Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Advances in Metallocofactor Spectroscopy
Discussion Leader: Daniel Suess (Massachusetts Institute of Technology, United States)
7:40 pm - 8:20 pm
R. David Britt (University of California, Davis, United States)
"Biosynthesis and Semi-Synthesis of the Catalytic H-Cluster of Fe-Fe Hydrogenase"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Serena DeBeer (Max Planck Institute for Chemical Energy Conversion, Germany)
"Illuminating the Deepest Secrets of Metallocofactors"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Electrifying Metallocofactors
Discussion Leader: Sean Elliott (Boston University, United States)
9:00 am - 9:30 am
Alison Parkin (University of York, United Kingdom)
"Expanding the Enzyme Electrochemistry Toolkit: Tuning in to Slow and Fast Redox Processes"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Kara Bren (University of Rochester, United States)
"Bioinspired Electrocatalytic Systems for Small Molecule Activation"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Charles McCrory (University of Michigan, United States)
"Modulating Electrocatalytic Activity and Selectivity of Polymer-Catalyst Composites by Controlling the Catalysts' Microenvironments"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modeling Multimetallic Cofactors
Discussion Leader: Eunsuk Kim (Brown University, United States)
7:30 pm - 8:00 pm
Theodore Betley (Harvard University, United States)
"Reactivity and Electronic Structure of Synthetic Clusters as Mimics of Enzymatic Metallocofactors"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Neal Mankad (University of Illinois Chicago, United States)
"Synthetic Cu4 S Clusters that Mimic the CuZ Site of Nitrous Oxide Reductase"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Leslie Murray (University of Florida, United States)
"Mimicking Polynuclear Metal Active Sites: Reactivity of Weak-Field Ligated Di and Trinuclear Complexes"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nitrogenase M-Clusters: Evolution, Modeling, and Chemistry Beyond Nitrogen Fixation
Discussion Leader: Oliver Einsle (University of Freiburg, Germany)
9:00 am - 9:30 am
Olaf Rudiger (Max Planck Institute for Chemical Energy Conversion, Germany)
"FTIR Spectroelectrochemistry of MoFe Nitrogenase"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Patricia Dos Santos (Wake Forest University, United States)
"Biological Fe-S Intermediates in the Synthesis of Nitrogenase Metalloclusters"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Patrick Holland (Yale University, United States)
"Synthetic Iron-Nickel-Sulfur Clusters and Insight into Electronic Structure and Mechanism of Anaerobic CO Dehydrogenase Enzymes"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Justin North (Ohio State University, United States)
"Nitrogenase Superfamily Catalysts for Organic Sulfur Assimilation and Hydrocarbon Production by Bacteria"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nitrogen Beyond Fixation
Discussion Leader: Jonathan Caranto (University of Central Florida, United States)
7:30 pm - 8:00 pm
Boran Kartal (Max Planck Institute for Marine Microbiology, Germany)
"Solving Metabolic Puzzles: Molecular Mechanism of Anaerobic Ammonium Oxidation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Pierre Moenne-Loccoz (Oregon Health and Science University , United States)
"The Confounding Reactivity of Mycobacterial Hemerythrin-Like Proteins Toward Nitric Oxide and Other Nitrogen Oxide Species"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Nicolai Lehnert (University of Michigan, United States)
"What is the Nature of the Key “Intermediate I” in Cytochrome P450 NO Reductase?"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Hydrogenases: Simple Substrates, Not-So-Simple Metallocofactors
Discussion Leader: James Birrell (University of Essex, United Kingdom)
9:00 am - 9:30 am
Ulf-Peter Apfel (Ruhr University Bochum & Fraunhofer UMSICHT, Germany)
"Unlocking Enzymatic Mimicry: Maximizing Efficiency Through Optimising Local Reaction Environments"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Chris Greening (Monash University, Australia)
"Discovery and Characterization of Novel [NiFe]-, [FeFe]- and Hybrid Hydrogenases"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Michael Rose (University of Texas at Austin, United States)
"Scaffold-Based Models of (Mono) [Fe]-Hydrogenase to Demonstrate Molecular Dynamics and Flexibility: The Thematic Third Coordination Sphere"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Harnessing Oxygen
Discussion Leader: David Goldberg (Johns Hopkins University, United States)
7:30 pm - 8:00 pm
Jonathan Rittle (University of California Berkeley, United States)
"New Biological Roles for Manganese"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Kallol Ray (Humboldt University Berlin, Germany)
"Hydrogen Bonding Mediated Dioxygen Activation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Julie Kovacs (University of Washington, United States)
"The Role of Thiolates in Creating More Reactive Iron Dioxygen Intermediates"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Bespoke Metalloproteins
Discussion Leader: Hannah Shafaat (University of California, Los Angeles, United States)
9:00 am - 9:30 am
Takashi Hayashi (Osaka University, Japan)
"Construction of New Metalloenzymes by Replacing Native Heme in Hemoproteins with Artificially Created Metalloporphyrinoids"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Lisa Olshansky (University of Illinois , Urbana-Champaign, United States)
"Adventures in Artificial Metalloprotein Design"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Lionel Cheruzel (Genentech, United States)
"Unusual Biotransformations: An Industry Perspective"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Woon Ju Song (Seoul National University, South Korea)
"Design of Artificial Metalloenzymes: Expanding the Chemical Space of Metallocofactors within Protein Environments"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Advances in Heme Biochemistry: Trafficking, Regulation and Future Prospects
Discussion Leader: Ekaterina Pletneva (Dartmouth College, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Emma Raven (University of Bristol, United Kingdom)
"The Ever-Changing Landscape of Heme Biology: From Catalysis to Regulation"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Dennis Stuehr (Cleveland Clinic, United States)
"A Complete Heme Trafficking Pathway from Mitochondria to Target Proteins in Mammalian Cells and Studies on Its Regulation"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure