| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Na+-driven transporters |
| Discussion Leader: Satinder Singh (Yale) |
| 7:40 pm - 8:10 pm | Ernie Wright (UCLA)
"Functional interrogation of SGLT structural models"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:50 pm | Christine Ziegler (Max Planck, Frankfurt)
"Impact of coupling ions on secondary transport specificity and regulation"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Seok-Yong Lee (Duke)
"Structural Basis of Concentrative Nucleoside Transport"
|
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Channels |
| Discussion Leader: Rachell Gaudet (Harvard) |
| 9:00 am - 9:30 am | Francisco Bezanilla (U. Chicago)
"Voltage sensor kinetics that trace the molecular basis that make Na+ channels fast and K+ channels slow"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Rod Mackinnon (Rockefeller)
"Regulation of GIRK channel gating"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Chris Miller (Brandeis)
"A new class of ion channels that resist toxicity of fluoride anion" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Rachell Gaudet (Harvard)
"Structural insights into TRPV channel function in health and disease"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | TBA |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Transporter regulation and disease |
| Discussion Leader: Geoffrey Abbott (UC Irvine) |
| 7:30 pm - 8:00 pm | Sandra Gabelli (Hopkins)
"Cytoplasmic regulation of voltage-gated Na+ channels Nav1"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Poul Nissen (Aarhus U., Denmark)
"Na+/K+ ATPase and neurotransmitter transporters"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Geoff Abbott (UC Irvine)
"Ion channel-transporter crosstalk"
|
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Thermodynamics, kinetics, and conformational states during transport |
| Discussion Leader: Mario Amzel (Hopkins) |
| 9:00 am - 9:30 am | José Faraldo-Gómez (Max Planck, Frankfurt)
"Alternating access, proton coupling and cooperativity in the multi-drug resistance transporter ArcB" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Baron Chanda (U. Wisconsin)
"Energetics of voltage-sensing in voltage-dependent ion channels"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Lei Shi (Cornell)
"Allostery in the ion-controlled conformational dynamics of LeuT"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Hassane Mchaourab (Vanderbilt)
"The structural basis of mechanistic diversity in the LeuT fold"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Mario Amzel (Hopkins)
"Thermodynamic/kinetic analysis of the populations contributing to iodide transport by NIS"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The latest on ABC transporters |
| Discussion Leader: Jue Chen (Purdue) |
| 7:30 pm - 8:00 pm | Kasper Locher (ETH, Zurich)
"Mechanism of the B12 transporter BtuCD-F"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Markus Seeger (U. of Zurich)
"Structure-function relationships in heterodimeric ABC exporters"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jue Chen (Purdue)
"Allosteric inhibition of the maltose transporter: atomic details of inducer exclusion"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Sugar transport |
| Discussion Leader: Lucy Forrest (Max Planck, Frankfurt) |
| 9:00 am - 9:30 am | Wolf Frommer (Stanford)
"Sensing transport"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Nieng Yan (Tsinghua U.)
"Structural and mechanistical investigation of proton-driven symporters"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Lan Guan (Texas Tech)
"Structure and mechanism of a Na+-coupled sugar symporter"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Ron Kaback (UCLA)
"The Old Man and the Mechanism of Membrane Transport"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | TBA |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Handling and transporting iron |
| Discussion Leader: Susan Buchanan (NIH) |
| 7:30 pm - 8:00 pm | Philip Klebba (Kansas State U.)
"Active ion transport through an un-energized membrane"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Susan Buchanan (NIH)
"Structural basis for iron piracy by pathogenic Neisseria"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | TBA |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | TBA |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 9:00 am - 12:30 pm | Hot topics in membrane transport |
| Discussion Leader: Nancy Carrasco (Yale) |
| 9:00 am - 9:30 am | Alessio Accardi (Cornell)
"Channeling your inner lipid"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Ming Zhou (Baylor)
"Structural basis of the alternate-access mechanism in a bile acid transporter"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:40 am - 11:05 am | Stephen Long (Sloan Kettering)
"3D structure of the Ca2+ release-activated calcium channel Orai"
|
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | TBA
|
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Shimon Schuldiner (Hebrew University)
"Alternate access in a neurotransmitter transporter"
|
| 12:15 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Unusual Membrane Proteins |
| Discussion Leader: Chris Miller (Brandeis) |
| 7:30 pm - 8:00 pm | Joseph Mindell (NIH)
"Essential conformational changes in piston type transporters"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Bruno Gasnier (Université Paris Descartes)
"An unusual family of seven-helix amino acid transporters"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Filippo Mancia (Columbia)
"The Crystal Structure of CysZ Reveals a Sulfate Transporter with a Remarkable Architecture"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |