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Sunday
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| 2:00 pm - 9:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Developing Marine Natural Product Therapies
Discussion Leader: Edmund Graziani (Apertor Pharmaceuticals Inc., USA)
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| 7:40 pm - 7:50 pm |
Opening Remarks
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| 7:50 pm - 8:20 pm |
Kris White (Icahn School of Medicine at Mount Sinai, USA)
"Host-targeted Antiviral Development, Treating the Current Pandemic and Preparing for the Next"
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| 8:20 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Short Talk Selected from Poster Abstracts
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Andreas Maderna (Sutro Biopharma, Inc., USA)
"Marine Natural Products and Antibody Drug Conjugates: A Journey from the Ocean’s Deep to the Clinic"
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| 9:20 pm - 9:30 pm |
Discussion
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Monday
|
| 7:30 am - 8:30 am |
Breakfast
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| 8:30 am - 9:00 am |
Group Photo
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| 9:00 am - 12:30 pm |
Climate Change, Marine Toxins and Environmental Solutions
Discussion Leader: Marcel Jaspars (University of Aberdeen, United Kingdom)
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| 9:00 am - 9:30 am |
Taifo Mahmud (Oregon State University, USA)
"Development of Marine-derived Sunscreens and Their Role in Ocean Conservation"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Constanze Kuhlisch (Weizmann Institute of Science, Israel)
"The Ecological Roles of Brominated Indole Alkaloids within Coccolithophore Blooms"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Yuko Cho (Tohoku University, Japan)
"Solving the Mystery of Saxitoxin Biosynthesis in Dinoflagellates: Turn-over, Subcellular Localization and Regulation"
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| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Eva Sonnenschein (Technical University of Denmark, Denmark)
"Life on Plastic: Deciphering the Functions of Marine Microbes in the Plastisphere"
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| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
Neha Garg (Georgia Institute of Technology, USA)
"Metabolomics Approaches to Probe Probiotic Potential of Cultured Coral-associated Bacteria"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
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| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
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| 3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Marcy Balunas (University of Connecticut, USA) and Alanna Condren (University of Michigan, USA)
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| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Synthetic Biology for Natural Product Production and Engineering
Discussion Leader: Jaclyn Winter (University of Utah, USA)
|
| 7:30 pm - 8:00 pm |
Alessandra Eustaquio (University of Illinois Chicago, USA)
"Reverse Genetics and Synthetic Biology for Natural Product Discovery and Production"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Brandon Morinaka (National University of Singapore, Singapore)
"Posttranslational Cyclophane Formation in Bacteria"
|
| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Katharine Watts (California Polytechnic State University, USA)
"Pinpointing Building Blocks and Amino Acid Ligases in TLN-05220 Biosynthesis"
|
| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Paul Scesa (University of utah, USA)
"Terpenoid Biosynthesis in Octocorals"
|
| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:25 pm |
Immo Burkhardt (UCSD - Scripps Institution of Oceanography, USA)
"Biosynthetic Origin of Octocoral Terpenoids"
|
| 9:25 pm - 9:30 pm |
Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Super Resolution Imaging for Natural Product Mechanisms
Discussion Leader: Laura Sanchez (University of California at Santa Cruz, USA)
|
| 9:00 am - 9:30 am |
Edward Boyden (Massachusetts Institute of Technology, USA)
"Biomining New Tools For Analyzing and Controlling Complex Biological Systems"
|
| 9:30 am - 9:40 am |
Discussion
|
| 9:40 am - 10:10 am |
Lu Wei (California Institute of Technology, USA)
"Mapping Biological Processes Through Molecular Vibrations"
|
| 10:10 am - 10:20 am |
Discussion
|
| 10:20 am - 10:50 am |
Coffee Break
|
| 10:50 am - 11:20 am |
Ville Paavilainen (University of Helsinki, Finland)
"Molecular Basis for Substrate-selective Inhibition of Protein Secretion"
|
| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Alia Alia (Matysik) (Leipzig University, Germany and Leiden University, The Netherlands)
"High Resolution MAS NMR Methods for Metabolic Profiling of Intact Zebrafish Embryos Exposed to Harmful Algal Bloom Toxins"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:20 pm |
Manuel Liebeke (Max Planck Institute for Marine Microbiology, Germany)
"Taking a Microscale Look at Symbiotic Interactions: New Metabolites from the Host–Microbe Interface"
|
| 12:20 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Synthetic Strategies for Natural Product Lead Development
Discussion Leader: Tadeusz Molinski (University of California, San Diego, USA)
|
| 7:30 pm - 8:00 pm |
Leslie Aldrich (University of Illinois at Chicago, USA)
"Building Biological Performance Diversity and Chasing Challenging Targets for Probe and Drug Discovery"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:25 pm |
Eduardo Caro-Diaz (University of Puerto Rico - Medical Sciences Campus, Puerto Rico)
"Walking the Non-biogenic Path: Cyanobacterial Pseudo-natural Products"
|
| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Yaoqiu Zhu (The University of Texas at El Paso, USA)
"Bioinspired 3D Printing of Complex Marine Natural Scaffold for Anticancer Lead Discovery"
|
| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Sarah Reisman (California Institute of Technology, USA)
"A Chemical Synthesis of Ritterazine B, A Marine Natural Product with Potent Anticancer Activity"
|
| 9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Computational Workflows for Natural Products Discovery
Discussion Leader: Roberto Berlinck (Universidade de São Paulo, Brazil)
|
| 9:00 am - 9:30 am |
Laura-Isobel McCall (University of Oklahoma, USA)
"Spatial Mass Spectrometry and Data Analysis Approaches for Rational Drug Development"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Roger Linington (Simon Fraser University, Canada)
"NP-Suite: New Tools to Process, Integrate and Annotate Mass Spectrometry and Bioactivity Data for Natural Products"
|
| 10:10 am - 10:20 am |
Discussion
|
| 10:20 am - 10:50 am |
Coffee Break
|
| 10:50 am - 11:20 am |
Hosein Mohimani (Carnegie Mellon University, USA)
"Machine Learning Methods for Discovering Natural Products from Large Mass Spectral Datasets"
|
| 11:20 am - 11:30 am |
Discussion
|
| 11:30 am - 11:45 am |
Allison Walker (Vanderbilt University, USA)
"Predicting Natural Product Activities with Machine Learning"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
Donovon Adpressa (Loxo Oncology at Lilly, USA)
"Conformational Analysis of Flexible Natural Products Based on Sparse Experimental Restraints"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Mehdi Beniddir (Universite Paris-Saclay, France)
"Digging Through the Data: Pursuing the Ideal Natural Product Discovery Scenario"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Lead Discovery, Molecular Targets and Phenotypic Screening
Discussion Leader: Daniela Trivella (National Center for Research in Energy and Materials (CNPEM), Brazil)
|
| 7:30 pm - 8:00 pm |
Eric Schmidt (University of Utah, USA)
"Ecology-driven Approaches to Biosynthesis and Drug Lead Discovery"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:25 pm |
Marsha Pierce (Midwestern University, USA)
"Preclinical Evaluation of Marine Natural Products for Neuroscience Drug Development"
|
| 8:25 pm - 8:30 pm |
Discussion
|
| 8:30 pm - 8:45 pm |
Ashootosh Tripathi (University of Michigan, USA)
"A Mass Spectrometry-based High-throughput Platform for Natural Product Electrophile Discovery and Biological Screening"
|
| 8:45 pm - 8:50 pm |
Discussion
|
| 8:50 pm - 9:20 pm |
Trever Smith II (Tufts University, USA)
"Classifying Drugs Using Morphological Changes in Treated Tubercle Bacilli"
|
| 9:20 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am - 12:30 pm |
Natural Products in the Context of Microbiomes and Symbioses
Discussion Leader: Shigeki Matsunaga (The University of Tokyo, Japan)
|
| 9:00 am - 9:30 am |
Margo Haygood (University of Utah, USA)
"The Role of Symbioses in Natural Product Discovery: Discoveries from Bacterial Symbionts of Shipworms"
|
| 9:30 am - 9:40 am |
Discussion
|
| 9:40 am - 9:55 am |
Emilia Sogin (University of California at Merced, USA)
"Sugars Dominate the Seagrass Rhizosphere"
|
| 9:55 am - 10:00 am |
Discussion
|
| 10:00 am - 10:15 am |
Robin Teufel (University of Basel, Switzerland)
"The Biosynthesis of Bacterial Tropone Natural Products Important for Marine Symbiotic Interactions Depends on a Novel Flavoprotein Dioxygenase Prototype"
|
| 10:15 am - 10:20 am |
Discussion
|
| 10:20 am - 10:50 am |
Coffee Break
|
| 10:50 am - 11:20 am |
Mohamed Donia (Princeton University, USA)
"Small Molecule-mediated Interactions in Symbiotic Systems"
|
| 11:20 am - 11:30 am |
Discussion
|
| 11:30 am - 11:45 am |
Emily Mevers (Virginia Polytechnic Institute and State University, USA)
"Chemical Investigations into the Microbiota of Marine Egg Masses"
|
| 11:45 am - 11:50 am |
Discussion
|
| 11:50 am - 12:20 pm |
Marcy Balunas (University of Connecticut, USA)
"Regulation of Specialized Metabolite Production in Complex Microbiome Systems"
|
| 12:20 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Keynote Session: Integrated Strategies for Marine Natural Products Discovery
Discussion Leader: Hendrik Luesch (University of Florida, USA)
|
| 7:30 pm - 7:40 pm |
Introduction by Discussion Leader
|
| 7:40 pm - 8:05 pm |
Julia Kubanek (Georgia Institute of Technology, USA)
"Integrating Metabolomics into Mechanism of Action Studies of Marine Natural Products"
|
| 8:05 pm - 8:15 pm |
Discussion
|
| 8:15 pm - 9:00 pm |
Phillip Crews (UC Santa Cruz, USA)
"Challenges and Adventures During Sponge Natural Products Chemistry Discovery at UCSC: The Good, The Bad, and The Ugly"
|
| 9:00 pm - 9:15 pm |
Discussion
|
| 9:15 pm - 9:30 pm |
General Discussion
|
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am |
Departure
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