Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Evolutionary Plasticity of the Lung in Response to Environmental Changes: Lessons We Can Learn for Pulmonary Medicine
7:40 pm - 8:10 pm
"Evolutionary Adaptions to Stress: Lessons from Animals in Extreme Environments"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Evolution, the Logic of Biology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Susceptibility of the Developing Lung to Environmental Injury"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells: Which Ones at Which Stage of Life and in Response to Disease?
9:00 am - 9:30 am
"Generation and Regeneration of the Lung"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Dissecting the Role of Notch Signaling in the Adult Airway"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
"Stem
Cell Approaches to Understanding Differentiation, Disease and Therapy
in the Lung"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
"Cellular Heterogeneity and Plasticity
in Lung Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Differentiation and Selection of Adult Alveolar Progenitor Cells"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Development of the Acinar Airspaces Visualized by High Resolution 3D-Lung Imaging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Layering Regulatory Networks
of Differentiation into a Blueprint
7:30 pm - 7:55 pm
"Multiplexed In Situ Hybridization for
Molecular Profiling of Single Cells in Intact Tissues"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"A Hierarchical Gene Regulatory Network Controlling SOX9 Epithelial Progenitors"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Transcriptional Programming of Respiratory Epithelia at Single Cell Level"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Early Lung Progenitor Cell Commitment Redefines Alveolar Epithelial Ontogeny"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Communication Systems
9:00 am - 9:30 am
"Control of the Progenitor Cell Pool
and Lineage Specification in the Airway Epithelium"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Mesenchymal Plasticity Governs the
Progression and Resolution of Lung Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 11:00 am
"Integrating Signaling Inputs to
Maintain Lung Epithelial Progenitor Fate in the Developing Human Lung"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"The Role of
Notch Signaling Pathway in the Aetiology and Pathogenesis of Idiopathic
Pulmonary Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Biology of Alveolar Formation: The Role of Secondary Crest Myofibroblasts"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Anatomically and Functionally Distinct Mesenchymal Lineages in Lung Homeostasis and Regeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Communication Systems
7:30 pm - 7:55 pm
"Cell-Matrix
Interactions that Determine Progression of Lung Fibrosis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"G
Protein Regulation of Pulmonary Mechanobiology and Fibrosis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Mechanical
Activation of Fibroblasts: Experimental Challenges and Translational
Opportunities"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Increased Extracellular Matrix Remodeling Promotes Urethane-Induced Lung Carcinomas and Metastases in Mice Exposed In Utero to Second-Hand Smoke"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Origin and Consequences of Cellular Stress
9:00 am - 9:20 am
"Mitochondrial
Dysfunction in Lung Fibrosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Defective
Autophagy and Lysosomal Stress in Lung Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dysfunction
of the Proteasome System in Lung Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Genetic Variation in RTEL1 in Pulmonary Fibrosis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Lung Injury Response in COPD/Emphysema"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Metabolic Reprogramming of Recruited Macrophages Promotes Repair of the Injured Alveolus"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulating Inflammation in the Lung
7:30 pm - 8:00 pm
"Pulmonary Circadian Clocks and Inflammation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"The Inflammasome and Developmental
Regulation of Lung Inflammation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Macrophage
Diversity in the Lungs of Mice and Humans"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"IL-33 Regulates Monocyte Differentiation and Impacts Epithelial Repair via ILC2 Activation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Rewards of Systems Biology in an Omics Age
9:00 am - 9:30 am
"Reconstructing Regulatory Networks
from Time Series Single Cell
Lung Development Data"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Diffusion-Based Representations for Revealing Progressions, Multi-Scale Clusters and Gene Interactions in Noisy Single Cell Data"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"LincRNA Regulation of Fibroblast Transcriptional Networks in Pulmonary Fibrosis"
11:00 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Single Cell Transcriptomics of the Airway Epithelium in Asthma and Health"
11:50 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Hyperoxia Exposure of Developing Lung Epithelium Promotes Activated Wnt Signaling in Underlying Mesenchyme"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Smaller, the Better: Reductionist Models of Lung Biology
7:30 pm - 7:55 pm
"Lung
Pathophysiology in Three Dimensions: Introducing Human ‘Small Airway-on-a-Chip’"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Alveolar
Epithelial-Macrophage Crosstalk in the Innate Immune Response to Infection"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Using
iPSCs to Model Human Lung Development and Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Emergence of Human-Specific Genes and CNV Disease Susceptibility"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure