Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Endolysosomal Function in the Nervous System
Discussion Leader: Lois Weisman (University of Michigan, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Sandra Maday (Perelman School of Medicine at the University of Pennsylvania, United States)
"Lysosomal Pathways in Synaptic Signaling Between Neurons and Astrocytes"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Pietro De Camilli (Yale University, United States)
"Bridge-like Lipid Transport Proteins in the Endo-Lysosomal System"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Mark von Zastrow (University of California, San Francisco, United States)
"Role of the Endocytic Pathway in Sculpting GPCR Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosomal Physiology and Human Disease
Discussion Leader: Gillian Griffiths (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
Shawn Ferguson (Yale University School of Medicine, United States)
"Lysosome Adaptations That Confer Parkinson's Disease Risk"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Haoxing Xu (Liangzhu Laboratory & Zhejiang University , China)
"Proton Release Mechanisms in the Lysosome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Short Talk Selected from Poster Abstracts
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Monther Abu-Remaileh (Stanford University, United States)
"Intra-Lysosomal Lipid Metabolism: Builders, Degraders and Regulators"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tobias Walther (Sloan Kettering Institute, United States)
"Mechanisms of Lysosomal Degradation of Sphingolipids"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Mara Duncan (University of Michigan, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Trafficking
Discussion Leader: Elizabeth Conibear (University of British Columbia, Canada)
7:30 pm - 7:50 pm
Amra Saric (The Hospital for Sick Children, Canada)
"ER-Localized Sorting Nexins Support Lipid Droplet Growth at ER-Endolysosome-Lipid Droplet Contacts"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Christopher Burd (Yale School of Medicine, United States)
"Inter-Organelle Lipid Trafficking"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Joost Holthuis (Osnabrück University, Germany)
"Transblayer Lipid Dynamics and Signalling in Lysosomal Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Entering and Leaving the Cell: Insights from Pathogens
Discussion Leaders: Max Gutierrez (The Francis Crick Institute, United Kingdom) and Christophe Lamaze (Institut Curie, France)
9:00 am - 9:20 am
Rebecca Lamason (Massachusetts Institute of Technology, United States)
"Microbial Manipulation of Host Membranes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nihal Altan-Bonnet (National Institutes of Health, United States)
"Enhanced Viral Transmission through Autophagosomal and Lysosomal en bloc Egress"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Short Talk Selected from Poster Abstracts
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Maria João Amorim (Católica Biomedical Research Centre - Universidade Católica Portuguesa, Portugal)
"The Host Endocytic Recycling Pathway is Impaired During Influenza A Virus Infection to Form Liquid Organelles"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Arun Radhakrishnan (University of Texas Southwestern Medical Center, United States)
"Role of Membrane Cholesterol Accessibility in Host-Pathogen Interactions"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Lysosome, Autophagy, and Cellular Catabolism
Discussion Leader: James Hurley (UC Berkeley, United States)
7:30 pm - 7:50 pm
Oliver Florey (Babraham Institute, United Kingdom)
"The Role of Non-Canonical Autophagy as a Lysosome Stress Response"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Patricia Boya (University of Fribourg, Switzerland)
"Selective Autophagy Pathways During Organismal Aging"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosome Dysfunction and Neurodegeneration
Discussion Leader: Gilbert Di Paolo (Denali Therapeutics, United States)
9:00 am - 9:20 am
Aimee Kao (University of California, San Francisco, United States)
"Lysosomal Proteases and pH Regulation in Neurodegenerative Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Martin Kampmann (University of California, San Francisco, United States)
"Elucidating Endolysosomal Mechanisms in Neurodegeneration Using Unbiased CRISPR Screens"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Fenghua Hu (Cornell University, United States)
"Physiological and Pathological Functions of TMEM106B, a Lysosomal Membrane Protein Associated With Neurodegeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Alison Goate (Icahn School of Medicine at Mount Sinai, United States)
"Human Genetics Implicates Efferocytosis in Myeloid Cells as a Disease Risk Hub for Alzheimer's Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Technologies and Therapeutic Opportunities
Discussion Leader: Sandra Schmid (CZ Biohub San Francisco, United States)
7:30 pm - 7:50 pm
Jean-Philippe Pellois (Texas A&M University, United States)
"Late Endosomes as Cell Penetration Portals for the Cytosolic Delivery of Probes and Therapeutics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Tom Kirchhausen (Harvard Medical School, United States)
"Constitutive Endolysosomal Perforation in Neurons"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Late-Breaking Topic
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Late-Breaking Topic
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Endocytosis, Exocytosis and Intracellular Trafficking
Discussion Leader: Michael Marks (Children's Hospital of Philadelphia, United States)
9:00 am - 9:20 am
Melanie Ohi (University of Michigan, United States)
"From Blobs to Atoms and Back to Blobs: Using Cryo-EM to Understand the Structure of Caveolin"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Aurelien Roux (University of Geneva, Switzerland)
"In Vitro Dynamics of Membrane Remodelling by Archeal ESCRT-III"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rytis Prekeris (University of Colorado, United States)
"The Role of Rab40-Dependent Ubiquitylation in Regulating Endocytic Recycling and Activation of Rap GTPases During Cell Migration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Judith Klumperman (University Medical Center Utrecht, The Netherlands)
"The HOPS Complex: Integrating Lysosomal Trafficking Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Cedric Delevoye (INEM, INSERM, France)
"Cytoskeleton-Driven Spatialization of a Lysosome-Like Organelle Contributes to Genome Protection"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Protein-Lipid Interactions in Regulation of Cellular Membrane Dynamics
Discussion Leader: Scott Emr (Cornell University, United States)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:50 pm
Harald Stenmark (Oslo University Hospital, Norway)
"Converging Mechanisms of Lysosome Repair"
8:50 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure