Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Enabling Technologies and Data Platforms for MNP Research
Discussion Leader: Marcel Jaspars (University of Aberdeen, United Kingdom)
7:40 pm - 8:00 pm
Justin J.J. van der Hooft (Wageningen University & Research, The Netherlands)
"Computational Metabolomics and Multi-Omics Tools and Approaches for Natural Product Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Shantanu Singh (Broad Institute of MIT and Harvard, United States)
"Accelerating Drug Discovery Using Machine Learning and Cell Painting Images"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Eunyong Park (University of California, Berkeley, United States)
"Elucidating the Mechanism of Sec61 Inhibitors by Cryo-Electron Microscopy"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Craig Butts (University of Bristol, United Kingdom)
"New Structures for Old(ish) Natural Products: Boldly Identifying 3D Structure (with NMR) Where None Were Identified Before"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
John Cort (Pacific Northwest National Laboratory & Washington State University, United States)
"The Natural Products Magnetic Resonance Database (NP-MRD): Enabling Resource for Natural Products Research"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genomics-Driven Discovery
Discussion Leader: Melanie Higgins (University of Alabama, United States)
9:00 am - 9:20 am
Jörn Piel (ETH Zurich, Switzerland)
"Natural Products from Strange Microbes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Wenjun Zhang (University of California Berkeley, United States)
"Enzymatic Synthesis of Bioactive Marine Natural Products"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Nadine Ziemert (University of Tübingen, Germany)
"Paleomycin - Resurrecting Ancient Glycopeptide Antibiotics"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Elizabeth Parkinson (Purdue University, United States)
"Utilizing Biocatalysis and Synthetic Chemistry to Access New Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Laura Ióca (Princeton University, United States)
"Evolution of Defensive Toxins Produced by an Algal Endosymbiont"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Bradley Moore (University of California, San Diego, United States)
"Biosynthesis of a Giant Ladder-Frame Polyketide by Toxic Microalgae"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Aya Yoshimura (Hokkaido University, Japan)
"Unlocking Silent Secondary Metabolites with Membrane Vesicle Mediated Interbacterial Communication"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sandra Loesgen (University of Florida, the Whitney Lab, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Biology for Natural Product Production
Discussion Leader: Amy Lane (University of North Florida, United States)
7:30 pm - 7:50 pm
Yousong Ding (University of Florida, United States)
"Integrative Genome and Synthetic Biology Approaches for the Discovery and Production of Marine Natural Products"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Helge Bode (Max Planck Institute for Terrestrial Microbiology, Germany)
"Engineering of Peptide and Peptide/Polyketide Pathways in High-Throughput"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Yanran Li (University of California San Diego, United States)
"Harnessing Microbial Cell Factories to Uncover Strigolactones of Essential Biological Functions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Benjamin Philmus (Oregon State University, United States)
"Taming the Green: Explorations in Synthetic Biology, Natural Products and Biochemistry in Cyanobacteria"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Leah Bushin (Scripps Institution of Oceanography - University of California San Diego, United States)
"Growth-Coupled Microbial Production of a Cephalopod Pigment"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis-Driven Discovery, Development and Advanced Conjugation Technologies
Discussion Leader: Daniel Romo (Baylor University, United States)
9:00 am - 9:20 am
Varinder Aggarwal (Bristol University, United Kingdom)
"Synthesis and Structure Determination of Natural Products"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tao Ye (Peking University Shenzhen Graduate School, China)
"Synergy of Prediction Rule and Synthesis in Solving the Stereochemical Puzzle of Natural Products"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jose Vergara Panzone (Yale University, United States)
"Rationally Designed Induced Proximity: Imitating Nature to Engineer Emergence in Small Molecules"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Alejandro Mayer (Midwestern University, College of Graduate Studies, Pharmacology Department, United States)
"Marine-Derived Pharmaceuticals in Clinical Trials in 2023"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Frank Fang (Eisai, United States)
"Discovery & Development of the First Chromium-Free Synthesis of Eribulin"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Damian O'Connell (Experimental Drug Development Centre, Singapore, Singapore)
"Preclinical Development and Phase I Initiation of a Singaporean ADC (EBT-129) with an MMAE Payload Derived from Dolastatin 10"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Marine Natural Products in Environmental Context: Chemical Ecology and Symbiosis
Discussion Leader: Valerie Paul (Smithsonian Institution, United States)
7:30 pm - 7:50 pm
Georg Pohnert (FSU Jena, Germany)
"Aging, Rejuvenation and Adaptation of Unicellular Algae within the Plankton Microbiome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Christine Beemelmanns (Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Germany)
"Symbiosis-Driven Natural Product Discovery Approaches: From Morphogenic Cues to Protective Agents"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Peter Schupp (Institute of Chemistry and Biology of the marine Environment, University of Oldenburg, Germany)
"Marine Natural Products to the Rescue: The Search for Coral Larvae Settlement Cues for Coral Restoration"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Dulce Guillen (University of Michigan, United States)
"Connecting the Dots: The Metabolome, Microbiome and Metallome of Botryllus schlosseri "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Vinayak Agarwal (Georgia Institute of Technology, United States)
"Opportunities and Challenges in Engineering Marine Peptidic Natural Products"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Integrated Approaches to Structure and Function
Discussion Leader: Matthias Koeck (Alfred-Wegener-Institut, Germany)
9:00 am - 9:20 am
Pei-Yuan Qian (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Diverse Compounds with Similar Backbone Structures Produced by a Bacterial Strain Showing Excellent Antiviral, Antibacterial and Neuroprotective Bioactivities"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Margherita Sosio (Naicons Srl, Italy)
"Micro4all: A Major Change in Drug Discovery"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Robert Capon (The University of Queenland, Australia)
"Harvesting Molecular Diversity from Fish Gut Fungi"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Katherine Duncan (University of Strathclyde, United Kingdom)
"Unchartered Waters: Linking Genes to Molecules in the High Seas"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mark Hamann (Medical University of South Carolina, United States)
"The Surprising Therapeutic Potential of Polyphenols"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Targets and Mechanisms
Discussion Leader: Leticia Costa-Lotufo (University of Sao Paulo, Brazil)
7:30 pm - 7:50 pm
Heike Broetz-Oesterhelt (University of Tübingen, Germany)
"Elaborate Modes of Action of Natural Product Antibiotics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
John MacMillan (University of California, Santa Cruz, United States)
"Integration of Chemical and Biological Data to Advance Natural Product Therapeutics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Erin Carlson (University of Minnesota, United States)
"Exploring the Master Regulators of Microbial Behavior"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Shinichi Nishimura (Hiroshima University, Japan)
"Omics Analyses of the Cell Membrane Using Marine Natural Products"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Miaomiao Liu (Griffith University, Australia)
"Molecular Targets Program: Drug Discovery Using Native Mass Spectrometry"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Structural Diversity from Untapped Biodiversity Libraries
Discussion Leader: Fatma Al-Awadhi (Kuwait University, Kuwait)
9:00 am - 9:20 am
Rohan Davis (Griffith University, Australia)
"Chemical and Biological Adventures with Great Barrier Reef Sourced Natural Products: The NatureBank Approach"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lilibeth Salvador (University of the Philippines, Philippines)
"Philippine Biodiversity as a Starting Point for Neuroactive Compound Discovery"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Tuan Anh Tran (University of Science and Technology of Hanoi , Vietnam)
"Natural Potential of Bacteria in Specialized Environments in Vietnam"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Tanja Grkovic (National Cancer Institute, United States)
"Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Late-Breaking Topic
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Inspirational Natural Products Research
Discussion Leader: Marcy Balunas (University of Michigan, United States)
7:30 pm - 7:50 pm
Kerry McPhail (Oregon State University, United States)
"Microbial Macrocycles that Disrupt Protein Synthesis and Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Amy Wright (Harbor Branch Oceanographic Institute, United States)
"Exploring Nature's Bounty: A Wealth of Natural Products from the Sea"
9:00 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure