| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BACKGROUND: CLINICAL NEEDS & CLINICAL CONTROVERSIES IN JOINT REPAIR |
| 7:30 pm - 7:35 pm | Cy Frank
"Welcome" |
| 7:35 pm - 7:45 pm | Discussion Leader: Stefan Lohmander (Lund University)
"Joint Repair: Do We Need It? Can We Do It? Is It Good (And For Whom)? Can We Prove It?" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:20 pm | Lars Engebretsen (Ulleval Hospital)
"What Is The Evidence?" |
| 8:20 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:10 pm | Ewa Roos (Lund University)
"The Outcome: Who And What Do We Ask?" |
| 9:10 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | THE SCIENCE: JOINTS, TISSUES & CELLS - HOW DO WE EVALUATE SUCCESS? |
| Discussion Leaders: David Butler (University of Cincinnati) & Jack Lewis (University of Minnesota) |
| 9:00 am - 9:10 am | David Butler (University of Cincinnati)
"Introduction - Background & Rationale" |
| 9:10 am - 9:25 am | Scott Tashman (Wayne State University)
"Design/Evaluation Criteria For The Joint" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:50 am | Al Banes (University of North Carolina)
"Biological Design/Evaluation Criteria" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:45 am | Braden Fleming (Brown University)
"Design/Evaluation Criteria For Tendons & Ligaments" |
| 10:45 am - 10:55 am | Discussion |
| 10:55 am - 11:10 am | Marc Levenston (Georgia Institute of Technology)
"Design/Evaluation Criteria For Articular Cartilage" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:35 am | Dawn Elliot (University of Pennsylvania)
"Design/Evaluation Criteria For Intervertebral Disc" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:00 pm | Robert Guldberg (Georgia Institute of Technology)
"Design/Evaluation Criteria for Bone" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:30 pm | Jack Lewis (University of Minnesota)
"Summary & Discussion" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THE CONTROVERSIES & NEXT STEPS TOWARD SUCCESS - ARE WE THERE YET? |
| Debate Discussion Leader: Anthony Ratcliffe (Synthasome, Inc.) |
| 7:30 pm - 7:50 pm | Kathleen Derwin (Cleveland Clinic)
"Tissue Engineering For Rotator Cuff Repair" |
| 7:50 pm - 8:10 pm | Kristi Anseth (University of Colorado)
"Cartilage Tissue Engineering, Fact and Fiction" |
| 8:10 pm - 8:30 pm | Howard Seeherman (Wyeth)
"Development of BMP-Tissue Engineered Products For Musculoskeletal Applications" |
| 8:30 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TISSUE ENGINEERING I - THE SCIENCE: CELLS, TISSUES, SCAFFOLDS, STRESSES & STRAINS |
| Discussion Leader: David Kaplan (Tufts University) |
| 9:00 am - 9:20 am | Robert Fajardo (Harvard University)
"Micro CT Based Studies of Tissue Engineered Mineralized Constructs" |
| 9:20 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Rita Kandel (University of Toronto)
"What Does Mechanical Stimulation do to Tissue Engineered Cartilage?" |
| 9:55 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:00 am | Farshid Guilak (Duke University)
"Functional Tissue Engineering of Articular Cartilage" |
| 11:00 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Clark Hung (Columbia University)
"Physiologic Loading for Cartilage Tissue Engineering" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Greg Altman (Tufts University)
"Silk Based Biomaterials for Orthopaedic Tissue Engineered Applications" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | TISSUE ENGINEERING AND OSTEOCHONDRAL REGENERATION: IN SEARCH OF A CELL SOURCE |
| Debate Discussion Leader: Gordana Vunjak-Novakovic (Columbia University) |
| 7:30 pm - 7:40 pm | Gordana Vunjak-Novakovic (Columbia University)
"Introduction" |
| 7:40 pm - 8:05 pm | Frank Barry (National University of Ireland)
"Tissue Repair Strategies Using Undifferentiated Stem Cells" |
| 8:05 pm - 8:30 pm | Rocky Tuan (NIH)
"Tissue Repair Strategies Using Differentiated Stem Cells" |
| 8:30 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TARGETING JOINT REPAIR I - THE SCIENCE: MARKERS, METHODS & THERAPEUTIC APPROACHES |
| Discussion Leader: Robin Poole (Professor Emeritus, McGill University) |
| Therapeutic Opportunities |
| 9:00 am - 9:20 am | Roy Black (Amgen)
"Injected TIMP-3 Protects Cartilage in a Model of Osteoarthritis" |
| 9:20 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Paul Krebsbach (University of Michigan)
"Gene Delivery Strategies for Bone Tissue Engineering" |
| 9:55 am - 10:10 am | Discussion |
| 10:10 am - 10:35 am | Coffee Break |
| Imaging Tissues and Opportunities for Tissue Repair |
| 10:35 am - 10:55 am | Felix Eckstein (Paracelsus Private Medical University)
"Magnetic Resonance Imaging to Assess Joint Structure and its Response to Exercise" |
| 10:55 am - 11:15 am | Timothy Mosher (Pennsylvania State University)
"MRI Techniques for the Study of Cartilage Response to Exercise" |
| 11:15 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Poster 1 |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Poster 2 |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Poster 3 |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | TARGETING JOINT REPAIR II - THE CONTROVERSIES AND NEXT STEPS TOWARD SUCCESS |
| Debate Discussion Leader: David Hart (University of Calgary) |
| 7:30 pm - 8:00 pm | Norimasa Nakamura (Osaka University)
"Can Manipulation of Small Leucine Rich Proteoglycans (Dcn, Bgn) Promote Ligament Healing?" |
| 8:00 pm - 8:30 pm | Christopher Little (University of Sydney)
"Cartilage Repair in OA - The Need to Target Degradative Mechanisms" |
| 8:30 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | KNOCKOUT MODELS FOR UNDERSTANDING REPAIR AND REGENERATION - THE SCIENCE: MARKERS, METHODS & CONSIDERATIONS |
| Discussion Leader: Linda Sandell (Washington University) |
| 9:00 am - 9:50 am | Mark Hamrick (Medical College of Georgia)
"Muscle-Bone Interactions: New Insights From Mouse Models" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:20 am | Karen Lyons (UCLA)
"In Vivo Approaches to Understanding BMP Function in Skeletal Tissues" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:20 pm | Borjana Mikic (Smith College)
"GDF Modulation of Tendon Maintenance and Repair" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THE FUN OF SCIENCE |
| Discussion Leader: Cy Frank (University of Calgary) |
| 7:30 pm - 8:30 pm | Robin Poole (McGill University)
"Cartilage in Health and Disease: Lessons Learned That May Help the Bioengineer" |
| 8:30 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |