Saturday
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1:30 pm - 4:30 pm |
Arrival and Check-in
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3:00 pm - 3:15 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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3:15 pm - 4:00 pm |
In Silico Approaches and Methods in Structural Biology
Discussion Leader: Evan Green (University of California, San Francisco, USA)
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3:15 pm - 3:25 pm |
Sarah Rottet (CSIRO Land & Water, Australia)
"Toward Synthetic Membranes: Functional Reconstitution of Two ABC Exporters in Hybrid Lipid-Polymer Vesicles"
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3:25 pm - 3:30 pm |
Discussion
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3:30 pm - 3:40 pm |
Manu Singh (University of Manitoba, Canada)
"Functional Difference Between MexXY-OprM and MexXY-OprA RND Efflux Systems in Pseudomonas aeruginosa"
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3:40 pm - 3:45 pm |
Discussion
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3:45 pm - 3:55 pm |
Anne Mahringer (Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Germany)
"Arylhydrocarbon Receptor-Mediated Signaling of ABC Transporters and Solute Carriers in Human Renal Proximal Epithelial Tubular Cells and Proximal Renal Tubules from Killifish"
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3:55 pm - 4:00 pm |
Discussion
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4:00 pm - 5:30 pm |
Poster Session
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5:30 pm - 7:30 pm |
Molecular Mechanisms Driving to Multi-Drug Efflux of Antibiotics or Anti-Cancer Drugs
Discussion Leader: Anne Mahringer (Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Germany)
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5:30 pm - 5:45 pm |
Ankita Nag (Indian Institute of Technology Bombay, India)
"Characterization and Regulation of a Novel Efflux Pump from the Major Facilitator Superfamily in Streptomyces coelicolor M145"
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5:45 pm - 5:50 pm |
Discussion
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5:50 pm - 6:05 pm |
Onat Kadioglu (Johannes Gutenberg University of Mainz, Germany)
"Drug Resistant Cancer Cells Can Be Targeted by Oridonin"
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6:05 pm - 6:10 pm |
Discussion
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6:10 pm - 6:25 pm |
Alexandre Tetard (Laboratoire Chrono-Environnement (UMR 6249), University of Franche-Comté, France)
"Susceptibility of Pseudomonas aeruginosa to Antibiotics Can Be Compromised by Essential Oils"
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6:25 pm - 6:30 pm |
Discussion
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6:30 pm - 6:45 pm |
Himansha Singh (University of Cambridge, United Kingdom)
"ATP-Dependent Substrate Transport by the ABC Transporter MsbA Is Proton-Coupled"
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6:45 pm - 6:50 pm |
Discussion
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6:50 pm - 7:05 pm |
Jennifer Reimche (Emory University School of Medicine, USA)
"Single Amino Acid Changes in MtrD Impact Susceptibility of Neisseria gonorrhoeae to Macrolides"
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7:05 pm - 7:10 pm |
Discussion
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7:10 pm - 7:25 pm |
Hélène Puja (Laboratoire Chrono-Environnement (UMR 6249), University of Franche-Comté, France)
"TtgABC and a Novel RND Efflux Pump ParXY Are Co-Regulated by a Two-Component System in Pseudomonas putida"
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7:25 pm - 7:30 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Sunday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 11:00 am |
Keynote Session: Physiological Role of Efflux Systems / Insights into Drug Discovery and Development
Discussion Leader: Hélène Puja (Laboratoire Chrono-Environnement (UMR 6249), University of Franche-Comté, France)
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9:00 am - 9:20 am |
Alexandra Fernandes (UCIBIO, Universidade Nova de Lisboa , Portugal)
"A Battle of the Titans: Strategies to Fight Multidrug Resistance in Cancer"
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9:20 am - 9:25 am |
Discussion
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9:25 am - 9:35 am |
Phuong Nguyen (University of Georgia, USA)
"Molecular Mechanism Underlying P-Glycoprotein Efflux of Anthracycline Drugs"
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9:35 am - 9:40 am |
Discussion
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9:40 am - 9:50 am |
Adam Green (University of Tennessee / Center for Molecular Biophysics, Oak Ridge National Laboratory, USA)
"Discovery of New Efflux Pump Inhibitors that Interact with AcrA of the Escherichia coli AcrAB-TolC Efflux Pump"
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9:50 am - 9:55 am |
Discussion
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9:55 am - 10:05 am |
Diego Novoa (Arizona State University, USA)
"Substrates of the Anaerobic Efflux Pump MdtEF-TolC"
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10:05 am - 10:10 am |
Discussion
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10:10 am - 10:20 am |
Alaska Pokhrel (Macquarie University, Australia)
"Investigating the Regulatory Circuits Controlling Multidrug Efflux Pump Expression in Acinetobacter baumannii"
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10:20 am - 10:25 am |
Discussion
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10:25 am - 10:35 am |
Dhenesh Puvanendran (CNRS / Université Paris Diderot, France)
"Reconstitution of the Activity of Efflux Pump into Proteoliposomes"
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10:35 am - 10:40 am |
Discussion
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10:40 am - 10:50 am |
Stephanie Nagy (Macquarie University, Australia)
"Towards Single-Molecule Characterization of the Alternating Access Mechanism in MdfA"
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10:50 am - 10:55 am |
Discussion
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10:55 am - 11:00 am |
General Discussion
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11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 2:30 pm |
Mentorship Component: Scientific Networking and Grant Writing
Discussion Leader: Edna Ooko (National Cancer Institute, NIH, USA)
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1:30 pm - 2:30 pm |
Panel Discussion
Scientific Networking and Grant Writing
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Lauren Aleksunes (Rutgers University, USA)
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Suresh Ambudkar (National Cancer Institute, NIH, USA)
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Franco Lombardo (Alkermes, USA)
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Martin Picard (Institut de Biologie Physico-Chimique, CNRS, France)
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2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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3:00 pm |
Seminar Concludes
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