Mechanisms and Regulation of Gametogenesis Through Meiosis

June 9 - 10, 2018

Chairs Jessica L. Hopkins and Carla M. Abreu

Colby-Sawyer College

541 Main Street

New London, NH, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Meiosis is a forum that provides unique opportunities for graduate students, post-docs, and young faculty to discuss cutting-edge meiosis-related research and ideas in an intimate, friendly setting.

The primary focus of this meeting is to explore the mechanisms by which diploid cells give rise to unique haploid gametes during the specialized cellular division called meiosis. The research presented throughout this seminar will encompass multiple aspects of meiosis through the use of various model organisms and novel experimental techniques, with special emphasis on mechanisms pertaining to meiotic chromosome structures, meiotic DNA repair through homologous recombination, and cell cycle regulation.

Related Meeting

This GRS will be held in conjunction with the "Meiosis" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Mutation Strategies to Discover Mammalian Meiosis and Fertility Genes Discussion Leader: Paula Cohen (Cornell University, USA)
3:45 pm - 4:20 pm	Philip Jordan (Johns Hopkins University Bloomberg School of Public Health, USA) "Mutation Strategies to Discover Mammalian Meiosis Genes"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Initiation and Regulation of the Meiotic Program Discussion Leader: Bernard de Massy (Institute of Human Genetics, France)
7:30 pm - 7:45 pm	Hui Tian (The Jackson Laboratory, USA) "EWSR1 Regulates PRDM9-Dependent Histone 3 Methylation and Links Recombination Hotspots with the Chromosomal Axis"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Baolu Shi (University of Pennsylvania, USA) "Dual Functions of the ssDNA-Binding Protein RPA in Meiotic Recombination"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Diedre Reitz (University of Chicago, USA) "A Gain-of-Function Dmc1 Allele Reveals Distinct Mechanisms of Stimulation by Accessory Factors Mei5-Sae3 and Rad51"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Jasvinder Ahuja (National Cancer Institute, NIH, USA) "Divergent Mechanisms in Formation of Noncrossovers and Crossovers Revealed on Fine Structure Analysis of Meiotic Recombinants"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Shaun Peterson (Memorial Sloan Kettering Cancer Center, USA) "MSH2-Deficient Meiosis in F1 Hybrid Mice Reveals Meiotic Recombination Mechanism"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Carolyn Milano (Cornell University, USA) "Elucidating MutSγ Function During Mouse Meiosis Through the Generation of Point Mutant Mice"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Architecture and Dynamics of Meiotic Structures Discussion Leader: Scott Keeney (Memorial Sloan Kettering Cancer Center, USA)
9:00 am - 9:15 am	Haitong Hou (National Cancer Institute, NIH, USA) "When, How and Why Do Telomeres Control Meiotic Centromere Assembly"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	Luciana Previato de Almeida (Oklahoma Medical Research Foundation, USA) "Mps2/Kash5 Connects the LINC Complex to Molecular Motors on the Cytoskeleton to Mediate Chromosome Movements in Budding Yeast and Mouse Meiosis"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Chandni Ravindan (Wesleyan University, USA) "A Constitutive 2:2 Complex Between Gmc2 and Ecm11 Within the Yeast Synaptonemal Complex"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Cori Cahoon (University of Oregon, USA) "Synaptonemal Complex Architecture Facilitates Chromosome-Specific Regulation of Recombination in Drosophila"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Jason Sims (University of Vienna, Austria) "Meiotic DNA Repair in the Nucleolus Employs a NHEJ Mechanism"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	Weronika Borek (University of Edinburgh, United Kingdom) "The Ctf19/CCAN Kinetochore Complex Is Essential for Kinetochore-Microtubule Attachment in Meiosis I"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Meiotic Errors and Checkpoint Signaling Mechanisms Discussion Leader: Needhi Bhalla (University of California, Santa Cruz, USA)
1:30 pm - 1:40 pm	Zhouliang Yu (University of California, Berkeley, USA) "The DNA Damage Response Regulates Chromosome Axis Assembly During C. elegans Meiosis"
1:40 pm - 1:45 pm	Discussion
1:45 pm - 1:55 pm	Viji Subramanian (New York University, USA) "Ends: A Means to Establishing Chromosome Size Bias"
1:55 pm - 2:00 pm	Discussion
2:00 pm - 2:10 pm	Stephen Wellard (Johns Hopkins Bloomberg School of Public Health, USA) "Regulation of Synaptonemal Complex Disassembly by Aurora Kinases During Mouse and Human Meiosis"
2:10 pm - 2:15 pm	Discussion
2:15 pm - 2:25 pm	Kostika Sofroni (University of Hamburg, Germany) "Control of Meiotic Progression Through Cyclin-Dependent Kinase Complexes"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes