Conference Description
The human genome is constantly threatened by DNA damage and replication stress. In normal cells, a variety of DNA repair pathways are used to protect the genome against different types of DNA damage and replication stress. When these repair pathways go awry, genomic instability will arise, giving rise to diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will bring together diverse researchers studying the mechanisms that protect the human genome, and the implications of these mechanisms in human diseases and therapies. In addition, the conference will promote discussions on how to target defects in the DNA damage response in cancer therapy, and how to gain a better understanding of tumor evolution and therapeutic responses through genomic approaches.
A diverse cadre of invited speakers will present new discoveries, approaches, and concepts at the frontier of mammalian DNA repair. Additionally, multiple speakers will be selected from abstract submissions and vigorous poster sessions will provide opportunities for sharing participants' latest research. This GRC will continue a strong tradition of welcoming young scientists, connecting new and senior members of the field, and engaging all participants in discussion through an open atmosphere of scientific exchange.
Applications from investigators interested in all aspects of DNA metabolism and genome stability from basic mechanisms to clinical intervention are encouraged. Trainees are encouraged to attend this GRC and the associated GRS.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by June 30, 2021. Please check back for updates.
Keynote Session: Connecting DNA Repair with DNA Replication
Discussion Leaders
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Maria Jasin (Memorial Sloan Kettering Cancer Center, USA)
Speakers
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Karlene Cimprich (Stanford University School of Medicine, USA)
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Johannes Walter (Harvard Medical School, USA)
Repair of Chromosomal Breaks
Discussion Leaders
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Wei Yang (National Institutes of Health, USA)
Speakers
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Maria Jasin (Memorial Sloan Kettering Cancer Center, USA)
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Zhenkun Lou (Mayo Clinic, USA)
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Stephen West (Francis Crick Institute, United Kingdom)
Base Excision Repair
Discussion Leaders
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Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA)
Speakers
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Bret Freudenthal (University of Kansas Medical Center, USA)
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Yuan Liu (Florida International University, USA)
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Joann Sweasy (University of Arizona Cancer Center, USA)
DNA Replication and Replication Stress Response
Discussion Leaders
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Agata Smogorzewska (The Rockefeller University, USA)
Speakers
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David Cortez (Vanderbilt University School of Medicine, USA)
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Alessandro Vindigni (Washington University at St. Louis, USA)
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Wei Yang (National Institutes of Health, USA)
DNA Repair and Human Diseases
Discussion Leaders
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Junjie Chen (The University of Texas MD Anderson Cancer Center, USA)
Speakers
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Alan D'Andrea (Dana-Farber Cancer Institute, USA)
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Agata Smogorzewska (The Rockefeller University, USA)
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Shan Zha (Columbia University, USA)
Genetics and Genomics of DNA Repair
Discussion Leaders
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Shan Zha (Columbia University, USA)
Speakers
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Roger Greenberg (University of Pennsylvania, USA)
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Andre Nussenzweig (National Cancer Institute, NIH, USA)
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Gaelle Legube (University of Toulouse, France)
Targeting DNA Repair Pathways in Cancer Therapy
Discussion Leaders
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Roger Greenberg (University of Pennsylvania, USA)
Speakers
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Christopher Bakkenist (University of Pittsburgh, USA)
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Li Lan (Harvard Medical School, USA)
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Mark O'Connor (AstraZeneca, United Kingdom)
Telomere Maintenance and Genomic Instability
Discussion Leaders
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Agnel Sfeir (New York University, USA)
Speakers
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Titia de Lange (The Rockefeller University, USA)
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Roger Reddel (Children's Medical Research Institute, Australia)
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Jerry Shay (University of Texas Southwestern Medical Center, USA)
DNA Repair and Therapeutic Responses
Discussion Leaders
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Gaelle Legube (University of Toulouse, France)
Speakers
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Simon Boulton (The Francis Crick Institute, United Kingdom)
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Agnel Sfeir (New York University, USA)
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Junjie Chen (The University of Texas MD Anderson Cancer Center, USA)
