| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Biophysical and Biological Principles |
| Discussion Leader: P. Maloney (Johns Hopkins Medical School) |
| 7:40 pm - 8:10 pm | Shimon Schuldiner (Hebrew University of Jerusalem)
"When biochemistry meets structural biology: the story of EmrE" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Werner Kuhlbrandt (Max Planck Institute for Biophysics, Frankfurt)
"EM and X-ray studies of the mechanism of ammonia transport in prokaryotes" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Ron Kaback (University of California, Los Angeles)
"Up and down and in and out with LacY" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | ABC Transporters |
| Discussion Leader: A. Davidson (Purdue University) |
| 9:00 am - 9:35 am | Heather Pinkett (California Institute of Technology)
"An inward-facing conformation of a putative metal-chelate type ABC transporter" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Jue Chen (Purdue University)
"Crystal structure of the E. coli maltose transporter" |
| 10:20 am - 10:30 am | Discussion |
| 10:20 am - 10:30 am | Coffee Break |
| 11:00 am - 11:35 am | Kaspar Locher (Institute of Molecular Biology and Biophysics, ETH Zurich)
"Structure and mechanism of bacterial ABC transporters" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Marwan Al-Shawi (University of Virginia)
"Kinetic models of ABC function" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Crossing the Bilayer |
| Discussion Leader: S. White (University of California, Irvine) |
| 7:30 pm - 8:00 pm | Don Engleman (Yale University)
"A translocating peptide that targets tumors and other acidic tissues in vivo" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Steve White (University of California, Irvine)
"Folding proteins at membrane interfaces" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Milton Saier (University of California, San Diego)
"Evolution of transmembrane transport proteins" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Gating and Conduction |
| Discussion Leader: D. Gadsby (Rockefeller University) |
| 9:00 am - 9:35 am | Youxing Jiang (University of Texas, Southwestern Medical Center)
"Ion selectivity of a NaK channel" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Rod MacKinnon (Rockefeller University)
"Gating of voltage-dependent K channels" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:35 am | Gary Yellen (Harvard Medical School)
"Reversed gating of hyperpolarization-gated HCN channels" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Tom DeCoursey (Rush Medical College)
"The voltage-gated proton channel" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New and Notable |
| Discussion Leader: C. Miller (Brandeis University) |
| 7:30 pm - 8:00 pm | Andrew Ferguson (Merck Research Laboratories)
"Crystal structure of human 5 lipoxygenase-activating protein in complex with leukotriene biosynthesis inhibitors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Travis Barnard (NIDDK, NIH)
"Post-cleavage structure of EspP, an E. coli O157:H7 autotransporter" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Anna Levine (University of Pennsylvania Medical School)
"Crystal structure of the transmembrane domain of the M2 proton channel from influenza A virus" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Ion, Solute and Water Channels |
| Discussion Leader: R. Stroud (University of California, San Francisco) |
| 9:00 am - 9:35 am | Michael Maguire (Case Western Reserve University)
"The CorA Mg2+ channel and its role in salmonella virulence" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Alan Finkelstein (Albert Einstein College of Medicine)
"Protein translocation through the anthrax toxin channel" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:35 am | Tamir Gonen (University of Washington)
"The structure of the aquaporin-0 mediated membrane junction" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | David Gadsby (Rockefeller University)
"The ion pathway through the Na,K-ATPase" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Selected Poster Talks |
| Discussion Leader: TBA |
| Presenter 1: TBA |
| Presenter 2: TBA |
| Discussion |
| Presenter 3: TBA |
| Presenter 4: TBA |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Transporters and Facilitators |
| Discussion Leader: H.R. Kaback (University of California, Los Angeles) |
| 9:00 am - 9:30 am | Chris Miller (Brandeis University)
"Slogging through the CLC transporter mechanism" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Etana Padan (Hebrew University of Jerusalem)
"NhaA: structure-driven studies of function and regulation of an Na+/H+ antiporter" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Rajini Rao (Johns Hopkins Medical School)
"Human orthologs of bacterial antiporters: phylogeny, physiology and homology modeling" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Daxiong Fu (Brookhaven National Laboratories)
"Structure and mechanism of a zinc transporter" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Edmund Kunji (MRC Cambridge)
"Substrate recognition and transport mechanism of mitochondrial carriers" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Future Challenges |
| Discussion Leader: R. MacKinnon (Rockefeller University) |
| 7:30 pm - 8:00 pm | Anjana Rao (Harvard Medical School)
"The ER store-operated CRAC calcium channel" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Lukas Novotny (University of Rochester)
"Ion exchange proteins studied by sp-FRET" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Ann McDermott (Columbia University)
"NMR of membrane proteins" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
