Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Visualizing Filament Organization and Dynamics at the Nanoscale
Discussion Leader: Harald Herrmann (German Cancer Research Center (DKFZ), Germany)
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7:40 pm - 7:55 pm |
Opening Remarks
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7:55 pm - 8:00 pm |
Introduction by Discussion Leader
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8:00 pm - 8:20 pm |
Birgit Lane (Skin Research Institute of Singapore, A*STAR, Singapore)
"Keratin Dynamics and Disease Mechanisms"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Ohad Medalia (University of Zurich, Switzerland)
"The Structure of Vimentin Filament Using In Situ, Ghost Cells and In Vitro Analysis"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, United States)
"Vimentin Cytoskeletal Dynamics and its Role ER Organization"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Functional Insights into the Structure and Biophysics of Intermediate Filaments
Discussion Leader: Diana Toivola (Abo Akademy University, Finland)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:25 am |
Christopher Bunick (Yale University, United States)
"Keratin Structurotype and How it Drives Human Disease Pathogenesis"
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9:25 am - 9:35 am |
Discussion
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9:35 am - 9:55 am |
Sarah Koester (University of Göttingen, Germany)
"Intermediate Filament Mechanics – From Single Filaments to Networks (in cells)"
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9:55 am - 10:05 am |
Discussion
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10:05 am - 10:15 am |
Ben Fabry (University of Erlangen Nürnberg, Germany)
"Dissecting the Lateral and Longitudinal Assembly Kinetics of Vimentin with a Dual Wavelength Stopped-flow Approach"
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10:15 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:10 am |
Steve McKnight (University of Texas Southwestern Medical Center, United States)
"Self-Association of IF Head Domains as a Paradigm for Understanding the Relevance of Phase Separation to Cell Biology"
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11:10 am - 11:20 am |
Discussion
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11:20 am - 11:30 am |
Stephanie Portet (University of Manitoba, Canada)
"A General Mathematical Model for the in vitro Assembly Dynamics and Intracellular Transport of Cytoplasmic IF Proteins"
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11:30 am - 11:35 am |
Discussion
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11:35 am - 11:45 am |
Suganya Sivagurunathan (Northwestern University, United States)
"Expression of Vimentin Alters Cell Mechanics, Cell-cell Adhesion, and Gene Expression Profiles Suggesting the Induction of a Hybrid EMT in Human Mammary Epithelial Cells"
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11:45 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Late-Breaking Topic
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12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:30 pm |
Poster Previews
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Karen Ridge (Northwestern University, United States) and Sarah Koester (University of Göttingen, Germany)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Signaling and Cytoskeletal Crosstalk by Intermediate Filaments
Discussion Leader: Sandrine Etienne-Manneville (Institut Pasteur / CNRS, France)
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7:30 pm - 7:50 pm |
Gaudenz Danuser (University of Texas Southwestern Medical Center, United States)
"Probing the Functional Link Between Shifts in Keratin Composition and Cell Mechanics During Epidermal Remodeling"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Ming Guo (Massachusetts Institute of Technology, United States)
"Intermediate Filaments as Integrator of Cytoskeletal Mechanics"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Pierre Thibault (Universite de Montreal, Canada)
"SUMOylation of Intermediate Filaments and Cell Motility"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
John Eriksson (Åbo Akademi University, Finland)
"Vimentin at the Crossroads of Signaling, Metabolism, and Migration"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Connecting the Nucleus, Cytoskeleton and Extracellular Environment
Discussion Leader: Gregg Gundersen (Columbia University Medical Center, United States)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:25 am |
Catherine Shanahan (King's College London, United Kingdom)
"Nesprins and Lamins LINC the Nucleus and Aging"
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9:25 am - 9:35 am |
Discussion
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9:35 am - 9:55 am |
Daniel Starr (University of California, Davis, United States)
"New Insights Into the Force Transmission Across the Nuclear Envelope"
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9:55 am - 10:05 am |
Discussion
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10:05 am - 10:15 am |
Emma Carley (Yale University, United States)
"Loss of SUN2 is Protective Against Injury-induced Lung Fibrosis"
|
10:15 am - 10:20 am |
Discussion
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10:20 am - 10:25 am |
General Discussion
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10:25 am - 10:55 am |
Coffee Break
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10:55 am - 11:15 am |
Kathleen Green (Northwestern University, United States)
"The Desmosome as Cellular Integrator and Sensor"
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11:15 am - 11:25 am |
Discussion
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11:25 am - 11:35 am |
Noam Zuela - Sopilniak (Cornell University, United States)
"Don’t Go Breaking My Heart – How LMNA Mutations Cause Heart Disease"
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11:35 am - 11:40 am |
Discussion
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11:40 am - 11:50 am |
Zanetta Kechagia (Institut de Bioenginyeria de Catalunya, Spain)
"The Laminin-keratin Link Shields the Nucleus from Mechanical Deformation and Signalling"
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11:50 am - 11:55 am |
Discussion
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11:55 am - 12:05 pm |
Vivek Shenoy (University of Pennsylvania, United States)
"Vimentin Intermediate Filaments Integrate Actomyosin Contractility with Microtubule Stiffness in Cellular Response to Substrate Mechanics"
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12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Integration of Muscle Mechanobiology by Intermediate Filaments in Health and Disease
Discussion Leader: Dennis Discher (University of Pennsylvania, United States)
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7:30 pm - 7:50 pm |
Shenhav Cohen (Technion - Israel Institute of Technology, Israel)
"Desmin Intermediate Filament Depolymerization is Required for Myosin and Actin Loss and Muscle Wasting"
|
7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Lori Wallrath (University of Iowa, United States)
"Mutant Lamins Cause Loss of Myonuclear Microtubule Caging and Nuclear-Cytoskeletal Coupling"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:40 pm |
Daria Amiad Pavlov (University of Pennsylvania, Perelman School of Medicine, Department of Physiology, United States)
"Dynamic Nuclear-sarcomeric Coupling in the Adult Cardiac Muscle"
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8:40 pm - 8:45 pm |
Discussion
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8:45 pm - 8:55 pm |
Yin Loon Lee (Nuevocor Pte Ltd and A*STAR, Singapore, Singapore)
"Genetic Evidence for the LINC Complex as a Safe Therapeutic Target in Laminopathies"
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8:55 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Brian Glancy (National Institutes of Health, United States)
"Sustaining Power: Building Energy Networks in Striated Muscle Cells"
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9:20 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Linking Intermediate Filaments to Neurodegenerative Diseases
Discussion Leader: Ronald Liem (Columbia University, United States)
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9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:25 am |
Pascale Bomont (Inserm- NeuroMyoGene institut (INMG), France)
"Neurofilament Dynamics in Health and Disease"
|
9:25 am - 9:35 am |
Discussion
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9:35 am - 9:55 am |
Sanjay Kumar (University of California, Berkeley, United States)
"Reconstituted Neurofilament brushes: Insights into Disorder and Mechanobiology"
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9:55 am - 10:05 am |
Discussion
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10:05 am - 10:15 am |
Werner Dykstra (University Medical Center Utrecht, The Netherlands)
"Advanced Brain Organoid Modeling of Mutant GFAP"
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10:15 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:10 am |
Jean-Pierre Julien (Laval University, Canada)
"Connecting IFs and Amyotrophic Lateral Sclerosis"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:40 am |
