Sydney, Australia)
7:40 pm - 8:25 pm
Phyllis Dennery (Brown University, United States)
"The Many Faces and Impacts of Cellular Senescence"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
James Kirkland (Mayo Clinic, United States)
"Cellular Senescence and Senolytics: The Path to Translation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of IGF and Insulin in Metabolism and Diabetes
Discussion Leader: Shoshana Yakar (NYU, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
David Hill (Lawson Health Research Institute, Western University, London, Ontario, Canada, Canada)
"Plasticity in the Endocrine Pancreas as a Response to Metabolic Demand"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Rebecca Simmons (University of Pennsylvania, Perleman School of Medicine, United States)
"The Ying and the Yang of ß-cell Programming"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Miyuki Suzawa (University of Virginia Dept. of Pharmacology, United States)
"Dietary Sugar and Protein Exert Opposing Effects on Key Growth and Metabolic Regulators in Drosophila, the Insulin and IGF1 Homologs Dilp2 and Dilp6"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Miguel Constancia (University of Cambridge, United Kingdom)
"Inter-Organ Communication by IGFs: Gatekeepers for Metabolic Health"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Guri Tzivion (American University of Antigua College of Medicine, Antigua and Barbuda)
"The Nicotinamide/NAD-Sirtuin Pathway as a Target in Obesity and Metabolic Disorders"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Malgorzata Borowiak (Adam Mickiewicz University, Poland)
"Beta Cell Dedifferentiation and Diabetes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Elisabeth Barton (University of Florida, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Homeostasis and Regeneration: Stem Cells and Cell Plasticity
Discussion Leader: Victor Han (Children's Health Research Institute, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Cunming Duan (University of Michigan, United States)
"Regulation of Epithelial Cell Plasticity by IGF and Calcium Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Elisabeth Barton (University of Florida, United States)
"CRISPR Mediated Ablation of Specific IGF-1 Forms Uncovers the Importance of Glycosylation for Muscle Storage and Cleavage for Regenerative Capacity"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Jason Mills (Baylor College of Medicine, United States)
"Paligenosis: An mTORC1-Dependent Plasticity Program Cells Use to Change Identity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Desmond Mascarenhas (Mayflower Organization for Research and Education, United States)
"Episynchrons: Translational Harnessing of the Immunoregenerative Potential of IGFBP-Derived Immodulin Peptides"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The IGF and Insulin Axis and Cancer
Discussion Leader: Derek Leroith (Mt sinai, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Rosemary O'Connor (University College Cork, Ireland)
"Control of IGF-1 Receptor Location in Cancer Cells: A Key to Function"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Ernestina De Francesco (University of Catania, Italy)
"RAGE Inhibition Halts Insulin Signals in Breast Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Ji-Sun Lee (UMass Medical School, United States)
"Function of PLK-1-IRS2 Interaction in Breast Cancer Progression"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Ashwin Nandakumar (University of Oxford, United Kingdom)
"IGFs Regulate Tumour-Intrinsic Components of the Immune Response to Promote an Immunosuppressive Microenvironment in Prostate Cancer"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Claire Perks (University of Bristol, United Kingdom)
"Targeting IGF/IR Signaling Enhances the Efficacy of 5FU in Colorectal Cancer Cells: A Role for IGFBP-3 and GRP78"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Caterina Mancarella (IRCCS Istituto Ortopedico Rizzoli, Italy)
"The RNA-Binding Protein IGF2BP3 Modulates the Aggressiveness of Ewing Sarcoma by Dynamically Regulating IGFR Signaling"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Emily Gallagher (Icahn School of Medicine at Mount Sinai, United States)
"Insulin Receptor Isoforms and Signaling in Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 12:40 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin System in Development and Aging
Discussion Leader: Briony Forbes (Flinders Medical Centre, Flinders University, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Derek Huffman (Albert Einstein College of Medicine, United States)
"Intranasal Targeting with a Potent IGF-1 Analogue to Treat Alzheimer's Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Jaetaek Kim (Chung-Ang University, South Korea)
"Insulin Signaling is Critical for Sinoatrial Node Maintenance and Function"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Cameron Dixon (Boston University, United States)
"Understanding Peripheral Disturbances Following Traumatic Injury Using Drosophila"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Qi Hao (Calico life science, United States)
"Recognition Mechanism of IGF Binding Protein-5 by the Proteolytic Enzyme PAPP-A"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure and Activation Mechanisms of Insulin, IGF and Hybrid Receptors: Recent Advances from Cryo-EM
Discussion Leader: Pierre De Meyts (de Duve Institute, Belgium)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Xiaochen Bai (UT Southwestern Medical Center, United States)
"Activation of the Insulin Receptor via Two Distinct Types of Sites"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Irena Selicharova (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)
"Insulin Receptor Arg717 and IGF-1 Receptor Arg 704 Play Key Role in Ligand Binding and in Receptor Activation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Gerd Schluckebier (Novo Nordisk, Denmark)
"Structural Investigations of Full-Length Insulin Receptor Dynamics and Signaling"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Ünal Coskun (University Hospital and Carl Gustav Carus School of Medicine, TU Dresden, Germany)
"Cryo-EM Structure of the Complete and Ligand-Saturated Insulin Receptor Ectodomain"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Christopher Galifi (Rutgers New Jersey Medical School, United States)
"Understanding the Unique Roles of the Insulin Receptor Isoforms in Breast Cancer"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Briony Forbes (Flinders Medical Centre, Flinders University, Australia)
"The Cone Snail Story: Current Understanding of How Insulin and IGFs Activate Their Receptors"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nutrient Sensing Related to Lifespan and Disease
Discussion Leader: Jeff Holly (University of Bristol, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Marc Tatar (Brown University, United States)
"The Kinase Insert Domain of Drosophila dInr Regulates Aging Through Control of Methionine Metabolism"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Martina Chrudinova (Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Czech Republic)
"Mandarin Fish Ranavirus Viral Insulin/IGF-Like Peptide Inhibits Human IGF1R Phosphorylation in High Concentrations and Regulates IGF1R Gene Expression"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Fumihiko Hakuno (The University of Tokyo, Japan)
"Alternative Splicing Regulation of Insulin Receptor in Response to Amino Acid"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Ruben Pio (Cima-University of Navarra, Spain)
"Caloric Restriction and the IGF-I/IGF-1R Axis in Cancer Immunotherapy"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Targeting the IGF and Insulin Axis in the Clinic
Discussion Leader: Valentine Macaulay (University of Oxford, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Douglas Yee (Masonic Cancer Center, University of Minnesota, United States)
"What Happened to Targeting IGF-1R in Cancer?"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Yosuke Yoneyama (Tokyo Medical and Dental University, Japan)
"IGFALS Regulates Non-Alcoholic Steatohepatitis Progression in Mouse, Organoid and Human"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Joseph Ludwig (MD Anderson Cancer Center, United States)
"Cotargeting the IGF-1/PI3K/mTOR Pathway in Ewing Sarcoma: Is the Story Over or Has it Just Begun?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Guido Kroemer (University of Paris Cité, France)
"Inhibition of IGF1 Receptor Signaling Improves Cardiac and Immune Functions"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Cristiana IOSEF (London Health Science Center, Canada)
"Plasma Proteome of Long-COVID Patients Indicates Hypoxia Mediated Vasculoproliferative Disease Potentially Mediated by the IGF System"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Terry Smith (University of Michigan, United States)
"IGF-1 Receptor: Mischief Maker?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Methodologies to Advance IGF and Insulin Research
Discussion Leader: David Clemmons (UNC School of Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Shin-Ichiro Takahashi (University of Tokyo, Japan)
"Next Generation Nutritional and Feeding Science with Artificial Intelligence Techniques: Controlling Insulin-Like Activity by Amino Acid Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Na-Oh Yunn (Pohang University of Science and Technology, South Korea)
"Functional Selectivity of Insulin Receptor Revealed by Aptamer-Trapped Receptor Structures"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Pnina Brodt (McGill University, Canada)
"Targeting the IGF Axis in Pediatric and Adult Glioma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Takafumi Miyamoto (University of Tsukuba, Japan)
"Rapid Manipulation of Mitochondrial Morphology in a Living Cell with iCMM"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
