Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Stem Cell Regulation and Development
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
"Getting Abreast of the Mammary Epithelial Hierarchy"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Regulation of Development and Disease
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Dynamic Architectural Interplay Between Immune Cells and Mammary Gland Epithelium"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"One Microenvironment Does Not Fit All: Immunosubtyping Breast Cancer for Better Immunotherapies"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"SEMA7A Promotes Immunosuppression Associated with Postpartum Mammary Gland Involution and Breast Cancer"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Macrophages Facilitate Angiogenesis in Mammary Tumors of Obese Mice"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Cytokine Regulation of Early Breast Cancer Progression"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epithelial Morphogenesis and Functional Differentiation
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Calcium Oscillations Control Lactation"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"NOTCHing up Milk Production by Harnessing Mammary Progenitor Cells"
8:50 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Powering Lactation by Taking out the Trash"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stromal Regulation of Epithelial Plasticity
Session in honor of Patricia Keely.
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Mechanisms by Which Stromal Architecture Regulates Carcinoma Progression"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Mucosal Biology and Tissue Involution Cooperate to Drive Breast Cancer Metastasis"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
"Mammographic Density and Circadian Clocks in Breast Cancer"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Dynamic Interactions Between the Extracellular Matrix and Estrogen Activity in Progression of ER+ Breast Cancer"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"The Mammary Force Landscape: An Assement of Mechanotransduction in Lactation and Involution"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Epigenetic Regulation
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Mammary Cytokine-Sensing Enhancer: Biology and Technology"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Decreased Expression of GLUT1 in NEU-Expressing Tumor Initiating Cells Causes Dramatic Changes in Stem Cell Biology"
8:50 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Novel Correlation-Based Network Analysis of Breast Tumor Metabolism Identifies the Glycerol Channel Protein Aquaporin-7 as a Regulator of Lipid and Arginine Metabolism During Breast Cancer"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcription and Translational Regulation of Development and Cancer
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Breast Tumor Heterogeneity: Act Locally, Think Globally"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"NELF Functions in Development and Tumorigenesis"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Single Cell Transcriptomic and Epigenetic Analyses of Mammary Development"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Targeting Lipid Pathways in Luminal Breast Cancer Stem Cells and Endocrine Resistance"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Sox9-Driven Lineage Plasticity Controls Basal-Like Breast Cancer Progression"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Breast Cancer and the Environment
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:10 pm
"Breaking the Obesity-Breast Cancer Link: New Targets and Strategies"
6:10 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
"Xenoestrogens and Breast Cancer Risk: A Balancing Act"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Prevention of Obesity-Associated Breast Cancer After Menopause: Two Interventions with Different Mechanisms"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Emerging Models of Mammary Development and Breast Cancer
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Humanizing the Mouse Mammary Gland to Study Hormone Action in Breast Carcinogenesis"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"A Mouse Model of Breast Cancer with Lymphatic Metastasis"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Patient-Derived Xenograft Organoids as Models of Therapy Response in Breast Cancer"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"PKA Signaling Shapes Tumor Evolution by Regulating Lineage Plasticity and Differentiation in Breast Cancer"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Lineage-Specific Function of IGF-1R in Wnt1-Mediated Mammary Tumorigenesis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Mammary Gland Research
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:45 pm
"Oncogene-Mediated Signal Transduction in Transgenic Models of Human Breast Cancer"
8:45 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure