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Sunday
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| 4:00 pm - 8:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Phytoplankton Chemical Cues and Toxins
Discussion Leader: William Fenical (Scripps Institution of Oceanography, USA)
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| 7:40 pm - 7:50 pm |
Opening Remarks
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| 7:50 pm - 8:20 pm |
Julia Kubanek (Georgia Institute of Technology, USA)
"Current Challenges in Marine Chemical Ecology Research: What Happens once Natural Products Leave the Organism that Made Them"
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| 8:20 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
David Hopp (National Institutes of Health, USA)
"NCCIH Program Priorities for Marine Natural Products – 2018"
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Kathi Lefebvre (Northwest Fisheries Science Center, NOAA, USA)
"A Synthesis of Exposure Risks and Health Effects of the Marine Neurotoxin Domoic Acid from Studies with Fish, Mice, Sea Lions, and Humans"
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| 9:20 pm - 9:30 pm |
Discussion
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Monday
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| 7:30 am - 8:30 am |
Breakfast
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| 8:30 am - 9:00 am |
Group Photo
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| 9:00 am - 12:30 pm |
"Omic" Methods in Natural Product Research
Discussion Leader: Brian Murphy (University of Illinois at Chicago, USA)
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| 9:00 am - 9:30 am |
Jorn Piel (Institute of Microbiology, ETH Zurich, Switzerland)
"Mining (Meta)genomes for New Peptide Modifications"
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| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Abraham Badu-Tawiah (The Ohio State University, USA)
"Preparative Mass Spectrometry: Novel Synthetic and Reaction Screening Approaches"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:05 am |
Nadja Cech (University of North Carolina at Greensboro, USA)
"Untargeted Metabolomics Integrated with Bioassay Data for Natural Products Dereplication"
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| 11:05 am - 11:10 am |
Discussion
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| 11:10 am - 11:25 am |
Nadine Ziemert (University of Tübingen, Germany)
"Computational Tools for Prioritizing Drug Discovery in Actinomycetes"
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| 11:25 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Jason Kwan (University of Wisconsin-Madison, USA)
"Exploring the Biosynthetic Potential of Complex Microbial Communities"
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| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:20 pm |
Roger Linington (Simon Fraser University, Canada)
"Employing Stable Isotope Labeling to Connect Gene Clusters and Their Cognate Products: A Systems Approach"
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| 12:20 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Lena Gerwick (University of California, San Diego, USA)
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Synthetic and Biosynthetic Advances in Natural Product Research
Discussion Leader: Bradley Moore (University of California, San Diego, USA)
|
| 7:30 pm - 7:40 pm |
Introduction by Discussion Leader
|
| 7:40 pm - 7:50 pm |
Bethany Okada (Princeton University, USA)
"Natural Product Discovery in Burkholderia thailandensis Through Cryptic Gene Cluster Activation"
|
| 7:50 pm - 7:55 pm |
Discussion
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| 7:55 pm - 8:05 pm |
Joseph Gerdt (Harvard Medical School, USA)
"Bacterial Signals Regulate Multicellularity and Mating in Animals' Closest Relative"
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| 8:05 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:40 pm |
Daniel Romo (Baylor University, USA)
"Bioactivity-Guided Retrosynthesis: Progressive SAR and Mode of Action Studies of Natural Products"
|
| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Anne Osbourn (John Innes Centre, United Kingdom)
"Finding Drugs in the Garden: Mining Plant Chemical Diversity"
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| 9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Identification and Pre-Clinical Development of Marine Natural Products
Discussion Leader: Amy Wright (Florida Atlantic University, USA)
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| 9:00 am - 9:30 am |
Shmuel Carmeli (Tel Aviv University, Israel)
"Biologically Active Metabolites from Marine Organisms and Their Associated Microorganisms"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Michele Prinsep (University of Waikato, New Zealand)
"Strategies for Studying Bioactive Marine Organisms"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:05 am |
Chambers Hughes (Scripps Institution of Oceanography, USA)
"Labeling Natural Products in Complex Extracts"
|
| 11:05 am - 11:10 am |
Discussion
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| 11:10 am - 11:25 am |
Roberto Berlinck (Universidade de São Paulo, Brazil)
"Where Are and How to Find the Novel and Bioactive Secondary Metabolites"
|
| 11:25 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Alfonso Mangoni (Università di Napoli Federico II, Italy)
"Quantum Mechanical Prediction of Chiroptical Properties as an Aid for Structure Elucidation of Natural Products"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:20 pm |
Raymond Andersen (University of British Columbia, Canada)
"A Chemical Genetics Approach to the Discovery of Marine Natural Product Drug Leads"
|
| 12:20 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Developing the Next Generation of Pharmaceuticals
Discussion Leader: Eduardo Esquenazi (Sirenas, USA)
|
| 7:30 pm - 8:00 pm |
Carmen Cuevas (PharmaMar, Spain)
"Anticancer Drugs of Marine Origin in Development"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Kevin Penn (Warp Drive Bio, USA)
"Harnessing Genomic Information to Identify Natural Products with Novel Mechanisms of Action"
|
| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Pei-Yuan Qian (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Mechanisms of Antibiotic Resistance Revealed by Global Genome Mining and Biosynthesis Gene Cluster Manipulation"
|
| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Esther Schmitt (Novartis Pharma AG, Switzerland)
"Anti-Infective Research and Development"
|
| 9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Mechanisms of Action and Molecular Targets
Discussion Leader: Leticia Costalotufo (University of Sao Paulo, Brazil)
|
| 9:00 am - 9:30 am |
James McKerrow (University of California, San Diego, USA)
"Marine Natural Products as a Source of New Drugs for Neglected Tropical Diseases"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Barry O'Keefe (National Cancer Institute, NIH, USA)
"The NCI Program for Natural Product Discovery"
|
| 10:10 am - 10:20 am |
Discussion
|
| 10:20 am - 10:50 am |
Coffee Break
|
| 10:50 am - 11:05 am |
Scott Lokey (University of California, Santa Cruz, USA)
"Lessons from Nature in Predicting and Controlling Cell Permeability in Cyclic Peptides"
|
| 11:05 am - 11:10 am |
Discussion
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| 11:10 am - 11:25 am |
Lesley-Ann Giddings (Middlebury College, USA)
"Secondary Metabolism in the Acid Mine Drainage Microbiome at Ely Copper Mine in Vershire, VT"
|
| 11:25 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Sandra Loesgen (Oregon State University, USA)
"Gene Activation Strategies in Marine Endophytic Fungi"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:20 pm |
Edmund Graziani (Pfizer, USA)
"Natural Product Payloads for the Next Generation of Antibody-Drug Conjugates in Clinical Trials"
|
| 12:20 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Chemical Mediated Interactions
Discussion Leader: Kerry McPhail (College of Pharmacy, Oregon State University, USA)
|
| 7:30 pm - 8:00 pm |
Valerie Paul (Smithsonian Institution, USA)
"New Directions in Chemical Ecology on Coral Reefs"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:25 pm |
Marcy Balunas (University of Connecticut, USA)
"Secondary Metabolite Modulation in Host-Symbiont-Pathogen Systems"
|
| 8:25 pm - 8:30 pm |
Discussion
|
| 8:30 pm - 8:45 pm |
Mohamed Donia (Princeton University, USA)
"Widespread Biosynthesis of Defense Chemicals by Obligate Symbionts of Marine Organisms"
|
| 8:45 pm - 8:50 pm |
Discussion
|
| 8:50 pm - 9:20 pm |
Paul Straight (Texas A&M University, USA)
"A Model System for Antibiotics and the Physiology of Bacterial Competitive Fitness"
|
| 9:20 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Methodological Advances in Natural Product Research
Discussion Leader: Roger Linington (Simon Fraser University, Canada)
|
| 9:00 am - 9:30 am |
William Metcalf (University of Illinois at Urbana-Champaign, USA)
"Lessons Learned from Mining 10,000 Actinobacterial Genomes for Phosphonic Acid Natural Products"
|
| 9:30 am - 9:40 am |
Discussion
|
| 9:40 am - 10:10 am |
Lixin Zhang (East China University of Science and Technology, China)
"Learn from Microbial Intelligence for Avermectin Overproduction"
|
| 10:10 am - 10:20 am |
Discussion
|
| 10:20 am - 10:50 am |
Coffee Break
|
| 10:50 am - 11:05 am |
Lone Gram (Technical University of Denmark, Denmark)
"Tropodithietic Acid Producing Roseobacter Group Bacteria as Probiotics in Marine Aquaculture"
|
| 11:05 am - 11:10 am |
Discussion
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| 11:10 am - 11:25 am |
Shaun McKinnie (Scripps Institution of Oceanography / University of California, San Diego, USA)
"Discovery of the Biosynthesis of Domoic Acid in Pseudo-Nitzschia Diatoms"
|
| 11:25 am - 11:30 am |
Discussion
|
| 11:30 am - 11:45 am |
Masaki Fujita (Hokkaido University, Japan)
"Mycale Sponges Inherit Cytotoxin Producers Through Vertical Microbial Transfer"
|
| 11:45 am - 11:50 am |
Discussion
|
| 11:50 am - 12:20 pm |
Tim Bugni (University of Wisconsin-Madison, USA)
"Interspecies Interactions Between Bacteria Mediate Transcriptional Activation of an Otherwise Silent Biosynthetic Gene Cluster"
|
| 12:20 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Keynote Session: Future Directions in Marine Natural Products Research
Discussion Leader: Kirk Gustafson (National Cancer Institute, NIH, USA)
|
| 7:30 pm - 7:40 pm |
Introduction by Discussion Leader
|
| 7:40 pm - 8:10 pm |
Marcel Jaspars (University of Aberdeen, United Kingdom)
"The PharmaSea Project – Key Results and Influence on International Policy"
|
| 8:10 pm - 8:20 pm |
Discussion
|
| 8:20 pm - 8:30 pm |
Introduction by Discussion Leader
|
| 8:30 pm - 9:15 pm |
William Gerwick (Scripps Institution of Oceanography / University of California, San Diego, USA)
"Development of Promising Antiparasitic Leads from Marine Cyanobacterial Lipopeptides"
|
| 9:15 pm - 9:30 pm |
Discussion
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am |
Departure
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