Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Translating New Technology in Epilepsy
Discussion Leader: Steve Danzer (Cincinnati Children's Hospital Medical Center, USA)
3:45 pm - 4:20 pm
Brian Litt (University of Pennsylvania, USA)
"Network Models to Guide Epilepsy Surgery"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neural Circuits in Epilepsy
Discussion Leader: Karen Wilcox (University of Utah, USA)
7:30 pm - 7:45 pm
Julia Kahn (University of Pennsylvania, USA)
"Circuit-Based Therapies Rescue Cognitive Performance in a Temporal Lobe Epilepsy Mouse Model"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Nicola Masala (Institute of Experimental Epileptology and Cognition Research, Germany)
"Altered CA1 Dendritic Integration in Chronically Acquired Epilepsy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Nadia Khan (University of Wisconsin-Madison, USA)
"Elucidating the Role of Enhancer of Zeste Homolog 2 (EZH2) in Epilepsy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Christopher Makinson (Stanford University, USA)
"Voltage-Gated Sodium Channel-Dependent Impairment of Action Potential Propagation Alter Cortical Network Function and Epilepsy Susceptibility"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Julia Müller (Institute of Cellular Neurosciences, University of Bonn, Germany)
"Rescue of Astrocytic Gap Junction Coupling as a New Strategy to Prevent Epileptogenesis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Translational Approaches in Epilepsy
Discussion Leader: Jenny Hsieh (The University of Texas at San Antonio, USA)
9:00 am - 9:15 am
Aswathy Ammothumkandy (University of Southern California, USA)
"Aberrant Adult Hippocampal Neurogenesis in Human Mesial Temporal Lobe Epilepsy"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Trina Basu (University of Wisconsin-Madison, USA)
"Inhibiting Histone Deacetylase Activity Ameliorates Aberrant Synaptic Plasticity and Seizure Susceptibility in TSC2+/- Mice"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Laura Bell (University of Utah, USA)
"Investigating the Role of mTOR in the Development of Focal Cortical Dysplasia and Drug-Resistant Epilepsy Using Patient Stem Cell-Derived Cortical Organoids"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Wessel Woldman (University of Exeter, United Kingdom)
"Dynamic Network Properties Inferred from Resting-State EEG Can Determine Whether Seizures Appear Focal or Generalized"
10:30 am - 10:40 am
Discussion
10:40 am - 10:55 am
Jenny Koenig (Tufts University School of Medicine, USA)
"Glycolytic Inhibition with 2-Deoxyglucose Preserves Inhibitory Cortical Network Function Following Traumatic Brain Injury"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers and Funding in Epilepsy Research
Discussion Leaders: Amanda Hernan (Larner College of Medicine, University of Vermont, USA) and Tristan Shuman (Icahn School of Medicine at Mount Sinai, USA)
1:30 pm - 2:30 pm
Panel Discussion
Careers and Funding in Epilepsy Research
Steve Danzer (Cincinnati Children's Hospital Medical Center, USA)
Jenny Hsieh (The University of Texas at San Antonio, USA)
Brian Litt (University of Pennsylvania, USA)
Karen Wilcox (University of Utah, USA)
Penny Dacks (American Epilepsy Society, USA)
Lauren Harte-Hargrove (Citizens United for Research in Epilepsy (CURE), USA)
Vicky Whittemore (National Institute of Neurological Disorders and Stroke, NIH, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