Milos Pekny (University of Gothenburg, Sweden)
"Astrocyte Intermediate Filaments and the Two-Edged Sword of Reactive Gliosis in Stroke"
|
11:40 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Quasar Padiath (University of Pittsburgh, United States)
"A novel upstream genomic element regulates tissue specificity of Lamin B1 overexpression in Autosomal Dominant Leukodystrophy"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Progenitors, Senescence and Cancer
Discussion Leader: Dennis Roop (University of Colorado Anschutz Medical Campus, United States)
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7:30 pm - 7:50 pm |
Pierre Coulombe (University of Michigan, United States)
"Keratin-Dependent Regulation of Innate Immunity in Skin"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:10 pm |
Susana Gonzalo (Saint Louis University, United States)
"Linking genomic instability, sterile inflammation, and metabolic problems in laminopathies "
|
8:10 pm - 8:15 pm |
Discussion
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8:15 pm - 8:35 pm |
Ganna Bilousova (University of Colorado Anschutz Medical Campus, United States)
"Skin Progenitor Cell Therapies – Personalized Medicine at its Most Potent"
|
8:35 pm - 8:45 pm |
Discussion
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8:45 pm - 8:55 pm |
Annica Gad (University of Sheffield, United Kingdom)
"Metastasising fibroblasts show an HDAC6-dependent increase in migration speed and loss of directionality linked to major changes of the vimentin interactome"
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8:55 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Andy Xiang (Sun Yat-sen University, China)
"Progenitor Cell Renewal and Retention Requires Nestin"
|
9:20 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Mechanistic Insights into Intermediate Filament Diseases
Discussion Leader: Cecilia Sahlgren (Åbo Akademi University, Finland)
|
9:00 am - 9:05 am |
Introduction by Discussion Leader
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9:05 am - 9:25 am |
Karen Ridge (Northwestern University, United States)
"The Interaction Between Vimentin, Ferroptosis and Lipid Metabolism in Lung Cancer"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 9:55 am |
Nicole Schwarz (RWTH Aachen University, Germany)
"Keratins as Regulators of Mitochondrial Quality Control"
|
9:55 am - 10:05 am |
Discussion
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10:05 am - 10:15 am |
Lauri Polari (Åbo Akademi University, Finland)
"Colonic epithelial keratin 7 expression increases de novo in a subset of inflammatory bowel disease"
|
10:15 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:10 am |
Dolores Perez-Sala (Consejo Superior de Investigaciones Científicas (CSIC), Spain)
"Redox Tuning of IF Function Through Posttranslational Modifications"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:30 am |
Linghai Kong (UW-Madison, United States)
"GFAP Interacts With and Regulates Vesicular Trafficking and Secretion in Human Astrocytes"
|
11:30 am - 11:35 am |
Discussion
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11:35 am - 11:45 am |
Darcie Moore (University of Wisconsin-Madison, United States)
"Vimentin protein contributes to quiescent neural stem cell exit through proteasome relocalization to the aggresome and protein clearance"
|
11:45 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Jason Choi (Thomas Jefferson University, United States)
"Interplay of Stress Responses Underlying the Development of LMNA Cardiomyopathy"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Emerging Therapeutic Approaches for Intermediate Filament-Based Diseases
Discussion Leader: Gisele Bonne (Sorbonne Université , France)
|
7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
7:35 pm - 7:55 pm |
Colin Stewart (A*STAR SingaporeA, Singapore)
"LINC Complex Disruption as a Therapeutic Target for Laminopathies"
|
7:55 pm - 8:05 pm |
Discussion
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8:05 pm - 8:25 pm |
Antoine Muchir (INSERM, France)
"Modulating Cytoskeleton Dynamics to Treat Cardiomyopathy Caused by LMNA Mutations"
|
8:25 pm - 8:35 pm |
Discussion
|
8:35 pm - 8:45 pm |
Alison Patteson (Syracuse University, United States)
"Extracellular Vimentin as a Target Against SARS-CoV-2 Host Cell Invasion"
|
8:45 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:05 pm |
Thomas Magin (Leipzig University, Germany)
"A Chemical Compound-based Therapy Approach for Epidermolysis Bullosa Simplex"
|
9:05 pm - 9:10 pm |
Discussion
|
9:10 pm - 9:20 pm |
General Discussion
|
9:20 pm - 9:30 pm |
Closing Remarks
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|