Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Somatosensation and Nociception
Discussion Leader: Sudha Chakrapani (Case Western Reserve University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
David Julius (University of California, San Francisco, United States)
"Structural Insights into TRP Channel Regulation: Visualizing a Polymodal Signal Integrator"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ute Hellmich (Friedrich Schiller University Jena, Germany)
"Structural Dynamics of TRP Channel Intrinsically Disordered Regions"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Y. Lyna Luo (Western University of Health Sciences, United States)
"Mechano-Electrical Coupling in PIEZO Channels"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Processes at the Synaptic Cleft
Discussion Leader: Crina Nimigean (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Sudha Chakrapani (Case Western Reserve University, United States)
"Partial Agonism in 5-HT3A R"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Julia Bleier (University of California, Berkeley, United States)
"Conformational Basis of Subtype-Specific Allosteric Control of NMDA Receptor Gating"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Ryan Hibbs (University of California San Diego, United States)
"Developmental Switch in Acetylcholine Receptor Composition at the Neuromuscular Junction"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Eva Hellsberg (NIH, United States)
"Where Do All the Cations Go?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yeeun Son (Weill Cornell Graduate School and Memorial Sloan Kettering Cancer Center, United States)
"Structural Basis of Lipid Head Group Entry to the Kennedy Pathway by FLVCR1"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Hyung Ho Lee (Seoul National University, South Korea)
"Cryo-EM Structure of Human Class C Orphan GPCR GPR179"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Eric Gouaux (Vollum Institute / Howard Hughes Medical Institute Inc, United States)
"How Studies of Neurotransmitter Receptors from Native Tissue Informs Structure and Mechanism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Renae Ryan (University of Sydney, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Receptors and Transporters in Neurons
Discussion Leader: Volodymyr Korkhov (Paul Scherrer Institute / ETH Zurich, Switzerland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Brian Kobilka (Stanford University, United States)
"Structural Insights into the Dynamic Process of GPCR Activation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Aashish Manglik (University of California, San Francisco, United States)
"Seeing Scents to Understand our Sense of Smell"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Jesse Mobbs (Monash University, Australia)
"Structural Investigation of Allosteric Modulation of the Delta Opioid Receptor"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Renae Ryan (University of Sydney, Australia)
"Unique Mechanism of a Glutamate Transporter From Drosophila Melanogaster Informs Ion-Coupling Mechanisms in Human Glutamate Transporters"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Receptors and Transporters Involved in Metabolic Diseases
Discussion Leader: Ute Hellmich (Friedrich Schiller University Jena, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Denise Wootten (Monash Institute of Pharmaceutical Sciences, Monash University, Australia)
"Biased Agonism at the GLP-1 Receptor: From Structure to Animal Models of Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Jonathan Moore (Rectify Pharmaceuticals, United States)
"A Structural and Mechanistic Model for BSEP Dysfunction in Severe Cholestatic Disease"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Enrica Bordignon (University of Geneva, Switzerland)
"The pH-Induced Prepore-to-Pore Transition of a Tc Toxin Unveiled by an Integrative Biophysical Approach"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Julia Kowal (ETH Zurich, Switzerland)
"Cryo-EM Structure of Human Drug Transporters OATP1B1 and OATP1B3"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Seok-Yong Lee (Duke University School of Medicine, United States)
"Antiviral Drug Recognition and Elevator-Type Transport Motion of the Nucleoside Transporter SLC28A3"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Paul Young (The Rockefeller University, United States)
"Structural Basis for CFTR Inhibition by CFTRinh -172"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Arne Moeller (University of Osnabrück, Germany)
"Cryo-EM Analyses of ABC Transporter Under the Influence of Substrates, Ligands, and Lipids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Drug, Water and Lipid Transport
Discussion Leader: Xiaochun Li (University of Texas Southwestern Medical Center, United States)
7:30 pm - 7:50 pm
Chia-Hsueh Lee (St. Jude Children’s Research Hospital, United States)
"Mechanism of Human Sphingolipid S1P Transporter Spns2"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Meghna Gupta (Oregon Health & Science University (OHSU), United States)
"Structural Analysis of Human Aquaporin-4 with Neuromyelitis Optica (NMO) Patient Derived Pathogenic Autoantibodies"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Maria Falzone (Rockefeller University, United States)
