Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Biological Genesis of Motion
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"How Is Integrated Tissue Architecture Established? Lessons from Body Axis Elongation in Vertebrates"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Hox Genes Distinguish Long from Short Bones: Origins of the Wrist and Ankle"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Movements in Morphospace: How Are Shape and Variation Generated in the Embryonic Face?"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Energetics and Control
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Muscle Signaling to Other Tissues: Bone and Beyond"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Metabolic Regulation of Skeletal Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Cellular Senescence in Carpal Tunnel Syndrome: Restoring Function and Mobility"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Implications of Cell Senescence for the Aging Skeleton"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Bone and Brain Communications: Regulation of Appetite"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Sensory Nervous System Impact on Subchondral Bone Pathology in a Murine OA Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Organization and Behavior
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Meniscus Morphogenesis: Development in Motion"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Making Cartilage: Lessons (Not) Learned"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Skeletal Stem Cell Contributions to the Mechanoadaptation of Bone: Direct and Indirect Biophysical Regulation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Macrostructural Musculoskeletal Elements
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Functional Adaptation of the Maternal Skeleton to Pregnancy and Lactation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Menisci and Their Ligamentous Attachments in Health and Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Quantifying the Mechanical Environment Throughout Bone Repair: An Implantable Strain Sensor Platform for Non-Invasive Monitoring"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Muscle Force Production Across the Agespan"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Insights into Mechanisms Underlying Spontaneous, Early Onset Intervertebral Disc Degeneration"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Central and Peripheral Neurological Control Systems
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Autonomic Regulation of Bone Remodeling"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Neuropeptide Regulation of Skeletal and Muscular Responses to Altered Energy Balance"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Peripheral Mechanisms of Joint Nociception"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"How Does Joint Injury Lead to Osteoarthritis, Dysfunction and Disability?"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Ectopic Calcification of the Spine: The What, Where and Why of Diffuse Idiopathic Skeletal Hyperostosis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Lifting the Breaks on Bone Shape"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Role of Bone-Derived TGF-Beta on Muscle Function and Glucose Metabolism"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Atrogenes as Common Mediators of Glucocorticoid-Induced Bone and Muscle Atrophy and Weakness"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Targeting Osteogenesis-Angiogenesis Coupling for Bone Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
The Restoration of Musculoskeletal Function
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Bridge-Enhanced ACL Repair: From Concept to Clinical Trial"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Functional Restoration Following Complex Musculoskeletal Trauma"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Biologically Inspired Concepts Guiding Lower-Limb Exoskeleton Design"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Perfecting Musculoskeletal Coordination
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Perfecting Cellular Motion, Promoting Repair"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Use of Regenerative Peripheral Nerve Interfaces for Closed Loop Neural Control of Prosthetics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Functional Integration of a Tissue Engineered Intervertebral Disc and Translation to a Large Animal Model"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"A Gene Therapeutic Approach to Inhibiting Articular Inflammation and Restoring Joint Function"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Biological and Biomechanical Studies of Human Muscle Contractures"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Reconsidering the Origin of the TMJ Articular Disc"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Musculoskeletal System and the Machine
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:45 pm
"Wounded Warfighters Deserve More than a Hook on the End of a Stick: Moving Toward Restoring Form and Function"
8:45 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure