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WELCOME RECEPTION BEFORE DINNER
June 29 (pm)
(7:30-9:40)
TCR STRUCTURE/FUNCTION RELATIONSHIPS
- I. Wilson, Chair - Introduction
- I. Wilson - "Structures of TCRs and TCR complexes"
- J. Kappler - "T cell receptor ligand interactions"
- K. Karjalainen - "TCR affinity and function"
- E. Reinherz - "TCR antibody interactions at atomic resolution"
LYMPHOCYTE DEVELOPMENT
June 30 (am)
(9:00-12:30)
- M. Owen, Chair - Introduction
- M. Owen - "Regulation of early thymocyte development"
- D. Mathis - "Positive selection of T cells"
- Coffee Break
- R. Hayakawa - "Function of pre-B receptor in fetal and adult B lymphopoiesis"
- M. Nussenzweig - "Immunoglubulins and B cell development"
GENERATION OF DIVERSITY
June 30 (pm)
(7:30-9:30)
- M. Oettinger, Chair - Introduction
- M. Oettinger - "First steps in V(D)J recombination"
- D. Roth - "Investigating the role of Ku in V(D)J recombination"
- M. Weigert - "Receptor Editing"
- A. Radbruch - "Targeting of Ig class switch recombination"
- M. Neuberger - "Antibody diversification by somatic hypermutation"
POSITIVE/NEGATIVE REGULATION OF SIGNALING
July 1 (am)
(9:00-12:30)
- D. Fearon, Chair - Introduction
- J. Allison - "Mechanism and consequences of costimulatory and inhibitory signals in T cell activation"
- G. Koretsky - "Regulation of T cell receptor mediated-signal transduction by SLP-76 and SLAP-130"
- Coffee Break
- J. Ravetch - "Distinct signaling pathways for FcR and KIR"
- M. C. Carroll - "The CD21 coreceptor regulates both activation and elimination of B lymphocytes"
- D. Fearon - "Positive feedback regulation of intracellular Ca2+ by CD19"
POSTER SESSION
July 1 (pm)
(4:30-6:00)
TCR structure/function relationships, Lymphocyte development, Generation of Diversity
LYMPHOID ORGAN DEVELOPMENT
(7:30-9:30)
- D. Chaplin, Chair - Introduction
- D. Chaplin - "Lymphotoxin, a primary determinant of lymphoid tissue structure"
- J. Browning - "Delineation of a LTalpha/beta-independent subset of lymph nodes that drain mucosal surfaces"
- J. Sedgwick - "A distinct role for tumor necrosis factor in organogenesis and special organisation of lymphoid tissue"
- Grouped Discussion
- T. Böehm - "The nude gene and thymus development"
- C. Clegg - "Regulation of an extrathymic T cell development pathway by oncostatin M"
SIGNALING APOPTOSIS
July 2 (am)
(9:00-12:30)
- C. Thompson, Chair - Introduction
- P. Marrack - "Lifejackets for T cells"
- C. Thompson - "How do cells decide whether to live or die in response to TNF?"
- D. Perkins - "Fas modulation of apoptosis during negative selection of thymocytes"
- Coffee Break
- X. Wang - "Cytochrome c: A double agent for life and death"
- P. Henkart - "Do cytotoxic T cells induce apoptosis?"
- P. Ashton-Rickardt - "The role of positive selection in the generation of immunologic memory"
POSTER SESSION
July 2 (pm)
(4:30-6:00)
Positive/negative regulation of signalling, Signalling apoptosis, Chemokines, Host/pathogen interactions, Antigen processing and presentation, Miscellaneous
SPECIAL TOPIC: THE CELL CYCLE
July 2 (pm)
(7:30-9:30)
- E. Harlow - "RB's role in G1 control"
- Break + Business Meeting
- A. Weis-Amon - "Regulation of cell cycle progression by proteolysis"
CHEMOKINES
July 3 (am)
(9:00-12:30)
- C. Mackay, Chair - Introduction
- E. Butcher - "The next steps in leukocyte trafficking: the combinatorial control of chemotaxis"
- N. Gerard - "Chemoattractant receptors and host defense. From viruses to bacteria"
- P. Ponath - "Chemokine receptors: therapeutic targets for AIDS and asthma"
- Coffee Break
- J-C. Gutierrez-Ramos - "Chemokines in disease: direct effects on tissue resident cells vs. recruitment of inflammatory leukocytes"
- C. Bleul - "In vivo chemotaxis in B lymphocytes: implications for positioning of lymphocytes within secondary lymphoid organs"
- U. Forssmann - "Characterization of a novel cc chemokine with three disulfide bonds"
HOST/PATHOGEN INTERACTIONS
July 3 (pm)
(7:30-9:30)
- D. Littman, Chair - Introduction
- H. Ploegh - "Proteolysis and the immune system: new insights, new surprises"
- N. Glaichenhaus - "Protective and detrimental T cell responses in murine leishmaniasis"
- D. Littman - "Chemokine receptors and HIV pathogenesis: is it the chicken or the egg?"
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