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Mechanisms of Epilepsy and Neuronal Synchronization (GRS)

Gordon Research Seminar

Insights into Mechanisms and Therapies for Epilepsy

August 18 - 19, 2018
Chairs and

Conference Description

The Gordon Research Seminar on Mechanisms of Epilepsy and Neuronal Synchronization is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to provide new insights into the molecular, cellular, circuit, and genetic mechanisms of epilepsy and how these findings will translate to new therapeutic interventions. The meeting will showcase innovative methods for studying epilepsy and novel mechanistic translational research.

Related Meeting

This GRS will be held in conjunction with the "Mechanisms of Epilepsy and Neuronal Synchronization" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Translating New Technology in Epilepsy
Discussion Leader:
3:45 pm - 4:20 pm
"Network Models to Guide Epilepsy Surgery"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neural Circuits in Epilepsy
Discussion Leader:
7:30 pm - 7:45 pm
"Circuit-Based Therapies Rescue Cognitive Performance in a Temporal Lobe Epilepsy Mouse Model"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Altered CA1 Dendritic Integration in Chronically Acquired Epilepsy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Elucidating the Role of Enhancer of Zeste Homolog 2 (EZH2) in Epilepsy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Voltage-Gated Sodium Channel-Dependent Impairment of Action Potential Propagation Alter Cortical Network Function and Epilepsy Susceptibility"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Rescue of Astrocytic Gap Junction Coupling as a New Strategy to Prevent Epileptogenesis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Translational Approaches in Epilepsy
Discussion Leader:
9:00 am - 9:15 am
"Aberrant Adult Hippocampal Neurogenesis in Human Mesial Temporal Lobe Epilepsy"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Inhibiting Histone Deacetylase Activity Ameliorates Aberrant Synaptic Plasticity and Seizure Susceptibility in TSC2+/- Mice"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Investigating the Role of mTOR in the Development of Focal Cortical Dysplasia and Drug-Resistant Epilepsy Using Patient Stem Cell-Derived Cortical Organoids"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Dynamic Network Properties Inferred from Resting-State EEG Can Determine Whether Seizures Appear Focal or Generalized"
10:30 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Glycolytic Inhibition with 2-Deoxyglucose Preserves Inhibitory Cortical Network Function Following Traumatic Brain Injury"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers and Funding in Epilepsy Research
Discussion Leaders: and
1:30 pm - 2:30 pm
Panel Discussion
Careers and Funding in Epilepsy Research
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health - National Institute of Neurological Disorders and Stroke
Citizens United for Research in Epilepsy (CURE)
Dravet Syndrome Foundation
Epilepsy Foundation
American Epilepsy Society

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS106866. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Mechanisms of Epilepsy and Neuronal Synchronization
Additional Fee Info

Mechanisms of Epilepsy and Neuronal Synchronization
August 16 - 21, 2026


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