Saturday
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1:00 pm - 5:00 pm |
Arrival and Check-in
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3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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3:45 pm - 4:30 pm |
Keynote Session: The Mutational Footprints of Cancer Therapies
Discussion Leader: Daniel Pers (Vanderbilt University, United States)
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3:45 pm - 3:50 pm |
Introduction by Discussion Leader
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3:50 pm - 4:25 pm |
Nuria Lopez-Bigas (IRB Barcelona, Spain)
"The Mutational Footprints of Cancer Therapies"
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4:25 pm - 4:30 pm |
Discussion
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
DNA Structure Promoted Mutagenesis
Six student/postdoc talks chosen from the abstracts
Discussion Leader: Jasmina Büchel (ETH Zurich, Switzerland)
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7:30 pm - 7:45 pm |
Kaitlynne Bohm (Washington State University, United States)
"Genome-Wide Maps of Rare UV Photoproducts Reveal Distinct Patterns of DNA Damage Formation in Chromatin"
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7:45 pm - 7:50 pm |
Discussion
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7:50 pm - 8:05 pm |
Chiara Masnovo (Tufts University, United States)
"Coordination Between Leading and Lagging Strand Synthesis Prevents GAA Repeat Instability"
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8:05 pm - 8:10 pm |
Discussion
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8:10 pm - 8:25 pm |
Rebecca Brown (Tufts University, United States)
"THO and TRAMP Complexes Prevent Transcription-Replication Conflicts, DNA Breaks, and CAG Repeat Contractions"
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8:25 pm - 8:30 pm |
Discussion
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8:30 pm - 8:45 pm |
Daniel Pers (Vanderbilt University, United States)
"Investigating the Mechanisms Behind R-Loop Induced Lethality upon Replication-Transcription Conflicts"
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8:45 pm - 8:50 pm |
Discussion
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8:50 pm - 9:05 pm |
MaryElizabeth Stein (Penn State College of Medicine, United States)
"The Significance of G-Quadruplex Variation to Mutagenesis: Sequence and Topology Differentially Impact Human DNA Polymerase Fidelity"
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9:05 pm - 9:10 pm |
Discussion
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9:10 pm - 9:25 pm |
Diane Shao (Boston Children's Hospital, United States)
"Duplex Consensus Sequencing for Accurate Detection of Somatic Mutations in the Human Fetal Brain"
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9:25 pm - 9:30 pm |
Discussion
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Sunday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 11:00 am |
Enzyme Promoted Mutagenesis
Six student/postdoc talks chosen from the abstracts
Discussion Leader: Chiara Masnovo (Tufts University, United States)
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9:00 am - 9:15 am |
Ryan Campbell (Florida State University , United States)
"Mechanistic Description of Metabolic Adaptation via Enzyme Recruitment"
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9:15 am - 9:20 am |
Discussion
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9:20 am - 9:35 am |
Kara Pytko (Pennsylvania State University, United States)
"Characterization of Human DNA Polymerase Delta-Mediated Replication of a Difficult-to-Replicate-Sequence"
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9:35 am - 9:40 am |
Discussion
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9:40 am - 9:55 am |
Daria Ostroverkhova (Queen's University, Canada)
"Specific Patterns of Mutations Induced by Mutated DNA Polymerase Epsilon in Endometrial Cancer Genomes"
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9:55 am - 10:00 am |
Discussion
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10:00 am - 10:15 am |
Juan Carvajal Garcia (Vanderbilt University, United States)
"Oxidative Damage Makes Nucleotide Excision Repair Mutagenic"
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10:15 am - 10:20 am |
Discussion
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10:20 am - 10:35 am |
Anna Johnson (Vanderbilt University, United States)
"A Small Molecule that Inhibits the Evolution of Antibiotic Resistance"
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10:35 am - 10:40 am |
Discussion
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10:40 am - 10:55 am |
Savannah Weeks-Pollenz (University of Florida , United States)
"Escherichia coli Single-Stranded DNA Binding Protein Inhibits the Helicase Activity of the XPD/Rad-3 like Helicase, DinG, on Duplex DNA Substrates"
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10:55 am - 11:00 am |
Discussion
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11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 2:30 pm |
Mentorship Component: Got a PhD - What Awaits You After?
Discussion Leaders: Savannah Weeks-Pollenz (University of Florida , United States)
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1:30 pm - 2:30 pm |
Panel Discussion
A Glimpse into the Diverse World of Scientific Careers Following Higher Education
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Sue Jinks-Robertson (Duke University Medical Center, United States)
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Houra Merrikh (Vanderbilt University, United States)
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Shana Sturla (ETH Zurich, Switzerland)
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Charles Valentine (TwinStrand Biosciences, Inc., United States)
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2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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3:00 pm |
Seminar Concludes
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