Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Somatosensation and Nociception
Discussion Leader: Vera Moiseenkova-Bell (University of Pennsylvania, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
David Julius (University of California, San Francisco, United States)
"Structural Insights Into TRP Channel Regulation: Visualizing a Polymodal Signal Integrator"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ute Hellmich (Friedrich Schiller University Jena, Germany)
"Structural Dynamics of TRP Channel Intrinsically Disordered Regions"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Late-Breaking Topic
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Processes at the Synaptic Cleft
Discussion Leader: Crina Nimigean (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Sudha Chakrapani (Case Western Reserve University, United States)
"Partial Agonism in 5-HT3A R"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Short Talk Selected from Poster Abstracts
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Ryan Hibbs (University of California San Diego, United States)
"Structure and Pharmacology of Pentameric Neurotransmitter Receptors"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, United States)
"Where Do All the Cations Go? Potassium and the Serotonin Transport Cycle"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Eric Gouaux (Vollum Institute/HHMI , United States)
"How We Hear"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Renae Ryan (University of Sydney, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
GPCRs and Transporters in Neurons
Discussion Leader: Volodymyr Korkhov (Paul Scherrer Institute / ETH Zurich, Switzerland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Brian Kobilka (Stanford University, United States)
"Structural Insights Into the Dynamic Process of GPCR Activation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Aashish Manglik (University of California, San Francisco, United States)
"Seeing Scents to Understand our Sense of Smell"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Renae Ryan (University of Sydney, Australia)
"Unique Mechanism of a Glutamate Transporter from Drosophila Melanogaster Informs Ion-Coupling Mechanisms in Human Glutamate Transporters"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Receptors and Transporters Involved in Metabolic Diseases
Discussion Leader: Eduardo Perozo (University of Chicago, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Denise Wootten (Monash Institute of Pharmaceutical Sciences, Monash University, Australia)
"Biased Agonism at the GLP-1 Receptor: From Structure to Animal Models of Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Short Talk Selected from Poster Abstracts
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Enrica Bordignon (University of Geneva, Switzerland)
"The pH-Induced Prepore-to-Pore Transition of a Tc Toxin Unveiled by an Integrative Biophysical Approach"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Amer Alam (The Hormel Institute, University of Minnesota, United States)
"Structural Insights into Lipid Translocation by Human ABCA7"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Seok-Yong Lee (Duke University School of Medicine, United States)
"Antiviral Drug Recognition and Elevator-Type Transport Motion of the Nucleoside Transporter SLC28A3"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Drug and Lipid Transport
Discussion Leader: Xiaochun Li (University of Texas Southwestern Medical Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Cristina Paulino (University of Heidelberg, Germany)
"Think Like a Channel, Act Like a Transporter: Mechanistic Insights Into the Sperm-Specific SL9C1 Gated by Voltage and cAMP"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Short Talk Selected from Poster Abstracts
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Christine Hrycyna (Purdue University, United States)
"Modulating ABC Transporters at the Blood-Brain Barrier"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Late-Breaking Topic
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nutrient and Intracellular Transport
Discussion Leader: Nicolas Reyes (National Center of Scientific Research, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
David Drew (Stockholm University, Sweden)
"Voltage and Lipid Regulation of Na+/H+ Exchangers"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Short Talk Selected from Poster Abstracts
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Simon Newstead (University of Oxford, United Kingdom)
"A Painful Experience With a Solute Carrier"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Nieng Yan (Shenzhen Medical Academy of Research and Translation / Tsinghua University, China)
"How Many Ways to Inactivate a Cav or Nav Channel?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Late-Breaking Topic
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Channels and Transporters in Pathogens and Mitochondria
Discussion Leader: Olga Boudker (Weill Cornell Medicine, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Dirk Slotboom (University of Groningen, The Netherlands)
"Single Molecule Fluorescence to Monitor Mechanisms of Vitamin Uptake"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Short Talk Selected from Poster Abstracts
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Edmund Kunji (University of Cambridge, United Kingdom)
"Sequence Symmetry and Asymmetry in Transport Proteins"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Alessio Accardi (Weill Cornell Medicine, United States)
"Structural Basis of Lipid Scrambling"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploring Lipid and Ion Transport Through Structural, Functional, Biophysical and Computational Techniques
Discussion Leader: Simon Scheuring (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Janice Robertson (Washington University, United States)
"Dimerization Mechanism of an Inverted-Topology Ion Channel in Membranes"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Short Talk Selected from Poster Abstracts
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Emad Tajkhorshid (University of Illinois, United States)
"Dynamics and Energetics of AE1 Transport Cycle and its Coupling to Carbonic Anhydrase in Red Blood Cells"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Late-Breaking Topic
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late Breaking Topics
Discussion Leader: Inga Hänelt (Goethe University Frankfurt, Germany)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Late-Breaking Topic
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Short Talk Selected from Poster Abstracts
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Late-Breaking Topic
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Late-Breaking Topic
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure