Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Dynamics in Disorder
3:15 pm - 3:45 pm
"Bridging Scales: The Extreme Dynamics of Intrinsically Disordered Proteins"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
From Numbers to Mechanisms: Theory, Computation, and Single Molecule Views of Disordered Proteins
5:30 pm - 5:40 pm
"The Role of Disordered Regions in SARS CoV-2 Nucleocapsid Protein-RNA Fuzzy Complexes"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Chemically Driven Simulations of Enzymatic Phosphorylation in TDP-43 Condensates"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Achieving Predictive All-Atom Simulations of Disordered Proteins and Assemblies"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Mechanisms of Dynamic Charge Regulation of Intrinsically Disordered Proteins"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Histidine in Disordered Proteins Can Modulate Their Conformations, Even at Constant pH"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Differential Conformational Expansion of NUP98-HOXA9 Oncoprotein from Nanosized Assemblies to Macrophases"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Dissecting the Dynamic Binding Mechanism of a Small Molecule to the Disordered Activation Domain of Androgen Receptor"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Probing the Mechanism of Coupled Folding/Binding of Hif-1a CTAD to CBP Taz1 with 3-Color Single-Molecule FRET"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Disorder in Action: Assemblies, Condensates, and Biological Mechanisms
9:00 am - 9:10 am
"Designer Organelles Formed with Intrinsically Disordered Proteins for Transcriptome-Wide RNA Recording in Mammalian Cells"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"TDP-43 Aggregation can Arise Independently of Phase Separation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Mechanical Control of Tau Phase Separation Using Active Microtubule Networks"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Probing the Internal Environment of Biomolecular Condensates: A Solution-NMR Approach to Characterise Pore Size and Client Protein Biophysics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Investigating the Role of RNA in Dhh1 Biomolecular Condensates"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Sequence-Encoded Determinants Drive Distinct Aggregation Pathways and Fibril Structures in Henipavirus PNT1 Proteins"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Investigating Sequence Properties Contributing to the Mixing of Polymer Dense Phases"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"The Function of Protein Disordered Regions Is Encoded in Their Modular Architecture"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Integrative and Quantitative Scientific Approaches as Key Transferrable Skills for Diverse Career Trajectories
1:30 pm - 2:30 pm
Panel Discussion
Building Career Pathways Through Integrative and Quantitative Science
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes