Leading experts in synaptic, cellular, and circuit-level neuroscience come together to explore neural network synchronization defects due to genetic and acquired causes, unravel mechanisms of seizure generation, and design future therapies to improve the lives of individuals with epilepsy. The Epilepsy GRC will feature talks using cutting-edge technologies to advance epilepsy research. The program will focus on building a usable framework that embraces the emerging molecular, cellular, and circuit-level complexity underlying neuronal synchronization disorders. Simple models of excitation and inhibition, for example, no longer leverage our growing knowledge of the complexity of synaptic communication, cellular heterogeneity, dense neuronal connectivity, metabolic modulation of brain activity, and how they evolve during brain development. At the 2022 GRC, we will discuss the most recent advances integrating molecular, synaptic, and circuit diversity and consider how expanding our approach to network instability will accelerate the development of new treatments. A dynamic group of speakers will join other participants in talks and poster sessions over four days to help ignite the field with new ideas. The Gordon Conference offers an outstanding networking opportunity to students and senior investigators alike and the organizers are committed to fostering a diverse, welcoming, and safe community. Please join us next year in Spain for this exciting meeting!