Conference Description
The Mammalian DNA Repair GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.
Exposures to environmental and endogenous DNA damaging agents produce thousands to over a million DNA lesions and chemical modifications to the genome per cell every day. Perturbations in the cellular pathways that respond to DNA damage are linked to myriad human diseases across nearly every cell and organ type. Conversely, dysfunction in DNA damage responses presents new vulnerabilities that are being leveraged to selectively target tumors in a more efficacious and less toxic manner. This GRC will bring together researchers at all levels including principal investigators, lead scientists, postdoctoral fellows and graduate students from academia, government and industry, to share and discuss the latest cutting-edge research on mechanisms of genome maintenance and roles in human health.
A diverse group of invited speakers will present new ideas, approaches, and discoveries at the forefront of DNA mammalian repair research. Additionally, several talks will be selected from the abstract submissions, and highly interactive poster sessions will provide opportunities for sharing and discussing research. This GRC will continue a strong tradition of inclusivity by welcoming young scientists, women, and underrepresented members of the scientific community in a format that engages all participants in discussion through an open and interactive atmosphere of scientific exchange.
Applications from scientists interested in all aspects of DNA metabolism and genome maintenance from fundamental mechanisms to clinical interventions are encouraged to apply. Trainees are encouraged to attend this GRC and the associated GRS.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by October 8, 2022. Please check back for updates.
Keynote Session: Frontiers in DNA Repair
Discussion Leaders
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Karlene Cimprich (Stanford University School of Medicine, United States)
Speakers
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Tanya Paull (University of Texas at Austin, United States)
Repair in Telomeres and Repetitive Sequences
Discussion Leaders
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Hilda Pickett (Children's Medical Research Institute, Australia)
Speakers
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Eros Lazzerini Denchi (National Cancer Institute, NIH, United States)
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Titia de Lange (The Rockefeller University, United States)
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Single Molecule Approaches in DNA Repair
Discussion Leaders
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Orlando Schärer (IBS Center for Genomic Integrity, South Korea)
Speakers
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Bennett Van Houten (University of Pittsburgh, United States)
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Eric Greene (Columbia University, United States)
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Wei Yang (National Institutes of Health, United States)
CRISPR and Chromosome Break Repair
Discussion Leaders
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Titia de Lange (The Rockefeller University, United States)
Speakers
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Alberto Ciccia (Columbia University Irving Medical Center, United States)
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Lee Zou (Harvard University, United States)
Replication Induced DNA Damage
Discussion Leaders
Speakers
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David Cortez (Vanderbilt University School of Medicine, United States)
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Sharon Cantor (University of Massachusetts Medical School, United States)
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Helle Ulrich (Institute of Molecular Biology (IMB) Mainz, Germany)
Advances in Excision Repair
Discussion Leaders
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Bret Freudenthal (University of Kansas Medical Center, United States)
Speakers
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Sheila David (University of California, Davis, United States)
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Guo-Min Li (Univ of Texas Southwestern Med Center, United States)
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Nima Mosammaparast (Washington University in St. Louis, United States)
DNA Damage, Repair and Immune Signaling
Discussion Leaders
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Alberto Ciccia (Columbia University Irving Medical Center, United States)
Speakers
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Joann Sweasy (University of Arizona Cancer Center, United States)
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Andrew Jackson (MRC Human Genetics Unit / Institute of Genetics and Cancer / University of Edinburgh, United Kingdom)
Targeting DNA Repair in Therapeutics
Discussion Leaders
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Lee Zou (Harvard University, United States)
Speakers
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Simon Boulton (The Francis Crick Institute, United Kingdom)
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Ralph Scully (Beth Israel Deaconess Medical Center/Harvard Medical School, United States)
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Michal Zimmermann (Repare Therapeutics Inc., Canada)
DNA Damage in Aging and Disease
Discussion Leaders
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Sharon Cantor (University of Massachusetts Medical School, United States)
Speakers
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Andre Nussenzweig (National Cancer Institute (NCI), National Institutes of Health (NIH), United States)
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Laura Niedernhofer (University of Minnesota, United States)
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Grant Stewart (University of Birmingham, United Kingdom)
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Keith Caldecott (University of Sussex, United Kingdom)
The GRC Power Hour™