"Regulation of PLCß Enzymes by G Proteins"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Chieh-Chin Li (Weill Cornell Medicine, United States)
"Mechanism of Lipid-Dependent Cold Sensitivity in a Cyclic Nucleotide-Modulated Ion Channel From Spirochaeta Thermophila "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Amer Alam (The Hormel Institute, University of Minnesota, United States)
"Conformational Landscape of Lipid Embedded Human ABCB1"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nutrient, Intracellular, and Ion Transport
Discussion Leader: Olga Boudker (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
David Drew (Stockholm University, Sweden)
"Voltage and Lipid Regulation of Na+/H+ Exchangers"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Zhou Chen (University of California, San Francisco, United States)
"Structure of an EMC Chaperone: CaV Complex Reveals an Ion Channel Assembly Intermediate and a Holdase Function for the EMC"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Ming Zhou (Baylor College of Medicine, United States)
"Mechanism of Fe2+ Transport and Regulation in Ferroportin"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Michael Hennig (leadXpro AG, Switzerland)
"Structure-Based Drug Discovery on Membrane Proteins"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Dirk Slotboom (University of Groningen, The Netherlands)
"Single Molecule Fluorescence to Monitor Mechanisms of Vitamin Uptake"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Yvonne Hellmich (Goethe University Frankfurt, Germany)
"Structural and Functional Investigation of the Compatible Solute Transporter EctI"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Lily Jan (University of California, San Francisco, United States)
"Cryo-EM Structures of Endogenous Kv1 Channels in Mouse Brain GABAergic Neurons"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Channels and Transporters in Pathogens and Mitochondria
Discussion Leader: Dirk Slotboom (University of Groningen, The Netherlands)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Simon Newstead (University of Oxford, United Kingdom)
"A Painful Experience with a Solute Carrier"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Yangang Pan (Weill Cornell Medicine, United States)
"The ATPase Cycle of the AAA-ATPase Protein Transporter Bcs1 is Highly Concerted"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Edmund Kunji (University of Cambridge, United Kingdom)
"Sequence Symmetry and Asymmetry in Transport Proteins"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Alessio Accardi (Weill Cornell Medicine, United States)
"Structural Basis of Lipid Scrambling"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Ion Transport and Signaling
Discussion Leader: Simon Scheuring (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Janice Robertson (Washington University, United States)
"Dimerization Mechanism of an Inverted-Topology Ion Channel in Membranes"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Louise Laursen (Aarhus University, Denmark)
"Sorting of NMDAR is Facilitated by SorCS1 and SorCS2 through C-Terminal Tail Interactions"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Cristina Paulino (University of Heidelberg, Germany)
"Think Like a Channel, Act Like a Transporter: Mechanistic Insights into the Sperm-Specific SL9C1 Gated by Voltage and cAMP"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Teresa Giraldez (Institute of Biomedical Technologies / University of La Laguna, Spain)
"The Functional Coupling Between NMDA Receptors and BK Channels is Altered in the Fragile-X Syndrome Mouse Model"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Vaithish Velazhahan (Stanford University, United States)
"Structure, Activation, and Oligomerization Mechanisms of G Protein-Coupled Receptors in Fungi"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Libin Ye (University of South Florida/Moffitt Cancer Research Center, United States)
"Conformational Dynamics and Function of an Intermediate GPCR-G Protein Complex"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hee-Jung Choi (Seoul National University, South Korea)
"Structural Elucidation of Odorant Binding and Activation in the Human OR52 Family"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late Breaking Topics
Discussion Leader: Inga Hänelt (Goethe University Frankfurt, Germany)
7:30 pm - 7:50 pm
Wojciech Kopec (Queen Mary University of London, United Kingdom)
"Direct Activation of the TASK-1 K2P Channel with ONO-RS-082"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Dimitrios Stamou (University of Copenhagen, Denmark)
"Direct Observation of GPCR Drug Intrinsic Efficacy at the Plasma Membrane of Live Cells"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
David Sauer (University of Oxford, United Kingdom)
"Structure and Function of the SIT1 Proline Transporter in Complex with the COVID-19 Receptor ACE2"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Melissa Irvine (University of Cambridge, United Kingdom)
"Generation of Thermostable, High Yield a3ß Glycine Receptor Chimeras for Raising Antibody Modulators with Analgesic Properties"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Juan Du (Van Andel Institute, United States)
"How Temperature Modulates Ligand Recognition and Channel Gating"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure