Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structure and Mechanisms of ABC Transporters
7:40 pm - 8:05 pm
"ABC Transporters Implicated in Biopolymer Translocation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Cryo-EM Studies of an ATP-Binding Cassette Lipid Transporter"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Structural Basis for Antibacterial Peptide Self-Immunity by Bacterial ABC Transporters"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Cryo-EM Snapshots of Substrate Recognition by the Multidrug Resistance Transporter MRP1"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Forefront of Structural Biology of Transport
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Structure and Mechanism of Neurotransmitter Sodium Symporters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Antigens on the Move – New Twists and Turns in Adaptive Immunity"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Structural Insights into Bacterial Lipoprotein Biosynthesis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"New Insight into the Structure of TRPV Channels"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Structure of a Eukaryotic Voltage-Gated Sodium Channel at Near Atomic Resolution"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"The Complete Structure of an Activated Open Voltage Gated Sodium Channel Reveals a Novel Gating Interaction Motif"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Living in the Lipid Bilayer
7:30 pm - 7:55 pm
"Impact of Specific Lipids on Membrane Transport, Two Sides of the Same Coin?"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Measuring the Free Energy of ClC-ec1 Dimerization in Membranes Using Single-Molecule Photobleaching Analysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Probing Membrane Protein-Lipid Interactions by Native Ion Mobility Mass Spectrometry"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Heads or Tails: Lipid Inhibitors of the Glycine Transporter, GlyT2"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure, Dynamics and Mechanisms of Secondary Transporters
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Multimodal Approach to Understanding clc-7 Function in Lysosomes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structural and Dynamic Studies of Excitatory Amino Acid Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
"Lipids and Proton Transport in Na+/H+ Antiporters"
10:40 am - 10:50 am
Discussion
10:50 am - 11:20 am
Group Photo / Coffee Break
11:20 am - 11:45 am
"Structural Insight into the Role of the Ton Complex in Transport Across the Outer Membrane"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Deciphering Ligand Induced Conformational Changes in the Sodium Galactose Transporter (SGLT)"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Interactions with Membrane Proteins
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"EmrE Sacrifices Coupling Efficiency to Achieve Multidrug Promiscuity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Probing the Structure and Ion-Coupled Mechanism of the Multidrug Transporter EmrE Using NMR Spectroscopy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Exploring Protein Sequence Information Across Nature's Hot and Cold Habitats to Understand the Functional Dynamics in the Glutamate Transporter Family"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Oligomer Interfaces of the Human Dopamine Transporter"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Energy Landscapes of Membrane Transport Proteins
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Multidimensional Free Energy Landscape Governing Structural Transitions of a Neurotransmitter Transporter in Membrane"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Dos and Don'ts of Active Transporters: An Energy Landscape Perspective"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Imaging Functional Dynamics Within Individual Transporter Proteins Using Single-Molecule FRET"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Single Molecule Studies Reveal Ligand Binding Dynamics in Pacemaker Ion Channels"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Driving Forces for Folding Membrane Proteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Ligand-Gated Channels: Recent Updates
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Allosteric Mechanisms Underlying Pentameric Ligand-Gated Ion Channel Modulation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Structure and Energy Landscapes of Ionotropic Glutamate Receptor"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Competition Between S-Components for a Common Energizing Module"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels: Structure and Function
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Insights into the Mechanisms of KATP Channel Assembly and Gating from Cryo-EM Structures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structures of K2P and TRPP Channels by X-Ray, xFEL and Cryo-EM"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
" Studies of the Epithelial Calcium Channel TRPV6"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Exploring the Complex Dynamics of an Ion Channel Voltage Sensor Domain via Computation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Helical Jackknives Control the Double-Pore K+ Uptake System KtrAB"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Omega-3 Polyunsaturated Fatty Acids Enhance Human Endothelial Cells Response by Recruiting Transient Receptor Potential Channels"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Personalized Medicine: Disease-Causing Mutations in Channels and Transporters
7:30 pm - 7:55 pm
"Failure to Prime the Dopamine 'Pump' in Autism"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Mutations in the Neutral Amino Acid Transporter LAT1 Are a Cause of Microcephaly and Autism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Murphy's Law of the Sodium Pump"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure