Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Molecular Mechanisms of the Blood-Brain Barrier
Discussion Leader: Parastoo Hashemi (Imperial College London, United Kingdom)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Richard Daneman (UCSD, United States)
"How Does the Blood-Brain Barrier Regulate Brain Function and Behavior?"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Late-Breaking Topic
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Late-Breaking Topic
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Rosemary Cater (Institute for Molecular Bioscience, University of Queensland, Australia)
"Structural and Molecular Basis of Choline Uptake into the Brain by FLVCR2"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plant, Microbe and Pathogen Transporters
Discussion Leader: Zachary Freyberg (University of Pittsburgh, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Camilo Perez (University of Georgia, United States)
"Mechanism of a Checkpoint Flippase Controlling Teichoic Acid Translocation in Pneumococcus"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Heather Pinkett (Northwestern University, United States)
"Navigating the Ins and Outs of the Transport Cycle"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Chloe Martens (Université Libre de Bruxelles, Belgium)
"Beyond Membrane Transport Proteins Structure: Insights into Dynamics from H/D Exchange Coupled to Mass Spectrometry"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ruben Gonzalez (Columbia University, United States)
"smFRET to Probe Structural Dynamics of Membrane Transport Proteins"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Annamaria De Rosa (The Australian National University, Australia)
"Exploring Plant Aquaporin Diversity for Harvesting Key Solutes from Waste Liquids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Rajini Rao (Johns Hopkins University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms of Pumps and Channels
Discussion Leader: Kenton Swartz (National Institutes of Health, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Ryan Hibbs (University of California San Diego, United States)
"Native Muscle ACh Receptor Structure in Developing Synapses"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Late-Breaking Topic
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Late-Breaking Topic
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Emad Tajkhorshid (University of Illinois, United States)
"Mechanism and Energetics of AE1 Elevator Transport Cycle in Red Blood Cells"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Brain Transporters in Health and Disease
Discussion Leader: Harald Sitte (Medical University of Vienna, Austria)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Don van Meyel (McGill University, Canada)
"Functional Impact of Patient-Derived Variants of EAAT1/SLC1A3, a Dual-Function Glutamate Transporter/Chloride Channel Involved in Episodic Ataxia"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Erin Calipari (Vanderbilt University, United States)
"Stimulant Effects on the Dopamine System are Sexually Dimorphic and Sensitive to Ovarian Hormone Cycles"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Lynette Daws (University of Texas Health Science Center at San Antonio, United States)
"Organic Cation Transporter 3: A Crucial Player in the Actions of Alcohol and Amphetamine"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Aravind Penmatsa (Indian Institute of Science, India)
"Insights into Substrate and Inhibitor Recognition in GABA Reuptake Machinery"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unconventional Transporters: Elevators, Dual Function, and Hybrid Transporters
Discussion Leader: Olga Boudker (Weill Cornell Medicine, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Inga Hänelt (Goethe University Frankfurt, Germany)
"Post-Translational Regulation of the K+ Pump KdpFABC"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Raimund Dutzler (University of Zurich, Switzerland)
"TTYH Proteins as Catalysts of Lipid Transfer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Da-Neng Wang (NYU Langone Health, United States)
"Reaction Cycle of the Sodium-Dependent Carboxylate Transporters"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters of Anions, Cations and Metals
Discussion Leader: Rajini Rao (Johns Hopkins University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Joseph Mindell (NINDS, United States)
"Mechanism of ClC-7 Inhibition by Lysosomal Phosphoinosides"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Christopher McDevitt (University of Melbourne, Australia)
"The Structural and Mechanistic Determinants of Bacterial Manganese Import"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Late-Breaking Topic
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rachelle Gaudet (Harvard University, United States)
"Conformational Cycle and Substrate Selectivity in Nramp-Family Metal Transporters"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Atsuko Yamashita (Okayama University, Japan)
"Structure and Mechanism of Oxalate Transporter OxlT in an Oxalate-Degrading Bacterium in the Gut Microbiota"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transporter Drug Discovery: Perspectives from Pharma and Industry
Discussion Leader: Jonathan Javitch (Columbia University / New York State Psychiatric Institute, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Enrico Girardi (Solgate GmbH, Austria)
"Unlocking Solute Carrier Drug Discovery by Cell-Based Technologies"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Short Talk Selected from Poster Abstracts
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Short Talk Selected from Poster Abstracts
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Andreu Viader (Jnana Therapeutics, United States)
"Discovery and Characterization of JNT-517, a First-in-Class Inhibitor of SLC6A19 for the Treatment of Phenylketonuria"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Transporter Function and Dysfunction in Metabolism, Obesity and Cancer
Discussion Leader: Nancy Carrasco (Vanderbilt University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Seok-Yong Lee (Duke University School of Medicine, United States)
"Methotrexate Recognition by the Human Reduced Folate Carrier SLC19A1"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Ambre Bertholet (UCLA, United States)
"Redefining the Mechanism of Action of Chemical Uncouplers for a New Generation of Antiobesogenic Drugs"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Louise Fets (MRC Laboratory of Medical Sciences/ Imperial College London, United Kingdom)
"Membrane Transporters in Cancer Therapeutic Response and Resistance"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Innovative Approaches to Study Membrane Transporter Function
Discussion Leader: Susan Amara (National Institute of Mental Health, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Ariel Furst (Massachusetts Institute of Technology, United States)
"In vitro Platforms to Study and Deploy Membrane-Associated Proteins"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Randy Blakely (Florida Atlantic University Stiles-Nicholson Brain Institute, United States)
"Serotonin Transporter Regulation: From Molecules and Circuits to Disease"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Aurelio Galli (The University of Alabama at Birmingham, United States)
"Hydrolytic Regulation of Neuronal Activity and Behaviors by Non-Invasive Xray Technology"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure