Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Critical Mutagenesis Mechanisms
Discussion Leader: James Haber (Brandeis University, United States)
7:40 pm - 8:20 pm
Susan Lovett (Brandeis University, United States)
"The Genetics of Template-Switch Mutagenesis"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Julian Sale (Medical Research Council Laboratory of Molecular Biology, United Kingdom)
"Genomic Determinants of Mutagenesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication-Fork Associated Mutations
Discussion Leader: Lorraine Symington (Columbia University Irving Medical Center, United States)
9:00 am - 9:20 am
Joseph Loparo (Harvard Medical School, United States)
"Regulating Mutagenesis in Bacteria"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Youri Pavlov (University of Nebraska Medical Center, United States)
"Limits of the Resilience of Yeast Mutasome in Spontaneous and Induced Mutagenesis"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Dmitry Gordenin (National Institute of Environmental Health Sciences, NIH, United States)
"Mutational Motifs Reveal Mechanisms of Mutagenesis in Humans"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Linda Bloom (University of Florida, United States)
"Functional Interactions Between Escherichia Coli Single-Stranded DNA Binding Protein and the Rad3/XPD Family DNA Helicases, YoaA-chi and DinG"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Wei Yang (National Institutes of Health, United States)
"The Intricacy of a DNA Repair Machinery"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michal Dmowski (Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland)
"Helicase-Polymerase Complex in Coordinating DNA Replication with the Cell Cycle, and Shaping Genome Stability in Saccharomyces Cerevisiae"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Nimrat Chatterjee (University of Vermont, United States)
"Translesion Synthesis: Beyond DNA Damage Bypass"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Michael Trakselis (Baylor University, United States)
"Targeted Decoupling of the E. Coli Replisome Induce Cellular and Genomic Stress"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Susan Lovett (Brandeis University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage and Mutagenesis
Discussion Leader: Hannes Lans (Erasmus Medical Center, The Netherlands)
7:30 pm - 7:50 pm
Agnel Sfeir (Memorial Sloan Kettering Cancer Center, United States)
"Developing and Characterizing a Mitochondrial DNA Random Mutator"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Gilad Evrony (New York University Grossman School of Medicine, United States)
"Ultra-High Fidelity Profiling of the Single-Strand Origins of Mutations"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Roger Woodgate (National Institutes of Health, United States)
"Regulation of Highly Mutagenic PolVR391 in Enterobacteriaceae"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Martin Taylor (University of Edinburgh, United Kingdom)
"Multiallelic Variation Shows the Alternate Paths of Translesion Synthesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcription Associated Mutagenesis
Discussion Leader: Juan Carvajal Garcia (Vanderbilt University, United States)
9:00 am - 9:20 am
Andrés Aguilera (CABIMER, University of Seville, Spain)
"New Insights into Chromatin Modification and RNA Metabolism in Genome Integrity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Karlene Cimprich (Stanford University School of Medicine, United States)
"Mechanisms for the Maintenance of Genome Stability"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jason Yang (Rutgers New Jersey Medical School, United States)
"Bioenergetic Stress Potentiates the Evolution of Antimicrobial Resistance"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Philippe Pasero (Institute of Human Genetics / University of Montpellier / CNRS, France)
"Impact of Postreplicative RNA:DNA Hybrids on Replication Fork Stability"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Marco Foiani (IFOM ETS, The AIRC Institute of Molecular Oncology, Italy)
"Topological Mechanisms Mediating Intra and Inter-Chromosomal Interactions"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Oyku Sensoy (Vanderbilt University, United States)
"Asparagine-tRNA Ligase Interacts with R-loops While Regulating Replication upon Severe Conflicts with Transcription"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Influence of DNA Sequence on Mutagenesis
Discussion Leader: Sergei Mirkin (Tufts University, United States)
7:30 pm - 7:50 pm
Mitch McVey (Tufts University, United States)
"POL? and REV1 Promote Preferable Mutagenic Outcomes Following DNA Damage in Drosophila"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Catherine Freudenreich (Tufts University, United States)
"APOBEC Targeting of Trinucleotide Repeats"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Graham Erwin (Baylor College of Medicine, United States)
"Discovering and Targeting Recurrent Repeat Expansions in Human Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jeannine Gerhardt (Weill Cornell Medicine, United States)
"Endogenous and Environmental Factors that Induce Mutations and LOH in Haploinsufficient BRCA1 Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mutagenesis Mechanisms in Cancer
Discussion Leader: Agnel Sfeir (Memorial Sloan Kettering Cancer Center, United States)
9:00 am - 9:20 am
Polina Shcherbakova (Eppley Institute for Research in Cancer and Allied Diseases, United States)
"DNA Polymerase e Mutators in Human Cancers"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
David Pellman (Dana-Farber Cancer Insitute / Harvard Medical School, United States)
"Mechanisms Driving the Rapid Evolution of Cancer Genomes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sangita Choudhury (Boston Children's Hospital, Harvard Medical School, United States)
"Mutational Burden and Landscape of Hypoxic Human Heart Muscle Cell"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Ashby Morrison (Stanford University, United States)
"Regulation of Carcinogen Susceptibility by Nuclear Architecture"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lorraine Symington (Columbia University Irving Medical Center, United States)
"Cas9-Induced Nicks and Double-Strand Breaks Lead to Distinct Mutagenic Outcomes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Puck Knipscheer (Hubrecht Institute, The Netherlands)
"Polymerase Kappa Acts in the Repair of Aldehyde-Induced DNA Interstrand Crosslinks'"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Natalie Saini (Medical University of South Carolina, United States)
"Methylglyoxal-Induced DNA Damage and Mutagenesis in Yeast and Cancers"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Steven Roberts (University of Vermont, United States)
"APOBEC Cytidine Deaminases and UV Light Induce Genetic Alteration in Human Cancers"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
How Exogenous and Endogenous DNA Damage Leads to Mutagenesis
Discussion Leader: Roger Woodgate (National Institutes of Health, United States)
7:30 pm - 7:50 pm
Bevin Engelward (Massachusetts Institute of Technology, United States)
"Analysis of Methylation Damage-Induced Mutations and Clonal Expansion in Mgmt -/- Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Juan Carvajal Garcia (Vanderbilt University, United States)
"The Role of Error-Prone Polymerases in Mutagenesis and Evolution"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
David Rueda (Imperial College London, United Kingdom)
"FANCD2-FANCI is a Sliding Clamp That Surveys DNA and Recognizes ssDNA Gaps"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Bjoern Schwer (University of California, San Francisco, United States)
"Mutagenic Events and DNA Repair in the Contexts of Neurodevelopment and Brain Aging"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kevin Lang (University of Minnesota, United States)
"Maintaining Genomic Integrity During Host-Pathogen Interactions"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Barrier Induced Mutagenesis
Discussion Leader: Catherine Freudenreich (Tufts University, United States)
9:00 am - 9:20 am
Sergei Mirkin (Tufts University, United States)
"Replication Factor Mcm10 Promotes Viability of Cells with Expandable Repeats at a Price of Increasing Their Instability"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Raluca Gordan (Duke University, United States)
"Transcription Factors Increase DNA Mutagenesis by Interfering with the Repair of Replication Errors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Late-Breaking Topic
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Frederic Chedin (University of California, Davis, United States)
"Connecting Splicing Dysfunction to Genome Instability: A Role for R-Loops?"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Nayun Kim (University of Texas at Austin, United States)
"G-Quadruplex-Associated Mutations and Recombinations"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Greg Ngo (Cardiff University, United Kingdom)
"Frequent Template Switching During Mitosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
James Haber (Brandeis University, United States)
"Mutations Arising During Homologous Recombinational Repair of a Chromosome Break"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Ultimate Consequences of Mutations and Evolution
Discussion Leader: Kevin Lang (University of Minnesota, United States)
7:30 pm - 7:50 pm
Daniel Jarosz (Stanford University, United States)
"Single Aggregation-Prone Proteins and Their Role in Tolerating Accumulating Mutation Burden in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Megan Behringer (Vanderbilt University, United States)
"Environmental and Epigenetic Influences on Mutation Rate Evolution"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sarah Fortune (Harvard T.H. Chan School of Public Health, United States)
"Drivers of Mutation in Mycobacterium Tuberculosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Hannes Lans (Erasmus Medical Center, The Netherlands)
"Persistent DNA Repair Intermediates Cause Cell and Developmental Failure"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure