Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Cellular Responses to Lysosomal Membrane Damage"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Lysosomal Quality Control in Health and Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Bridge-Like Lipid Transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Identifying Ubiquitin Ligases Driving Lysosomal Membrane Damage Response Processes"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"LASER Senses Lysosomal Damage and Initiates ESCRT Assembly for Membrane Repair"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endo Lysosomal Signaling, Sensing and Identity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"How do Lysosomes Shape Cell Identity? Using Synthetic Biology to Untangle the Role of Organelle Partitioning During Asymmetric Cell Division in Fate Specification"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Mechanisms of Lysosome Resilience: Shrinking Fast and Slow"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dynamic Regulation of Signaling Lipids on Endosomes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Noncatalytic Class II PI3-Kinase Variant Inhibits Endosomal Phosphoinositide Activity to Promote Autophagy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Role of Vacuolar Signaling Lipid Synthesis in Signaling Endosome Biogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Insight into TSC Protein Complex Function and Rheb Regulation in Lysosomal Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"LRRK2 Integrates Multiple Rab and GABARAP Interactions to Sense and Respond to Distinct Lysosomal Stresses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Endo Lysosomal Systems in Health and Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Novel Biomarkers of Endolysosomal Function in Health and Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Neurodegeneration Risk Variants Promote Lysosomal TMEM106B Fibril Accumulation"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Small Molecule Modulator of Autophagy Exerts Differential Effects on Maturation and Clearance of Soma and Axonal Lysosomes to Resolve Alzheimer’s Disease-Linked Pathologies in Human Neurons"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"The Michael J Fox Foundation Endolysosomal Biomarkers Portfolio: Advancing Drug Development Tools"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Defining Lysosomal Supercomplex Structures Across Scales"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Molecular Mechanisms of Membrane Remodeling, Cargo Sorting, and Lysosomal Regulation
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"BEACH Domain Proteins Function as Novel Cargo Sorting Adaptors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Coordination of ESCRT and Annexin Function During Membrane Repair"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Endosome Maturation Is Orchestrated by Inside-Out Proton Signaling Through a Na+/H+ Exchanger and pH-Dependent Rab GTPase Cycling"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Endosomal Trafficking of the Immune Checkpoint Receptor CTLA4"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Exploring the Function and Regulation of C. Elegans VPS-13, the Ortholog of Human VPS13A/VPS13C, Whose Mutations Result in Neurodegenerative Diseases"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Endosomal Sorting Protein VPS35 Has a Central Role in Systemic Cholesterol Homeostasis by Controlling Lysosomal Cholesterol Handling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Regulation of Lysosomal Vesicle Acidification Along the Axon via mRAVE-Dependent v-ATPase Assembly"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"New Modes of V-ATPase Activity Regulation in Neuronal Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organelle Interactions and Contact Sites
7:30 pm - 7:50 pm
"At the Crossroads: Membrane Contact Site Crosstalk in Cholesterol Homeostasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Endosome/ER Crosstalk During Autophagosome Biogenesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"PIKfyve Activity Influences Inter-Organelle Contacts With Lysosomes to Modulate Endoplasmic Reticulum Dynamics"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Cargo Movement at Endosome-Lipid Droplet Contact Sites"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mitophagy, Contact Sites and ERAD: Connecting the Dots"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Dynamics and Cellular Adaptations in Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Uncovering Lysosome Mediated Adaptative Mechanisms During Cancer Metastasis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Caveolae Mechanics in Cell Signaling and Communication: Role in Tumorigenesis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Endosomal Trafficking in Metabolic Control"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"New Ways to Make and Move Lysosomes: Lessons From Intracellular Pathogens"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"The Retrograde Transport Machinery as a Shared Vulnerability in Viral Infections"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Endosomal Membrane Dynamics and Organization in Primary Ciliogenesis Initiation and Progression in Normal and Disease States"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Being in the Right Place: How Sorting Defects of Immune Receptors can Cause Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Intravital pH Imaging of an Intact Mouse Brain Using the pH Sensor ApHID Reveals Inefficient Lysosomal Acidification in Microglia Versus Inflammation-Induced Acidification in Brain Macrophages"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Imaging and Quantitative Approaches Towards Endo Lysosomes
7:30 pm - 7:50 pm
"Intravital Microscopy to Investigate Actomyosin Regulation of Membrane Remodeling in Endo-Lysosome Biology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"splitFAST to Monitor and Drive Organelle Interactions"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Visualizing Lysosomal Pathogenesis in Mucolipidosis Type IV Using Cryo Electron Tomography"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Structural Diversity of Flat and Curved Clathrin Coats at the Plasma Membrane by Cryo-Electron Tomography"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Illuminating the Endolysosomal System in Neurodegenerative Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Specialized Organelles and Pathways
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"A Pigmented View of the Primary Cilium"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Lysosome-Related Organelle Transport: How Does Small GTPase Rab27a Rule Spire-Type Actin Nucleators to Disperse Melanosomes"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Molecular Mechanisms of Melanin Transfer and Processing in Skin Pigmentation"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"The Development of Super-Resolution CLEM to Study AP3 in Secretory Granule Formation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Switching MVB Fates Toward Lysosomal Fusion"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"TRANSFER: Programmable Macromolecule Delivery Through Engineered Trogocytosis and Endosomal Escape"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Imagining the Future of Cell Biology and Cell Biologists"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Lysosomes, Related Organelles and their Specific Functions
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 9:10 pm
"Lysosomal Curiosities: Armed with Granules, Primed for Destruction, and Hungry for Targets"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure