Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Targeting Multidrug Efflux Systems in Cancer, Infections, and Beyond
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Structural and Mechanistic Studies of Multi-Drug Transporters of the ABC, OATP, and MATE Families"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Efflux Pump Inhibitors and Resistance Breakers"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Elucidation of Transporter Structures and Mechanisms Using Integrated Methods
9:00 am - 9:20 am
"Gating of the Loosely-Coupled Transporter EmrE"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Backbone of Multidrug Efflux Within RND-Type Pumps"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Structural Basis for the Transport and Regulation Mechanism of Multidrug Transporter MRP2"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Species Differences in the ABCG2 Transporter"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Capturing MdfA Dynamics: A Cryo-EM Study of Outward-Facing States Stabilized by Antibody Fragment"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Conformational Dynamics of MsbA"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Physiological Roles of Transporters
6:00 pm - 6:20 pm
"Unraveling the Role of ABCC4 in Hepatic Steatosis, Adiposity, and Metabolic Syndrome"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Elucidation of the Function of ABCB5: Dimerization of ABCB5ß with ABCB6 and ABCB9 and Generation of ABCB5 Knockout Mice"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Structure-Function Study of the Pseudopaline Original Export Through the Membranes of Pseudomonas Aeruginosa"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"MCT10 - A Surprising Efflux Transporter"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Role of Efflux Transporters in Androgen Clearance and Recycling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters in Drug Resistance and Disease
9:00 am - 9:20 am
"Targeting Drug-Tolerant Persister Cells by Inhibiting P-Glycoprotein to Prevent Therapy Resistance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Precision Therapies in CFTR-Related Disorders"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"The Role of Klebsiella Pneumoniae Multi-Drug Efflux Systems and Permeability Barriers in Antibiotic Susceptibility and Persistence"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Towards a Predictive Model of Compound Efflux Susceptibility in Escherichia Coli "
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Role of Efflux Pumps in Potentiating the Evolution of Untreatable Multi-Drug Resistant Strains of Mycobacterium Tuberculosis"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Downregulation of Placental P-Glycoprotein and BCRP in Lupus and Preeclampsia: Clinical to Preclinical Evaluation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Posttranslational Modifications and Regulation of Multidrug Resistance Pumps
6:00 pm - 6:20 pm
"ABCC Transporters Achieve Native Conformation through Biogenic Domain-Domain Coupling Mechanisms"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Investigating the Interplay Between AdeIJK RND Pump and its Transcriptional Regulator, AdeN, in Acinetobacter Baumannii"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Beyond the Binary: Cyclic AMP Egress Through ABCC1 in Human Airway Smooth Muscle"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Activation and Auto-Inhibition of Yeast Cadmium Factor 1 by an Intrinsically Disordered Domain"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"The Linker Domain in ABCB1/P-Glycoprotein. “Just Spaghetti?” "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transporter Functionality and Activity through Experimental and Computational Approaches
9:00 am - 9:20 am
"The Drug Efflux Pump Pdr5 from Yeast - Insights from Structures"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Structure of RND Transporter that Expands Substrate Specificity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:45 am
"Capturing a New Inward-Facing Conformation in a Multidrug ABC Efflux Pump"
10:45 am - 10:50 am
Discussion
10:50 am - 11:10 am
"Simultaneous Binding of Lipids and Ligands to the Inner Cavity of ABC Transporters and Potential Impact on Transport"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Demystifying Proton Transport and Energisation in the Multidrug Tripartite Efflux Pump AcrAB-TolC"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Campylobacter Jejuni: Insights into Glycosylated Efflux Pumps from Molecular Dynamics Simulations"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"From Proteoliposomes to Precision: Direct In Vitro Evidence of Substrate Specificity in the MexAB-OprM Efflux Pump from Pseudomonas Aeruginosa"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interactions of Multidrug Efflux Transporters with Their Environment
6:00 pm - 6:20 pm
"ABCCs and the Cellular Handling of Arsenic Metabolites"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"AcrR Co-Regulates Multidrug Efflux, Metabolism and Other Functions"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Lipid Transport Pathways via the Quaternary Ammonium Compound (QacA) Efflux Pump"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"How are Multidrug Efflux and Biofilm Formation Linked?"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Relationship Between Human Liver PFAS Concentration and Drug Transporter Expression"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Overcoming Multidrug Resistance through Transporter Targeting Methods
9:00 am - 9:20 am
"Structure, Dynamics, and Inhibition of the Staphylococcus Aureus Efflux Transporter NorA"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Pharmacologic Inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Targeting the Outer Membrane Factor TolC as an Alternative Approach for AcrAB-TolC Efflux Pump Inhibition"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Identifying Efflux Pump Inhibitors through Structural and Ligand-Based Approaches and Determining Their Effect on Antimicrobial Resistance and Virulence in Pseudomonas Aeruginosa"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Allosteric Efflux Pump Inhibitors: A Strategy to Tackle Antimicrobial Resistance in Enterobacterales Infections"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Chemical Synthesis of Natural Product Leads as P-GP Inhibitors of Human ABCB1"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Targeting the Gateway of Drug Efflux: Cryo-EM Structures of TolC and Strategy of Protein-Based Inhibitors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Translating Transporter Science to the Clinic
6:00 pm - 6:20 pm
"Cerastecins Inhibit the ABC Transporter MsbA in an Important Drug-Resistant Bacterial Pathogen"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-Positive Bacteria"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Bacterial Efflux Pump Inhibitors: From Bench to Bedsides"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"GARDP Discovery and Exploratory Research - Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux Pumps"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Molecular Checkmate: Exploiting Multi-Drug Efflux for Therapeutic Immunogenicity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure