Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: DNA Damage, Repair, and Mutations in the Context of Environmental Health
Discussion Leader: Savannah Weeks-Pollenz (University of Florida , United States)
3:45 pm - 4:20 pm
Bevin Engelward (Massachusetts Institute of Technology, United States)
"Impact of DNA Damage and Repair on Outcomes from Environmental Exposures"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Causes of Genomic Alterations
Discussion Leader: Elijah Newcomb (University of Florida, United States)
7:30 pm - 7:40 pm
Marian Laughery (Washington State University, United States)
"The Global Genomic Landscape of Cytosine Deamination of CPDs in UV-Irradiated S. Cerevisiae is Influenced by Sequence and Chromatin Contexts"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Thomas Blouin (Medical University of South Carolina, United States)
"Investing the Roles of Translesion Synthesis and DNA-Protein Crosslink Repair in Altering Formaldehyde-Induced Mutagenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Salome Jingchen Zhao (University of Cambridge, United Kingdom)
"Mutational Footprints of DNA Damage and Repair in Homologous Deficient Human Cells"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Cameron Cordero (University of Vermont, United States)
"Unraveling the Pathways of 8-oxodG Mutagenesis and Repair Mechanisms in Human Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Cameron Durfee (University of Texas Health, San Antonio, United States)
"Mutational Synergy Between the DNA Deaminase APOBEC3B and the Chemical Carcinogen 4-NQO In Vivo"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Benjamin Finander (Harvard University, United States)
"Neuronal Somatic Mutations Associated with Maternal Immune Activation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Matthew Johnson (Columbia University, United States)
"Analyzing the Mutagenic Potential of Cas9 Nickases"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Archana Krishnamoorthy (Dana Farber Cancer Institute / Harvard Medical School, United States)
"Mechanisms of Chromosome Fragmentation in Mitosis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Consequences and Repair of Genomic Alterations
Discussion Leader: Mary-Anne Durin (University of Oxford, United Kingdom)
9:00 am - 9:10 am
Savannah Weeks-Pollenz (University of Florida , United States)
"SSB Hitches a Ride with the YoaA-chi Helicase"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Victor Corral (University of Minnesota, Twin Cities, United States)
"Deciphering a Phosphorylation Circuitry of RNase H1 in R-Loop Regulation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Aeverie Heuchan (United Kingdom Dementia Research Institute, Cardiff University, United Kingdom)
"FAN1 Prevents CRISPR-Cas9 Nickase-Induced Contractions of CAG/CTG Repeats"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Elodie Bournique (University of California, Irvine, United States)
"ATM and IRAK1 Orchestrate Two Distinct Mechanisms of NF-kB Activation in Response to DNA Damage"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Mihyun Kim (IBS Center for Genome Integrity / UNIST, South Korea)
"Structural, Biochemical, and Cellular Studies of the Interaction of XPG with TFIIH in NER"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Joshua Victor (University of Vermont, United States)
"Increased Host Genome Instability and SARS-CoV-2 Pathogenesis"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Prabha Verma (National Institute of Plant Genome Research, India)
"Deciphering the Structural and Biochemical Insights of At-HIGLE: A GIY-YIG Superfamily Protein in Arabidopsis thaliana"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Michael Nicholson (University of Edinburgh, United Kingdom)
"DNA Lesion Bypass and the Stochastic Dynamics of Transcription Coupled Repair"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Scientific Career Questions
Discussion Leader: Alyssa Hurley (University of Vermont, United States)
1:30 pm - 2:30 pm
Panel Discussion
Scientific Career Questions
Bevin Engelward (Massachusetts Institute of Technology, United States)
Karlene Cimprich (Stanford University School of Medicine, United States)
Julian Sale (Medical Research Council Laboratory of Molecular Biology, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes