Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Liquid Biopsy: An Evolving Field
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Clinical Utility of Liquid Biopsy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Phylogenetic ctDNA Profiling in Early-Stage NSCLC: A Lung TRACERx Experience"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Exosome Mediated Immune and Stromal Cell Plasticity in Pre-Metastatic Niche Formation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Isolation Technologies and Tailored Applications
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Phenotypic Liquid Biopsies"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Investigation of Dynamic Changes in CTC Heterogeneity in Lung Cancer to Predict Responses to Checkpoint Inhibitors and Targeted Therapies"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Advances in Plasma-Based Liquid Biopsy for Patient Monitoring"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Quantitative High-Sensitivity Multiplex Detection of Rare KRAS Mutations in Liquid Biopsy Samples Using Digital Droplet PCR"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"EFIRM-Liquid Biopsy: Noninvasive Ultrasensitive Detection of Oncogenic Mutations in Plasma and Saliva"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CTC Subtyping and Propagation to Explore Tumor Biology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Characterizing CTC Subsets to Combat Breast Cancer Brain Metastasis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Cultured Circulating Tumor Cells Recapitulate Breast Cancer Metastatic Tropism and Reveal Brain Metastasis Drivers"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Microfluidic Labyrinth for the Isolation, Characterization and Expansion of CTCs"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Circulating Tumor Cells Display Epithelial-to-Mesenchymal Transition, Loss of MHCI Expression, and Differential Cytokine Secretions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Clues in Blood and Lymphatics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"MicroRNA and CpG Analysis in Blood of Patients with Endocrine Tumors"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Epigenetic Traces in Blood"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Lymph from Melanoma Patients Is Enriched in Tumor-Derived Exosomes, Proteins, and miRNA and Reveals a Protein Signature that Distinguishes Degree of Metastatic Spread"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
"The Role of the Lymphatic System in Cancer Progression"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tools for Biological and Functional Analyses
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Functional Analyses of Circulating Tumor Cells in Cancer Patients"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"New Tools for Longitudinal CTC Studies in Mouse Models of Cancer"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Microfluidics for the Isolation and Analysis of Liquid Biopsy Markers: CTCs, EVs and cfDNA"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Investigating the Multimodal Relationship Between Cell-Free DNA and Circulating Tumor Cells in Metastatic Breast Cancer Patients"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Products and Tumor-Educated Products in Circulation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Development and Clinical Applications of Molecular Assays for CTCs and Paired ctDNA"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Tumor-Educated Platelets for the Detection of Cancer"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Nanoparticle Drones: 4G Technology to Track and Kill Circulating Tumor Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Expanding the Repertoire of Peripheral Coding and Non-Coding RNA Biomarkers for Brain Tumors"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Comprehensive Molecular Analysis of Exosomes and Circulating Tumour DNA in Breast Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tumor-Associated Extracellular Vesicles and Liquid Biopsy
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Tumor Cell Extracellular Vesicles as Breast Cancer Biomarkers"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Diagnosing Disease with Rare Circulating Exosomes: Finding Heterogeneous, Nanoscale Pins in a Nanoscale Haystack"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"CTCs and Extracellular Shed Vesicles in Cancer: Using Microdevices to Characterize the Effects of Drug Resistance"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Isolation of Exosomes by nano-DLD Lab-on-a-Chip Technology for Clinical Applications"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Incorporating Liquid Biopsy into Clinical Trials
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Circulating Tumor Cell Biomarkers for Response and Prediction: Enumeration and Phenogenomics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Molecular Characterization of Circulating Tumor Cells for Precision Cancer Medicine"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Liquid Biopsy for Drug Development in Oncology"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Exosomal Transcriptomic Signatures Tracks and Predicts Response to Checkpoint Blockade Immunotherapy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Utility of Circulating microRNA Profiles for the Detection and Localization of Cancers in the Early Stage"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integrating Technology and Applications in Liquid Biopsy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Persistent Technology Challenges for Liquid Biopsies: A Perspective from the NCI"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Exploring Tumor Heterogeneity Within Circulating Tumor Cells"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Liquid Biopsy in Breast Cancer: From Discovery to Clinical Utility"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure