Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Disease and Human Diversity
Discussion Leader: Birgit Lane (Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:30 pm
Kari Stefansson (deCODE genetics, Iceland)
"From Understanding of the Molecular Foundation of Human Diversity to Understanding of Human Health and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Ronald Liem (Columbia University, United States)
"Neuronal Intermediate Filaments in Health and Disease"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nanostructure of Life
Discussion Leader: Colin Stewart (A*STAR Skin Research Labs, Singapore, Singapore)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Gregg Gundersen (Columbia University Medical Center, United States)
"How the Lamina Partners With the LINC Complex for Nuclear Mechanotransduction"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Baihui Wang (University of Zurich, Switzerland)
"The Molecular Basis of Lamin Interactions with Nucleosomes and Chromatin"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Amy Beedle (King's College London, United Kingdom)
"Fibrillar Adhesion Dynamics Govern the Timescales of Nuclear Mechano-Response via the Vimentin Cytoskeleton"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Dek Woolfson (University of Bristol, United Kingdom)
"Designing Cell-Penetrating Peptides to Engage the Cytoskeleton"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Ayana Yamagishi (National Institute of Advanced Industrial Science and Technology, Japan)
"Analysis of Mechanical Properties of Nestin Tail Domain Using Atomic Force Microscopy"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Chang-Hun Lee (Daegu Gyeongbuk Institute of Science and Technology, South Korea)
"Structural Models of Unexplored Domains of Keratin Proteins"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Anders Aufderhorst-Roberts (Durham University, United Kingdom)
"Probing the Dynamic Mechanics of Cell-Free Vimentin Networks Using Microrheology and Microfluidics"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Noam Zuela-Sopilniak (Cornell University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cancer and Development
Discussion Leader: Milos Pekny (University of Gothenburg, Sweden)
6:00 pm - 6:20 pm
Sandrine Etienne-Manneville (Institut Pasteur / CNRS, France)
"Cytoskeletal Crosstalk in Cell Adhesion"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Minh Tri Ho Thanh (Syracuse University, United States)
"Vimentin Intermediate Filaments Enhances Collective Cell Migration Through Three-Dimensional Extracellular Matrix Networks"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Suyash Naik (Institute for Science and Technology, Austria, Austria)
"Mechanosensitive Crosstalk Between Keratin IFs and Contractility Mediates Zebrafish Epithelial Morphogenesis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Nilüfer Düz (Hacttepe University, Turkey)
"Beyond the Cytoplasm: Exploring Desmin's Nuclear Dynamics and Regulatory Functions in Muscle Physiology"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Emma van Bodegraven (University Medical Center, Utrecht Brain Center, The Netherlands)
"Brain Tumour-Astrocyte Interaction and the Role of the Astrocytic IF Network"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Nicolas Plachta (University of Pennsylvania, United States)
"Imaging the Cytoskeletal Dynamics that Pattern the Early Mammalian Embryo"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biophysics and Bioengineering
Discussion Leader: Ohad Medalia (University of Zurich, Switzerland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Jan Lammerding (Cornell University, United States)
"New Insights Into Ultra-Rapid Nuclear Mechanotransduction and the Function of Lamins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Dennis Discher (University of Pennsylvania, United States)
"Lamin-B1: Curvature and Evolution"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Lovis Schween (Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany)
"Desmin Filament Assembly Characteristics and the Loss of Elongation Control in Mutant R406W"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Gijsje Koenderink (Delft University of Technology, The Netherlands)
"How Intermediate Filaments Make Cells Strong"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Giovanna Lattanzi (CNR Institute of Molecular Genetics, Luigi Luca Cavalli-Sforza, Italy)
"Cross-Talk Between Nuclear and Cytoplasmic Intermediate Filaments in Muscle Cells Under Mechanical Stress Conditions"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Claira Sohn (University of Texas Health, San Antonio, United States)
"Investigating the Effects of Pathogenic Tau on Nuclear Mechanotransduction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Ulrika Wilhelmsson (University of Gothenburg, Sweden)
"Attenuation of Reactive Gliosis by Genetic Ablation of GFAP and Vimentin Improves Survival and Slows Down ALS Progression"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Muscular Dystrophies and Cardiomyopathies
Discussion Leader: Antoine Muchir (Inserm, France)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Onnik Agbulut (Sorbonne Université, France)
"The Remarkable Story of Desmin in the Heart: Special Focus on Cardiomyopathy and Future Therapies"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Bernhard Kühn (Children's Hospital of Pittsburgh, United States)
"Interdependent Changes of Nuclear Lamins, Nuclear Pore Complexes, and Ploidy Regulate Cellular Regeneration and Stress Response in the Heart"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Qi Jin (Columbia University, United States)
"Deciphering the Role of Nuclear Lamina Proteins Associated with Emery-Dreifuss Muscular Dystrophy Using iPSC Induced Cardiomyocytes"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
Elisa Di Pasquale (National Research Council of Italy / IRCCS Humanitas Research Hospital, Italy)
"Unlocking Cardiac Laminopathies: Insights and Future Perspectives From Pluripotent Stem Cell Models"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aging of Skeleton and Circulation
Discussion Leader: Dolores Pérez-Sala (CSIC, Spain)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Vicente Andres (Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain)
"Progerin-Induced Cardiovascular Disease and Premature Aging: Mechanisms and Therapies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Susan Michaelis (The Johns Hopkins University School of Medicine, United States)
"Role of Prelamin A Processing by ZMPSTE24 in Premature and Physiological Aging"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Susana Gonzalo (Saint Louis University, United States)
"Genomic Instability and Sterile Inflammation: A Vicious Cycle in Aging"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Karima Djabali (Technical University of Munich, Germany)
"Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Noam Zuela-Sopilniak (Cornell University, United States)
"Getting to the Heart of LMNA-related Dilated Cardiomyopathy: Identifying Early Disease Drivers through a Multi-Level Transcriptomics Approach"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Jason Choi (Thomas Jefferson University, United States)
"LMNA Cardiomyopathy Pathogenesis as a Two-Variable System Involving Nuclear Damage and Fibrosis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Kohta Ikegami (Cincinnati Children's Hospital Medical Center, United States)
"Repairing the Nuclear Envelope to Counter Lamin-Related Cardiomyopathy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Anne Bertrand (Inserm , France)
"Unexpected miRNA Maturation Defect in KI-LmnaK32del Mouse Limits the Benefit of our Gene Therapy Based on Allele-Specific shRNA Knock-Down of Mutant Lamin A/C"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Nervous System Disorders
Discussion Leader: Pascale Bomont (Inserm-CNRS, France)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Tracy Hagemann (University of Wisconsin, Madison, United States)
"GFAP Mutations, Astrocyte Stress, and Alexander Disease: There is a Pattern Here"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Natasha Snider (University of North Carolina at Chapel Hill, United States)
"Form Meets Function: Neuronal and Glial Mechanisms in Giant Axonal Neuropathy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Winnok De Vos (University of Antwerp, Belgium)
"Aging-Associated Lamin B1 Decline Compromises Neuronal Fitness by Inducing Endoplasmic Reticulum Stress"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:35 pm
Nuria Goya (Centro de Investigaciones Biológicas Margarita Salas, CSIC, Spain)
"Role of GFAP in Lipid Homeostasis"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Milos Pekny (University of Gothenburg, Sweden)
"Aberrant Neurodevelopment in Human iPS Cell-Derived Models of Alexander Disease"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Inside and Outside The Cell
Discussion Leader: John Eriksson (Åbo Akademi University, Finland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Paul Janmey (University of Pennsylvania, United States)
"Vimentin Leaves Home: Extracellular Vimentin’s Effect on Cell Adhesion and Motility"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Lukasz Suprewicz (Medical University of Bialystok, Poland)
"Extracellular Vimentin: A TLR4 Agonist Triggering Neutrophil Responses"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Pedro Salas (University of Miami Miller School of Medicine, United States)
"Hsp70 Bound to the IF Scaffold: Sink or Chaperoning Powerhouse?"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Tom Golde (Institut de Bioenginyeria de Catalunya, Spain)
"Keratin Bundle Transition as a Stress Adaptation Mechanism"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Yaming Jiu (Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, China)
"The Function of Highly Ordered Network of Vimentin Intermediate Filaments in Pathogen Infection"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Stephanie Portet (University of Manitoba, Canada)
"Investigation of Intracellular Transport of Intermediate Filaments"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Sarah Steiner (University of Michigan, United States)
"KRT9/K9 Regulates Mechanosensitive Signaling and Epidermal Homeostasis in Palmoplanta"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Giulia Sultana (Abo Akademi University, Finland)
"Vimentin Supports Directional Persistence in Wound Healing in a YAP-Dependent Manner"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Benjamin Nanes (University of Texas Southwestern Medical Center, United States)
"A Keratin Switch and Vimentin Shuttle Organize Kinase Signaling to Promote Epidermal Remodeling"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Skin, Gut, and Liver Diseases
Discussion Leader: Pierre Coulombe (University of Michigan Medical School, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Diana Toivola (Åbo Akademi University, Finland)
"Colonocyte Keratins in Proliferation, Inflammation and Tumor Suppression"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Ji-Yeon Shin (Columbia University, United States)
"Lamina-Associated Polypeptide 1 in Hepatic Lipid Metabolism and Neoplasia"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Florian Geisler (Institute of Molecular and Cellular Anatomy, RWTH, Aachen, Germany)
"Role of Intestinal Intermediate Filaments in the Microbial Stress Response of C. Elegans"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:35 pm
Yin Loon Lee (Agency for Science, Technology and Research, Singapore)
"Investigating the Role of Nuclear-Cytoskeleton Coupling in Liver Fibrosis"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure