Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Metalloprotease and Metalloprotease Inhibitor Structure and Post-Translational Modifications
Discussion Leader: Jordan Lambert (University of East Anglia, United Kingdom)
3:15 pm - 3:20 pm
Opening Remarks
3:20 pm - 3:35 pm
Lise Boon (KU Leuven, Belgium)
"Functional Regulation of ProMMP-9 by Posttranslational Modifications"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Chek Ziu Koo (University of Birmingham, United Kingdom)
"TspanC8 Tetraspanins Are Essential Subunits of an ADAM10 Scissor Complex"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Metalloprotease Intracellular and Pericellular Functions
Discussion Leader: Maria Cristina Miranda Vergara (University of Notre Dame, USA)
5:30 pm - 5:45 pm
Valentina Gifford (University of Oxford, United Kingdom)
"Intracellular Trafficking of the Invasion Promoting Cell Surface Proteinase MT1-MMP"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Jordan Lambert (University of East Anglia, United Kingdom)
"The Interplay Between ADAMTS-1 and Syndecan-4 Regulates Cell Adhesion, Migration and Angiogenesis"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Sebastian Gnosa (Biotech Research and Innovation Centre (BRIC), Denmark)
"Unravelling the ADAM17 Regulation by PP2A-B56"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Benjamin Schoeps (Klinikum Rechts der Isar, Technical University of Munich, Germany)
"Pathophysiological TIMP-1 Levels Trigger Formation of Neutrophil Extracellular Traps via Induction of CD63/ERK Signaling"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
David Peeney (National Cancer Institute, NIH, USA)
"TIMP-2 Function Is Regulated by the Composition of the Cellular Microenvironment"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Brandon Chan (University of Alberta, Canada)
"MMP Inhibitors Attenuate Doxorubicin Cardiotoxicity by Preventing Intracellular and Extracellular Matrix Remodeling"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Metalloproteases in Disease and Metalloprotease-Based Diagnostics / Keynote Session: ADAM-Induced Cancer Progression
Discussion Leader: Benjamin Schoeps (Klinikum Rechts der Isar, Technical University of Munich, Germany)
9:00 am - 9:15 am
Elizabeth Harper (University of Notre Dame, USA)
"Age-Related Changes in the Peritoneal Microenvironment Enhance Ovarian Cancer Metastasis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Maria Cristina Miranda Vergara (University of Notre Dame, USA)
"Stromal Matrix Metalloproteinase 3 Regulates Immune Cell Recruitment to Inhibit Primary Tumor Burden in Breast Cancer"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Chen Hao Lo (Moffitt Cancer Center, USA)
"Host-Derived Matrix Metalloproteinase-13 Contributes to the Progression of Multiple Myeloma"
9:55 am - 10:00 am
Discussion
10:00 am - 10:45 am
Marie Kveiborg (University of Copenhagen, Denmark)
"ADAM-Induced Cancer Progression: Functions and Regulatory Pathways"
10:45 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
Discussion Leader: Lise Boon (KU Leuven, Belgium)
1:30 pm - 2:30 pm
Panel Discussion
Professional Options for Protease Researchers
Achim Krüger (Klinikum Rechts der Isar, Technical University of Munich, Germany)
Roosmarijn Vandenbroucke (VIB, Ghent University, Belgium)
Marie Kveiborg (University of Copenhagen, Denmark)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes