Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Design, Synthesis, and Pharmacology of Novel Ligands Targeting the Membrane Proteins
Discussion Leader: Nicolas Heyder (Nuvisan ICB, Germany)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Amy Newman (National Institute on Drug Abuse Intramural Research Program, NIH, United States)
"Designing D3 R-Selective Bitopic Molecules for the Treatment of Substance Use Disorders"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms and Ligand Modulation of Membrane Proteins
Discussion Leader: Makayla Freitas (Vollum Institute, OHSU, United States)
7:30 pm - 7:45 pm
Alexandra Houser (Oregon Health & Science University, United States)
"Cation Modulation of d ENaC"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Michael Dalton (University of Pittsburgh, United States)
"Structural Mechanisms for VMAT2 Inhibition by Tetrabenazine"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Matthew Howard (UCSF, United States)
"Towards a Residue-Level Understanding of Proton Activation of GPCRs Using Deep Mutational Scanning and Cryo-EM"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Florian Gabriel (European Molecular Biology Laboratory (EMBL), Germany)
"Structural Basis of Substrate Transport and Drug Recognition by the Human Thiamine Transporter SLC19A3"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Audrey Warren (Icahn School of Medicine at Mount Sinai, United States)
"Structural Contributions to G-Protein Subtype Selectivity at the Serotonin Receptor 5-HT1A"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Taehyun Park (Weill Cornell Medical College, United States)
"The Mechanism of PIP2 Modulation of Rod Cyclic Nucleotide-Gated (CNG) Channel"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Linking Membrane Protein Structure and Dynamics
Discussion Leader: Xin Zhang (Monash University, Australia)
9:00 am - 9:15 am
Romy Thomas (Rudolf-Boehm-Institute for Pharmacology and Toxicology, Leipzig University, Germany)
"Multiple Activation Steps of a G-Protein-Coupled Receptor Define Downstream Signalling Specificity"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Hendrik Harms (University of Copenhagen, Denmark)
"Functional Regulation of the NALCN Sodium Leak Channel Complex by G Proteins"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Theodore Nettleton (Monash DDB, Australia)
"Structures and Dynamics of PAC1 Receptor Splice Variants in Different States"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Naomi Latorraca (University of California, Berkeley, United States)
"Domain Coupling in Activation of a Group C GPCR"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Yining Jiang (Weill Cornell Medicine, United States)
"HS-AFM Single-Molecule Structural Biology Uncovers Basis of Transporter Wanderlust Kinetics"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Daniel Frey (University of Oxford, United Kingdom)
"Understanding the State-Dependent Dynamics of the KDEL Receptor Using 13C Solution NMR"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: The Voice of Early Career Researchers in Publishing
Discussion Leader: Katarina Nemec (St Jude Children's Research Hospital, United States)
1:30 pm - 2:30 pm
Panel Discussion
The Voice of Early Career Researchers in Publishing
Lesley Anson (Science Colab, United Kingdom)
Renae Ryan (University of Sydney, Australia)
Ute Hellmich (Friedrich Schiller University Jena, Germany)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes