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Marine Natural Products

Gordon Research Conference

Environmental Roles, Biological Targets and Applications

March 6 - 11, 2022

Chair

Vice Chair

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The 2022 Gordon Research Conference on Marine Natural Products will welcome diverse researchers at all career stages from academia, government and industry to share contemporary research addressing the environmental roles, biological targets and applications of marine natural products. The targets and applications of natural products critically depend on elucidation, biosynthesis and evolution of molecular structure, and investigation of function either in the environment or in translation to broad human health and well-being applications. Presentations and discussions will address these themes from multiple perspectives at the levels of molecules, cells, organisms and biomes. A Gordon Research Seminar preceding the Conference will again pave the way for early career scientists to network and build expertise in oral and poster presentations, before engaging with collegial research leaders across a multitude of scientific disciplines. Natural products research is a highly interdisciplinary field that is being accelerated by multi-disciplinary collaborations to address the central methodological and technical hurdles impeding translation of chemically and biologically complex natural products to applications for human health and well-being. Dynamic discussions in a range of formal and informal settings will catalyze new, cross-disciplinary research directions in marine natural products science.

Related Meeting

This GRC will be held in conjunction with the "Marine Natural Products" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Developing Marine Natural Product Therapies Discussion Leader:
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:20 pm	"Host-targeted Antiviral Development, Treating the Current Pandemic and Preparing for the Next"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Thioesterase-Mediated O-Acetylation and Double Bond Formation in Peloruside Biosynthesis"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Marine Natural Products and Antibody Drug Conjugates: A Journey from the Ocean’s Deep to the Clinic"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Climate Change, Marine Toxins and Environmental Solutions Discussion Leader:
9:00 am - 9:30 am	"Development of Marine-derived Sunscreens and Their Role in Ocean Conservation"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"The Ecological Roles of Brominated Indole Alkaloids within Coccolithophore Blooms"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Solving the Mystery of Saxitoxin Biosynthesis in Dinoflagellates: Turn-over, Subcellular Localization and Regulation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Life on Plastic: Deciphering the Functions of Marine Microbes in the Plastisphere"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Metabolomics Approaches to Probe Probiotic Potential of Cultured Coral-associated Bacteria"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Metabolomic Insights into Parasite Diseases of Phytoplankton"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Synthetic Biology for Natural Product Production and Engineering Discussion Leader:
7:30 pm - 8:00 pm	"Reverse Genetics and Synthetic Biology for Natural Product Discovery and Production"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Posttranslational Cyclophane Formation in Bacteria"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Pinpointing Building Blocks and Amino Acid Ligases in TLN-05220 Biosynthesis"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Terpenoid Biosynthesis in Octocorals"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Biosynthetic Origin of Octocoral Terpenoids"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Super Resolution Imaging for Natural Product Mechanisms Discussion Leader:
9:00 am - 9:30 am	"Biomining New Tools For Analyzing and Controlling Complex Biological Systems"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Mapping Biological Processes Through Molecular Vibrations"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Molecular Basis for Substrate-selective Inhibition of Protein Secretion"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"High Resolution MAS NMR Methods for Metabolic Profiling of Intact Zebrafish Embryos Exposed to Harmful Algal Bloom Toxins"
11:45 am - 11:50 am	Discussion
11:50 am - 12:20 pm	"Taking a Microscale Look at Symbiotic Interactions: New Metabolites from the Host–Microbe Interface"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Synthetic Strategies for Natural Product Lead Development Discussion Leader:
7:30 pm - 8:00 pm	"Building Biological Performance Diversity and Chasing Challenging Targets for Probe and Drug Discovery"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Walking the Non-biogenic Path: Cyanobacterial Pseudo-natural Products"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Bioinspired 3D Printing of Complex Marine Natural Scaffold for Anticancer Lead Discovery"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"A Chemical Synthesis of Ritterazine B, A Marine Natural Product with Potent Anticancer Activity"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Computational Workflows for Natural Products Discovery Discussion Leader:
9:00 am - 9:30 am	"Spatial Mass Spectrometry and Data Analysis Approaches for Rational Drug Development"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"NP-Suite: New Tools to Process, Integrate and Annotate Mass Spectrometry and Bioactivity Data for Natural Products"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Machine Learning Methods for Discovering Natural Products from Large Mass Spectral Datasets"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Predicting Natural Product Activities with Machine Learning"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Conformational Analysis of Flexible Natural Products Based on Sparse Experimental Restraints"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Digging Through the Data: Pursuing the Ideal Natural Product Discovery Scenario"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Lead Discovery, Molecular Targets and Phenotypic Screening Discussion Leader:
7:30 pm - 8:00 pm	"Ecology-driven Approaches to Biosynthesis and Drug Lead Discovery"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Preclinical Evaluation of Marine Natural Products for Neuroscience Drug Development"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"A Mass Spectrometry-based High-throughput Platform for Natural Product Electrophile Discovery and Biological Screening"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Classifying Drugs Using Morphological Changes in Treated Tubercle Bacilli"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Natural Products in the Context of Microbiomes and Symbioses Discussion Leader:
9:00 am - 9:30 am	"The Role of Symbioses in Natural Product Discovery: Discoveries from Bacterial Symbionts of Shipworms"
9:30 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Sugars Dominate the Seagrass Rhizosphere"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"The Biosynthesis of Bacterial Tropone Natural Products Important for Marine Symbiotic Interactions Depends on a Novel Flavoprotein Dioxygenase Prototype"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Small Molecule-mediated Interactions in Symbiotic Systems"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Chemical Investigations into the Microbiota of Marine Egg Masses"
11:45 am - 11:50 am	Discussion
11:50 am - 12:20 pm	"Regulation of Specialized Metabolite Production in Complex Microbiome Systems"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Integrated Strategies for Marine Natural Products Discovery Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Integrating Metabolomics into Mechanism of Action Studies of Marine Natural Products"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 9:00 pm	"Challenges and Adventures During Sponge Natural Products Chemistry Discovery at UCSC: The Good, The Bad, and The Ugly"
9:00 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

University of Michigan - Natural Product Discovery Core (NPDC)

Research reported in this publication was supported by the National Center For Complementary & Integrative Health of the National Institutes of Health under Award Number R13AT011840. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Marine Natural Products (GRS)

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