Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Radiation Protection
Discussion Leader: Rebecca Abergel (University of California, Berkeley, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Gayle Woloschak (Northwestern University, United States)
"X-Ray Microscopy for Detection of Metals in Cells and Tissues"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Sara Dumit (Los Alamos National Laboratory, United States)
"Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Julian Rees (HOPO Therapeutics, Inc., United States)
"Advanced Development of the Actinide Decorporation Agent HOPO 14-1"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Clinical Advances for Metals in Medicine
Discussion Leader: Linda Vahdat (Dartmouth Hitchcock Medical Center, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Hongzhe Sun (The University of Hong Kong, Hong Kong SAR China)
"Metallo-Agents for Emerging Infectious Diseases: Opportunities and Challenges"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Mark Bazett (Bold Therapeutics, Inc, Canada)
"Clinical Development of BOLD-100, a Ruthenium-Based Therapeutic Currently in Phase 2 Studies for the Treatment of Advanced Gastrointestinal Cancers"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Paul Donnelly (University of Melbourne, Australia)
"Imaging and Therapy with Metal Radionuclides"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Oluwatayo Ikotun (University of California, Los Angeles, United States) and Adoracion Gómez Quiroga (Universidad Autonoma de Madrid, Spain)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stimuli-Responsive Metallodrugs as Emerging Therapeutics
Discussion Leaders: Sherri McFarland (The University of Texas at Arlington, United States) and Jose Ruiz (Universidad de Murcia, Spain)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Kenneth Kam-Wing Lo (City University of Hong Kong, Hong Kong SAR China)
"Utilization of the Photophysical and Photochemical Properties of Transition Metal Complexes for the Design of Bioorthogonal Imaging Reagents and Photosensitizers"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Sylvestre Bonnet (Leiden University, The Netherlands)
"Ruthenium-Based Photoactivated Chemotherapy in Vivo"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Pingyu Zhang (Shenzhen University, China)
"The Driving Therapy of Metal-Based Drugs"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metal-Based Therapeutics for Infectious Diseases
Discussion Leaders: Maribel Navarro (Universidade Federal de Juiz de Fora/ Federal University of Juiz de Fora, Brazil) and Nils Metzler-Nolte (Ruhr University Bochum, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Angelo Frei (University of Bern, Switzerland)
"Leveraging Combinatorial Synthesis to Discover Novel Metalloantibiotics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Jeannine Hess (King's College London / The Francis Crick Institute, United Kingdom)
"Rational Design of Metal-Containing and Metal-Binding Antimicrobial Agents"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Heveline Silva (Universidade Federal de Minas Gerais (UFMG), Brazil)
"Gold-Based Compounds as Selective Anti-Leishmanial Metallodrugs"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Hitomi Sawai (Nagasaki University & National Institutes of Natural Sciences, Japan)
"Structural Basis for the Sensing and Transport of Iron Nutrients as a Basis for Drug Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Pijus Kumar Sasmal (Jawaharlal Nehru University, India)
"Lighting-up Iridium AIEgens for Antimicrobial Therapy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Addressing Health Disparities and Increasing Diversity and Inclusion in Biomedical Research
Discussion Leaders: Maria Contel (Brooklyn College and CUNY, United States) and Gilles Gasser (Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, France)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Melissa Davis (Morehouse School of Medicine and New York Genome Center, United States)
"Resolving Race vs Ancestry in Cancer Disparities Research – The DARC Side of Breast and Prostate Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Terri Chambers (American Chemical Society, United States)
"Advancing Equity and Inclusion in STEM Research: Strategies for Student Recruitment and Engagement"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Katherine Franz (Duke University, United States)
"Setting the Table for Inclusive Excellence in Science: A Chair’s Perspective"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Udunna Anazodo (Montreal Neurological Institute, McGill University, Canada, Canada)
"Addressing Disparities in Dementia Imaging in Africa"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drug Delivery and Targeted Therapies
Discussion Leaders: Angela Casini (Technical University of Munich, Germany) and Seth Cohen (UC San Diego, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Petra Heffeter (Medical University of Vienna, Austria)
"Exploiting Specific Characteristics of Malignant Tissue for Anticancer Therapy"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Guangyu Zhu (City University of Hong Kong, Hong Kong SAR China)
"Controllable Activation and Delivery of Platinum Anticancer Prodrugs"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Oluwatayo Ikotun (University of California, Los Angeles, United States)
"Imaging Immune Response to Targeted Therapeutic Interventions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Farukh Arjmand (Aligarh Muslim University, India)
"Synthesis of Graphene Oxide Loaded Copper(II) Complexes for Cancer-Targeted Therapy: Evaluation of Binding with Target tRNA, In Vitro Cytotoxicity and In Vivo Genotoxic Potency"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Shanta Dhar (University of Miami Miller School of Medicine, United States)
"Cisplatin Prodrug Loaded Engineered Nanomaterials in Pursuit to Manage Aggressive Cancers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Metallomics
Discussion Leader: Hugh Harris (The University of Adelaide, Australia)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Samuel Meier-Menches (University of Vienna, Austria)
"Mode of Action Deconvolution in Metallodrug Discovery"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Orazio Vittorio (University of New South Wales, Lowy Cancer Research Centre, Australia)
"Disrupting Tumor Immune Evasion: Copper Chelation as a Promising Intervention Strategy"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Arthur Tinoco (University of Puerto Rico Rio Piedras, United States)
"Exploring Transferrin and Small Molecule Chelator Regulation of Titanium(IV) Bioactivity"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unconventional Metal-Based Therapeutics
Discussion Leaders: Phoebe Glazer (North Carolina State University, United States) and M. Concepción Gimeno (CSIC-Universidad de Zaragoza, Spain)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Justin Wilson (Cornell University, United States)
"Mitochondrial Ion Channel Inhibitors as Cytoprotective Agents"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Kogularamanan Suntharalingam (University of Leicester, United Kingdom)
"Towards the Development of Anti-Cancer Stem Cell Metallopharmaceuticals"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Rianne Lord (University of East Anglia, United Kingdom)
"Understanding the Anticancer Intracellular Modes of Action of Vanadium Compounds"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Maria (Masha) Babak (City University of Hong Kong, Hong Kong SAR China)
"Insights into the Mechanism of Action of Anticancer G Complexes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Johannes Karges (Ruhr University Bochum, Germany)
"Treating Tumor Metastases Using Immunogenic Cell Death Inducing Metal Complexes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Theranostics
Discussion Leader: Jason Lewis (Memorial Sloan Kettering Cancer Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Lisa Bodei (MSKCC, United States)
"Clinical Experience with Theranostics: The Expansion to Radiometals"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Julie Sutcliffe (University of California, Davis, United States)
"The Integrin Alpha v Beta 6 as a Target for PRRT"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Caterina Ramogida (Simon Fraser University & TRIUMF, Canada)
"Chelation of Radiometals for Incorporation into Theranostic Radiopharmaceuticals"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure