Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Lymphatic Malformations
Discussion Leader: Nils Hansmeier (Charité, Universitaetsmedizin Berlin, Germany)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Lucas Potier (De Duve Institute, UCLouvain, Belgium)
"Loss-of-Function Mutations of the TIE1 Receptor Tyrosine Kinase Cause Late-Onset Primary Lymphedema"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Zuzanna Juskiewicz (University of Virginia, United States)
"Piezo2: Vegfr3 Signaling Axis Regulates Lymphangiogenesis"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Lymphangiogenesis in Development and Disease
Discussion Leader: Yanna Tian (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Mariona Graupera (Josep Carreras Leukaemia Research Institute, Spain)
"A New Mechanism Regulating Integrin a9 Expression"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Sanjay Sunil Kumar (University Hospital, Westfälische Wilhelms Universität, Muenster, Germany)
"Carboxypeptidase D is a Critical Factor for Processing VEGF-C and Enabling Lymphatic Development"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Pinji Lei (Massachusetts General Hospital, United States)
"Lymphatic Muscle Cells are Unique Muscle Cells that Undergo Aging Induced Plasticity"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Silke Kreher (Max Planck Institute for Heart and Lung Research, Germany)
"MATR3-Based Alternative Splicing is Indispensable for Lymphangiogenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Richa Banerjee (University of South Florida, United States)
"mTORC2 Regulates Lymphatic Valve Formation and Maintenance Through AKT Induced Inactivation of Nuclear Foxo1"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Hans Schoofs (Uppsala University, Sweden)
"New Insight Into Mechanisms of Fluid Drainage by Lymphatic Capillaries"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Assessing Lymphatic Function and Disease
Discussion Leader: Amanda Peluzzo (Lewis Katz School of Medicine, Temple University , United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Kui Cui (Boston Children's Hospital / Harvard Medical School, United States)
"Targeting Foxc2 to Inhibit Epsin Function in Lymphatic Vasculature Mitigates Obesity and Lymphedema"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
Diandra Mastrogiacomo (University of South Florida, United States)
"Activating KRAS Mutations in Lymphatic Malformations"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Ahana Majumder (South Dakota State University, United States)
"Deciphering the Mechanisms of Corneal Lymphatic Remodeling During Inflammation and Wound Recovery"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Ryan Brown (Peter MacCallum Cancer Centre, Australia)
"Lymphatic Vessel Regeneration in Zebrafish"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Simon Cleary (University of California, San Francisco, United States)
"Functional Studies of Intact Pulmonary Lymphatics Using Intravital Microscopy"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Soumiya Pal (University of Arkansas for Medical Sciences, United States)
"Mechanism of Lymphatic Contractile Dysfunction in Hypertension"
10:30 am - 10:35 am
Discussion
10:35 am - 10:45 am
Samantha Kraus (Cornell University, United States)
"A Human Initial Lymphatic Chip Reveals Distinct Mechanisms of Primary Lymphatic Valve Dysfunction in Acute and Chronic Inflammation"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Advice to Lymphatics Early and Middle Career Researchers: How to be Successful in the Lymphatics Research Field
Discussion Leader: Kangsan Roh (Massachusetts General Hospital / Harvard Medical School, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Advice to Lymphatics Early and Middle Career Researchers: How to be Successful in the Lymphatics Research Field
William Repicci (Lymphatic Education & Research Network, United States)
Ben Hogan (Peter MacCallum Cancer Centre, Australia)
Mariona Graupera (Josep Carreras Leukaemia Research Institute, Spain)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes