Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Ion Movement Across Membranes
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Mechanisms of Inactivation in Potassium Channels"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"The Tale of the Sodium/Iodide Symporter (NIS): From Cloning to Structure to Engineering"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Trailblazer Spotlight: Deorphanizing GluDs- the Molecular and Structural Landscape of Delta-type Glutamate Receptor Ion Channel Activity"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Multi-Modal Sensory Transduction
9:00 am - 9:20 am
"The Thermal Dance of TRPM Channels"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Asymmetric Architecture and Assembly Principles of Human TRPC Heteromers"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"How Structural Disorder Shapes Regulatory Protein and Lipid Interactions with TRP Channels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"CALCIUM, PIP2, AND HEAT: How TRPM4 Mediates Cell Signaling in Physiology and Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Structural Principles Governing Activation and Modulation of the TRPML Family"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Origins of Species-Specific Differences in TRPV2 Activation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Functional and Structural Basis of a Hypermorphic TRPC3 Variant"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integrated Approaches to Study Ion Channel Structure, Function, and Pharmacology
7:30 pm - 7:50 pm
"Deep Learning Approaches to Predict Conformational Ensembles of Membrane Proteins"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Steering Structure Prediction to Investigate Mechanotransduction"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"New Insights into Somatosensory Ion Channels"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Tools for Modeling Ion Channels at Near Atomic Resolutions"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Channeling the Spike- Voltage-Gated Channels
9:00 am - 9:20 am
"Structural Mechanisms of HCN Channel Modulation by Small Molecules"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Functional Ion Channel Coupling in Synaptic Manodomains"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"β-Adrenergic Regulation of the Cardiac Sodium Channel NaV 1.5"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Ca2+ Channel Switching at the Photoreceptor Synapse"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Lipid-Dependent Gating in Ion Channels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"AM404 and Nonpsychoactive Cannabinoids Silence Nociceptors via Sodium Channels"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Conserved Outer Pore Lysine Tunes Potassium-Dependent Macroscopic Currents in Kv2.1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Insight into Regulatory Mechanisms of Ion Channels Gating
7:30 pm - 7:50 pm
"Cellular Black Holes: Multiscale Mechanisms of Connexin Channel Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Structural Basis of Isoform-Specific Properties in Type 2 IP₃ Receptors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Activation and Regulation of the TMEM16F Ca2+ -Activated Scramblase and Ion Channel"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Puromycin-Sensitive Aminopeptidase Moonlights as an Auxiliary Subunit of Volume-Regulated Anion Channels"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
When Force Meets Function
9:00 am - 9:20 am
"Mechanotransduction in Auditory Hair Cells, A Tale of Two Channels"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Piezo2 Tension Sensitivity and its Modulation by Alternative Splicing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Structure and Function of the Mechanosensitive OSCA/TMEM63 Channels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Protein-Protein Interactions in the Mammalian Hair Cell Mechanotransduction Complex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Visualization of Mechanosensitive Ion Channels Under Mimicked Force"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Channel Pathologies: Mechanistic Insights and New Directions for Therapeutic Interventions
7:30 pm - 7:50 pm
"Cys-Loop Receptor Structures from Tissue Reveal Assembly and Regulatory Principles"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Autoantibodies Against the Glycine Receptor: Multiple Sites of Action and Associated Disorders"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Gaining Insight into PIEZO2 Function from a Rare Disease Causing Variant"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Designer Modulators to Tune Voltage-Gated Calcium Channels in Cardiac Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Subtype-Selective Modulation and Rescue of Epilepsy-Associated HCN1 Mutant Channels"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Navigating the Landscape of Ligand-Gated Channels: Mechanisms and Modulation
9:00 am - 9:20 am
"Lipid Modulation of Glutamate Receptors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Insect Pentameric Ligand-Gated Ion Channels: Structures and Binder Design"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Agonist Efficiency: The Missing Link"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"NMDA Receptors: Mechanisms for Gating and Calcium Permeation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mapping the Conformational Landscape of the Muscle-Type nAChR"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Asymmetric Activation and Desensitization in Homopentameric pLGICs"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Ion Channel Dynamics Across Modalities: Mechanics, Voltage, and Beyond
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Trailblazer Spotlight: Uncovering New Roles for Sodium Channels in Somatosensation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:30 pm
"Into the Matrix: How Touch Happens at the Nerve-Skin Nano-Interface"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"Inactivation of the Sodium Channel"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure