Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Breast Stem Cell Biology
Discussion Leader: Senthil Muthuswamy (Beth Israel Deaconess Medical Center and Harvard Medical School, United States)
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7:40 pm - 7:55 pm |
Introduction by Discussion Leader
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7:55 pm - 8:55 pm |
Joan Brugge (Harvard Medical School, United States)
"High Resolution Mapping of Breast Epithelial Cell Populations"
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8:55 pm - 9:15 pm |
Discussion
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9:25 pm - 9:40 pm |
General Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Normal Breast Biology: Progenitor and Stem Cells
Discussion Leader: Renee Van Amerongen (University of Amsterdam, The Netherlands)
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9:00 am - 9:10 am |
Introduction by Discussion Leader
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9:10 am - 9:35 am |
Marja Mikkola (University of Helsinki, Finland)
"Building up the Mammary Gland: from Placode to First Branches"
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9:35 am - 9:50 am |
Discussion
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9:50 am - 10:15 am |
Elena Spina (Memorial Sloan Kettering Cancer Center, United States)
"Adhesion G Protein-Coupled Receptors in the Mammary Development and Breast Cancer"
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10:15 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:25 am |
Weston Porter (Texas A&M University, United States)
"MAMsplaining: Mitophagy and Mitochondria-ER Interactions in Mammary Gland Development"
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11:25 am - 11:40 am |
Discussion
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11:40 am - 11:55 am |
Gat Rauner (Tufts University School of Medicine, United States)
"Short Talk Selected from Poster Abstracts: Combining 3D Organoids and Genetic Technologies to Reveal Developmental Programs"
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11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:20 pm |
Fabio De Martino (Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Switzerland)
"Short Talk Selected from Poster Abstracts: Contraceptive Progestins Differ in Ability to Stimulate Proliferation of the Human Breast Epithelium"
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12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Leonie Young (Royal College of Surgeons in Ireland, Ireland) and Mohamed Bentires-Alj (University of Basel / University Hospital Basel, Switzerland)
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
Abnormal Breast Biology: Precancerous Lesions (DCIS)
Discussion Leader: Fariba Behbod (University of Kansas Medical Center, United States)
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6:00 pm - 6:10 pm |
Introduction by Discussion Leader
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6:10 pm - 6:35 pm |
Janet Jones (Barts Cancer Institute, United Kingdom)
"Microenvironmental Influences on DCIS Behaviour"
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6:35 pm - 6:50 pm |
Discussion
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6:50 pm - 7:15 pm |
Jelle Wesseling (Netherlands Cancer Institute, The Netherlands)
"Preventing Unnecessary Breast Cancer Treatment"
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7:15 pm - 7:30 pm |
Discussion
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7:30 pm - 7:45 pm |
Adetunji Toriola (Washington University School of Medicine, United States)
"Short Talk Selected from Poster Abstracts: RANKL Inhibition and Breast Tissue Gene Expression in High-Risk Premenopausal Women with Dense Breasts: A phase I Pilot Clinical Trial"
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7:45 pm - 7:55 pm |
Discussion
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7:55 pm - 8:00 pm |
General Discussion
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8:00 pm - 9:00 pm |
Dinner
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Heterogeneity in Breast Cancer
Discussion Leader: Walid Khaled (University of Cambridge, United Kingdom)
|
9:00 am - 9:10 am |
Introduction by Discussion Leader
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9:10 am - 9:35 am |
Rama Khokha (Princess Margaret Cancer Centre, Canada)
"Multiomics Approach to Identifying Lineage Vulnerabilities and Druggable Targets"
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9:35 am - 9:50 am |
Discussion
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9:50 am - 10:15 am |
Sean Egan (Hospital for Sick Children, Canada)
"Modeling Breast Cancer Progression in Mice - From Sleeping Beauty to Chromosome Engineering"
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10:15 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:25 am |
Helen Piwnica-Worms (The University of Texas MD Anderson Cancer Center, United States)
"Defining the Compositional, Spatial and Signaling Heterogeneity of Triple Negative Breast Cancer"
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11:25 am - 11:40 am |
Discussion
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11:40 am - 11:55 am |
Tarek Taifour (McGill University, Canada)
"Short Talk Selected from Poster Abstracts: Investigating the Role of the Secreted Cytokine Chitinase-3 Like Protein 1 in Immune Suppression and Breast Cancer Progression"
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11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:20 pm |
Nicolas Roth (Queen Mary University London, United Kingdom)
"Short Talk Selected from Poster Abstracts: Cannabinoid Receptor 2 Expression Leads to a Migratory Stem Cell Phenotype in HER2+ Breast Cancer"
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12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
Molecular Alterations During Pregnancy and Lactation
Discussion Leader: Russell Hovey (University of California, Davis, United States)
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6:00 pm - 6:10 pm |
Introduction by Discussion Leader
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6:10 pm - 6:35 pm |
Camila dos Santos (Cold Spring Harbor Laboratory, United States)
"Life modifiers of pregnancy-induced mammary gland development"
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6:35 pm - 6:50 pm |
Discussion
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6:50 pm - 7:15 pm |
Carles Lerin (Institut de Recerca Sant Joan de Déu, Spain)
"Breast Milk Composition: Focus on One-Carbon Metabolism"
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7:15 pm - 7:30 pm |
Discussion
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7:30 pm - 7:45 pm |
Alejandro Collado (Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Spain)
"Short talk selected from Poster Abstracts: Loss of Luminal Rank Signaling Leads to Basal Stem Cell Bipotency in Post Pregnancy Mammary Glands"
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7:45 pm - 7:55 pm |
Discussion
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7:55 pm - 8:00 pm |
General Discussion
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8:00 pm - 9:00 pm |
Dinner
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Residual Disease and Metastasis
Discussion Leader: Eva Gonzalez-Suarez (Centro Nacional de Investigaciones Oncológicas, Spain)
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9:00 am - 9:10 am |
Introduction by Discussion Leader
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9:10 am - 9:35 am |
Marianna Rapsomaniki (IBM Research, Switzerland)
"Artificial Intelligence and Single Cell Approaches to Unravel Tumor Heterogeneity"
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9:35 am - 9:50 am |
Discussion
|
9:50 am - 10:15 am |
Brian Booth (Clemson University, United States)
"Investigating the Mechanisms of HER2+ Breast Cancer Cell Redirection"
|
10:15 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:25 am |
Mohamed Bentires-Alj (University of Basel / University Hospital Basel, Switzerland)
"To Sleep or Not to Sleep: Tumor Dormancy and Immune Host Defense"
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11:25 am - 11:40 am |
Discussion
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11:40 am - 11:55 am |
Hartland Jackson (Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Canada)
"Short Talk Selected from Poster Abstracts: Multiplex Imaging of Breast Cancer Lymph Node Metastases Identifies Prognostic Single-Cell Populations Independent of Clinical Classifiers"
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11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:20 pm |
Shayan Nazari (National Institutes of Health, United States)
"Short Talk Selected from Poster Abstracts: Long Prehensile Protrusions Pull Cells Through the Basement Membrane During Breast Cancer Invasion"
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12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Hormone Receptor Signaling
Discussion Leaders: Carrie Shemanko (University of Calgary, Canada)
|
6:00 pm - 6:10 pm |
Introduction by Discussion Leader
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6:10 pm - 6:35 pm |
Cathrin Brisken (École Polytechnique Fédérale de Lausanne, Switzerland)
"Hormones in Control of ER+ Breast Cancer Development"
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6:35 pm - 6:50 pm |
Discussion
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6:50 pm - 7:15 pm |
Leonie Young (Royal College of Surgeons in Ireland, Ireland)
"Aberrant Epigenetic Events in ER+ Breast Cancer Metastasis: Releasing the Brake on Cancer Cell Plasticity"
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7:15 pm - 7:30 pm |
Discussion
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7:30 pm - 7:45 pm |
Bruno Simões (University of Manchester, United Kingdom, United Kingdom)
"Short Talk Selected from Poster Abstracts: Antagonizing Progesterone Signaling to Target Luminal Progenitor Cells and Prevent Breast Cancers"
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7:45 pm - 7:55 pm |
Discussion
|
7:55 pm - 8:00 pm |
General Discussion
|
8:00 pm - 9:00 pm |
Dinner
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Novel Approaches to Study Mammary Development and Disease
Discussion Leader: Gillian Farnie (University of Oxford, United Kingdom)
|
9:00 am - 9:10 am |
Introduction by Discussion Leader
|
9:10 am - 9:35 am |
Toni Celià-Terrassa (Fundacio IMIM (VAT number ESG60072253), Spain)
"Stem Cell Implications in Breast Cancer Immunity"
|
9:35 am - 9:50 am |
Discussion
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9:50 am - 10:15 am |
Joaquin Arribas ( Vall d'Hebron Institute of Oncology (VHIO), Spain)
"Safe Redirection of Cytotoxic Lymphocytes Against Breast Cancer Cells"
|
10:15 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:25 am |
Emilia Peuhu (University of Turku, Finland)
"Morphometric Analysis of Human Breast Tissue Using Light Sheet Microscopy"
|
11:25 am - 11:40 am |
Discussion
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11:40 am - 11:55 am |
Nomeda Girnius (Harvard Medical School, United States)
"Short Talk Selected from Poster Abstracts: Cilengitide Sensitivity is Dictated by Extracellular Matrix Profiles in Breast Cancer"
|
11:55 am - 12:05 pm |
Discussion
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12:05 pm - 12:20 pm |
Aditi Bapat (University of Minnesota, Minneapolis, MN, USA, United States)
"Short Talk Selected from Poster Abstracts: Contributions of NF-kB inTumor-Associated Macrophages Promoting Resistance to JAK Inhibition in Triple-Negative Breast Cancer"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Keynote Session: Translational Breast Cancer Research
Discussion Leaders: Robert Clarke (University of Manchester, United Kingdom)
|
6:00 pm - 6:15 pm |
Introduction by Discussion Leader
|
6:15 pm - 7:15 pm |
Raoul Coombes (Imperial College, United Kingdom)
"Translational Aspects of Detection and Treatment of Endocrine Resistant Patients with Breast Cancer: New Approaches"
|
7:15 pm - 7:35 pm |
Discussion
|
7:35 pm - 7:45 pm |
General Discussion
|
7:45 pm - 8:00 pm |
Closing Remarks
|
8:00 pm - 9:00 pm |
Dinner
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
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