Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Viruses, Cancer and Stem Cell
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Why Do Viruses Cause Cancer?"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Normal and Neoplastic Stem Cells"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
EBV Infection and NPC Pathogenesis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"EBV Genome Sequence Variation: Geography, Function and Disease"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"How EBV Prevails During Productive Infection"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Regulation of Host Signaling Pathways by EBV miRNAs"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"NPC Epigenetic Landscapes and Super-Enhancers"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Nasopharyngeal Carcinoma Susceptibility Gene TNFRSF19 Inhibits TGFβ Signaling and Promotes Tumorigenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Genome Sequencing Analysis Identifies Epstein-Barr Virus Subtypes Associated with the Risk of Nasopharyngeal Carcinoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Lytic and Latent EBV Infection
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Differentiation-Dependent Lytic EBV Reactivation in Epithelial Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"New Functions for EBV Proteins in Manipulating Cellular Processes Important for Cancer"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Key Cellular Factors in EBV Infection of Epithelial Cells"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Risk Factors and Novel Markers for NPC
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genetic Predisposition of Nasopharyngeal Carcinoma: Evidence from GWAS and Sequencing Studies"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Application of Plasma EBV DNA Assay in Daily Practice of NPC Management"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
"Plasma EBV DNA for Screening Nasopharyngeal Carcinoma"
10:35 am - 10:45 am
Discussion
10:45 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
"New Insights in NPC Detection Utilizing Circulating Tumor Cell Enumeration and NGS Analysis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Circulating Tumor DNA: Detection and Applications in Curable Cancers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Molecular Profiling of NPC
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:25 pm
"Acquired Genomic Changes in Nasopharyngeal Carcinoma"
4:25 pm - 4:35 pm
Discussion
4:35 pm - 4:55 pm
"Genetic Susceptibility in Nasopharyngeal Carcinoma"
4:55 pm - 5:05 pm
Discussion
5:05 pm - 5:35 pm
"Translational Aspects of DNA Methylation in Cancer"
5:35 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"The M81 Epstein-Barr Virus Associated RNA2 Enhances CXCL8 Production and Spontaneous Virus Lytic Replication in Primary B Lymphocytes"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Microenvironment of NPC
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Galectin-9 and Other Factors of Immune Escape in NPC Tumor Microenvironment: How to Bring Them Under Control?"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"A Role of Bacterial Co-Infection in the Pathogenesis of NPC?"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"A Novel Mechanism of Induction of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-Positive Epithelial Malignancies Through Intracellular Iron Chelation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Are Exposure to Sunlight, Dietary Vitamin D Intake, Serum and Genetically Derived 25-Hydroxyvitamin D Risk Factors of Nasopharyngeal Carcinoma (NPC)?"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"ISNLx Regulates Cellular Metabolic Reprogramming and Is a Potential Therapeutic Target for Nasopharyngeal Carcinoma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Epstein-Barr Virus-Encoded LMP1 Reprograms Glucose Metabolism to Drive Cell Motility Through mTORC2/PDHE1α-Mediated Histone Acetylation in Nasopharyngeal Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"NPC Strip G: Rapid Test Strip Detecting IgG Against EBV Antigens in NPC"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Challenges and Novel Approaches in NPC Treatment
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Role of Chemotherapy in NPC: Not Novel, but Still Challenging"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Comprehensive Treatment Strategy in Locoregionally Advanced Nasopharyngeal Carcinoma"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Challenges and Novel Approaches in Radiotherapy for Nasopharyngeal Carcinoma"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Development of an EBNA1 Inhibitor for the Treatment of NPC: Toward First-in-Human Studies"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Immune and Other Biomarkers of Resistance to Anti-PD1 Therapy in NPC"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Adoptive T Cell Therapy for NPC: Immune Correlates to Immune Contexture"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The NPC Immunotherapy Landscape"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Cellular Immunotherapy for Nasopharyngeal Cancer: Learning from the Past for a Better Tomorrow"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Immune Checkpoint Inhibitor in the Treatment of Nasopharyngeal Carcinoma: A Clinical Overview"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Keynote Session: Future Perspectives in NPC Research and Treatment
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:45 pm
"Beyond Targeting Oncogenes: Future Anti-Cancer Strategies"
4:45 pm - 5:00 pm
Discussion
5:00 pm - 5:40 pm
"The Future of NPC Research: Opportunities and Challenges"
5:40 pm - 5:55 pm
Discussion
5:55 pm - 6:00 pm
Closing Remarks
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure