| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Immune Cell Development and Renewal |
| Discussion Leader: Cynthia Guidos (Hospital for Sick Children, U of Toronto) |
| 7:40 pm - 8:00 pm | Cynthia Guidos (Hospital for Sick Children, U of Toronto)
"Functions of Notch Signaling in Programming 'Innate-Like' Lymphocyte Effector Functions"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Paul Frenette (Albert Einstein College of Medicine, Yeshiva University, New York)
"A Novel Pro-Inflammatory Neutrophil Subset"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:50 pm | Livija Deban (London Research Institute, Cancer Research UK)
"An Epithelial Determinant Required for the Development of Signatory Murine Intestinal Intraepithelial T Cells"
|
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Miriam Merad (Mt Sinai University Hospital, New York)
"Macrophage are Critical for the Maintenance of Tissue Homeostasis"
|
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of Immune Cells and Systems |
| Discussion Leader: Gillian Griffiths (University of Cambridge) |
| 9:00 am - 9:25 am | Gillian Griffiths (University of Cambridge)
"Ordering Events Leading to CTL Killing"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Madeleine Hipp (University of Oxford)
"Novel Insights into the Biology of Human Toll-Like Receptor 7"
|
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Daniel Popkin (Case Western Reserve University)
"Combating Persistent Viral Infections with Dendritic Cell-Specific Protease Inhibition"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:30 am - 11:00 am | Ruslan Medzhitov (Yale University)
"New Perspectives on the Regulation of Immune Responses"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Art Weiss (U California, San Francisco)
"Controlling Kinases that Interact with the T Cell Receptor"
|
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Reinhold Förster (University of Hannover, Germany)
"Homing of Immune Cells via Afferent Lymphatics: A Novel Role for CCRL1 in Creating Gradients for CCR7 Ligands" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Immunology and Metabolism |
| Discussion Leader: Erika Pearce (Washington University, St Louis) |
| 7:30 pm - 8:00 pm | Erika Pearce (Washington University, St Louis)
"Metabolic Regulation of T Cell Function and Fate" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Claudia Kemper (King's College, London)
"Complement as a Key Controller of Basic Metabolic Processes in CD4+ T Cells" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Peter Ghazal (University of Edinburgh)
"Coupling of Interferon Response to Sterol Metabolism"
|
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Ludvig Sollid (Oslo University Medical Centre, Norway)
"Celiac Disease: When Food Is the Problem" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Memory in Innate and Adaptive Cells |
| Discussion Leader: Federica Sallusto (Institute for Biomedical Research, Bellinzona) |
| 9:00 am - 9:25 am | Federica Sallusto (Institute for Biomedical Research, Bellinzona)
"Human Memory T Cell Subsets in Immunity and Autoimmunity"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Daniel Utzschneider (Swiss Vaccine Research Institute)
"Linking Functional Diversity and TCR Signal Strength in Chronic Infections"
|
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Robert Kimmerling (MIT)
"A Toolset for Multigenerational Lineage Characterization of Single CD8+ T Cells"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:30 am - 11:00 am | Susan Kaech (Yale University)
"The Top 10 Ways to Help Memory CD8 T Cells Develop"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Erin Adams (University of Chicago)
"Antigenic Signals that Regulate Gamma Delta T Cells in Human Health and Disease" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Hans-Gustaf Ljunggren (Karolinska Institute)
"Not So Innate Immune Reactions by NK Cells in Human Viral Infections"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Immunity Within Tissues |
| Discussion Leader: Yasmine Belkaid (National Institutes of Health, Bethesda) |
| 7:30 pm - 8:00 pm | Yasmine Belkaid (National Institutes of Health, Bethesda)
"Compartmentalized Control of Tissue Immunity by Commensals"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Dan Littman (Skirball Institute, New York University)
"Mechanisms of Microbiota-Directed Effector T Cell Differentiation"
|
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Scott Mueller (University of Melbourne, Australia)
"Surveillance and Protective Responses by Skin Tissue-Resident Memory T Cells"
|
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Wendy Garrett (Harvard University)
"Microbial Metabolites and Gut Immune Homeostasis"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Human Immunobiology |
| Discussion Leader: Rafi Ahmed (Emory University) |
| 9:00 am - 9:25 am | Rafi Ahmed (Emory University)
"Immune Memory to Vaccines"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Alex Sigal (Max Planck Institute of Infection Biology & University of KwaZulu-Natal, S.Africa)
"Determinants of Mycobacterium tuberculosis Control in Macrophages"
|
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Zaza Ndhlovu (Harvard University & Nelson Mandela School of Medicine, KwaZulu-Natal)
"T Cell Immunity in Acute HIV Subtype C Infection, Implications for the Development of an Effective AIDS Vaccine"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:30 am - 11:00 am | Danny Douek (National Institutes of Health, Bethesda)
"Type I Interferon Signaling in SIV Infection"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Antonio Lanzavecchia (Institute for Biomedical Research, Bellinzona)
"Affinity Maturation of Broadly Neutralizing Antibodies" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Mark Davis (Stanford U., California)
"Immunology for the People: Studying the Immune System as a 'System'"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Immunity in the Very Young |
| Discussion Leader: Juan Carlos Zuniga-Pflucker (University of Toronto) |
| 7:30 pm - 8:00 pm | Trevor Burt (University of California, San Francisco)
"Human Fetal T Cell Development and Its Impact on Neonatal Immune Function"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Juan Carlos Zuniga-Pflucker (University of Toronto)
"In Vitro Model of Human T Cell Development for Primary Immune Deficiencies"
|
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Deena Gibbons (King's College London)
"Interleukin-8 (CXCL8) Production is a Signatory T Cell Effector Function of Human Newborn Infants"
|
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Arnaud Marchant (Institute of Medical Immunology, Free University of Brussels)
"Anti-Viral Immunity During Fetal Life"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | The Mechanisms of Cytokine Action |
| Discussion Leader: Fiona Powrie (Oxford University) |
| 9:00 am - 9:25 am | Fiona Powrie (Oxford University)
"Gut Reactions: Immune Pathways in the Intestine in Health and Disease"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Heather Pua (UCSF)
"Coordinate Regulation of Th2 Cell IL-4 Production by miR-23 Cluster miRNAs"
|
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Marie Wehenkel (St Jude's Children's Research Hospital)
"Erk2 is a Critical Regulator of Spontaneous Osteochondromas"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:30 am - 11:00 am | Hergen Spits (University of Amsterdam)
"Regulation of Cytokine Production by Human Innate Lymphoid Cell Subsets"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Jose-Carlos Gutierrez-Ramos (Pfizer)
"Novel Human Pharmacology and Clinical Immunology Revealed Through Differential Inhibition of JAK Pathway Kinases" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Ajay Chawla (University of California, San Francisco)
"Type 2 Immunity and Metabolism"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Tumor Immunology |
| Discussion Leader: Padmanee Sharma (MD Anderson Cancer Centre, Texas) |
| 5:30 pm - 6:00 pm | Jim Allison (MD Anderson Cancer Centre, Texas)
"Immune Checkpoint Blockade in Cancer Therapy: New Insights and Opportunities"
|
| 6:00 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:35 pm | Padmanee Sharma (MD Anderson Centre, Texas)
"Anti-CTLA-4 and Anti-PD-1/PD-L1 Therapies: Clinical Data and Immune Monitoring Results"
|
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 6:55 pm | TBA
|
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Kai Wucherpfennig (Dana Farber Cancer Center, Harvard)
"In Vivo Discovery of Novel Targets for Immunotherapy"
|
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |