Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						 
						 
					
						
						
7:40 pm - 9:30 pm 
	
Keynote Session: The Chemistry Biology Interface 
 
 
 
						 
						 
					
						
						
7:40 pm - 8:20 pm 
	
"Chemical Probes Uncover a New Anti-Bacterial Strategy" 
 
 
 
						 
						 
					
						
						
8:20 pm - 8:35 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:35 pm - 9:15 pm 
	
"Hijacking Molecular Machines to Reveal New Chemistry and New Biology" 
 
 
 
						 
						 
					
						
						
9:15 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Early Career Investigator Presentations 
 
 
 
						 
						 
					
						
						
9:00 am - 9:20 am 
	
"New Avenues in Cyclase Phase Total Synthesis" 
 
 
 
						 
						 
					
						
						
9:20 am - 9:25 am 
	
Discussion
 
 
						 
						 
					
						
						
9:25 am - 9:45 am 
	
"Biosynthesis of Natural and New-to-Nature Glycosides in Engineered Yeast" 
 
 
 
						 
						 
					
						
						
9:45 am - 9:50 am 
	
Discussion
 
 
						 
						 
					
						
						
9:50 am - 10:10 am 
	
"Novel Strategies for Complex Bioactive Molecule Synthesis" 
 
 
 
						 
						 
					
						
						
10:10 am - 10:15 am 
	
Discussion
 
 
						 
						 
					
						
						
10:15 am - 10:45 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:45 am - 11:05 am 
	
"Synthesis of Amino Acid-Derived Natural Products" 
 
 
 
						 
						 
					
						
						
11:05 am - 11:10 am 
	
Discussion
 
 
						 
						 
					
						
						
11:10 am - 11:30 am 
	
"Total Synthesis of Sulfur-Containing Sesquiterpenoid Natural Products" 
 
 
 
						 
						 
					
						
						
11:30 am - 11:35 am 
	
Discussion
 
 
						 
						 
					
						
						
11:35 am - 11:55 am 
	
"Efficient Natural Product Synthesis via a Common Polyfunctional Building Block Approach" 
 
 
 
						 
						 
					
						
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:00 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Medicinal Chemistry of Natural Products and Bioactive Compounds 
 
 
 
						 
						 
					
						
						
7:30 pm - 8:00 pm 
	
"Adventures in Chemistry: Drugging KRAS Past and Present" 
 
 
 
						 
						 
					
						
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:10 pm - 8:40 pm 
	
"Prodrugs to the Rescue: The Discovery of a Potent eIF2B Activator Clinical Candidate" 
 
 
 
						 
						 
					
						
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:20 pm 
	
"Structure-Based Discovery of Potent Sialic Acid Analogs Targeting Siglec3" 
 
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Biosynthesis and Biotechnology Related to Natural Products 
 
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"Biosynthesis of Unusual Molecules by Opportunistic Pathogens" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:40 am 
	
Discussion
 
 
						 
						 
					
						
						
9:40 am - 10:10 am 
	
"Discovery of New Natural Product from Fungi using Genome-Based Approaches" 
 
 
 
						 
						 
					
						
						
10:10 am - 10:20 am 
	
Discussion
 
 
						 
						 
					
						
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:50 am - 11:20 am 
	
"Discovery and Engineering of Plant Natural Product Pathways" 
 
 
 
						 
						 
					
						
						
11:20 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 12:00 pm 
	
"Stereoselective Pyridoxal Radical Biocatalysis for Diversity-Oriented Synthesis" 
 
 
 
						 
						 
					
						
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Process Chemistry Toward Complex Bioactive Compounds 
 
 
 
						 
						 
					
						
						
7:30 pm - 8:00 pm 
	
"Development of a Commercial Manufacturing Process for Vepdegestrant, an Orally Bioavailable PROTAC Estrogen Receptor Degrader" 
 
 
 
						 
						 
					
						
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:10 pm - 8:40 pm 
	
"Pivoting to Catalysis for Kilo Scale API Deliveries" 
 
 
 
						 
						 
					
						
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:20 pm 
	
"Process Chemistry Toward Complex Bioactive Compounds" 
 
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Total Synthesis of Complex Natural Products 
 
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"Synthetic Studies Toward Complex Natural Products" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:40 am 
	
Discussion
 
 
						 
						 
					
						
						
9:40 am - 10:10 am 
	
"Tactic Combinations for the Synthesis of Complex Natural Products with Important Biological Activities" 
 
 
 
						 
						 
					
						
						
10:10 am - 10:20 am 
	
Discussion
 
 
						 
						 
					
						
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:50 am - 11:20 am 
	
"Computationally Augmented Total Synthesis" 
 
 
 
						 
						 
					
						
						
11:20 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 12:00 pm 
	
"Primary and Secondary Metabolites as Inspiration for Synthesis" 
 
 
 
						 
						 
					
						
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Synthetic Methods for Construction and Modification of Biologically Important Molecules 
 
 
 
						 
						 
					
						
						
7:30 pm - 8:00 pm 
	
"New Concepts for Atom and Functional Group Transfer" 
 
 
 
						 
						 
					
						
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:10 pm - 8:40 pm 
	
"Chemical Synthesis as a Tool for Discovery: Targeting Bioactivity Through Natural Product Design" 
 
 
 
						 
						 
					
						
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:20 pm 
	
"New Synthetic Methods Using Photochemistry" 
 
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s) 
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Strategies and Tactics for Rapid Construction of Chemical Complexity 
 
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"Exploring Ring Transformations: Opening, Formation, and Swapping of Cyclic Structures" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:40 am 
	
Discussion
 
 
						 
						 
					
						
						
9:40 am - 10:10 am 
	
"Creating Confined Spaces: Supramolecular Lewis Acid-Base Catalysis for Unlocking New Reactivities in Terpene Cyclizations" 
 
 
 
						 
						 
					
						
						
10:10 am - 10:20 am 
	
Discussion
 
 
						 
						 
					
						
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:50 am - 11:20 am 
	
"Simplicity and Complexity: Photochemistry as an Enabling Tool" 
 
 
 
						 
						 
					
						
						
11:20 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 12:00 pm 
	
"Natural Product Synthesis With Designed Hydrocarbons" 
 
 
 
						 
						 
					
						
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Keynote Session: Synthesis and Biosynthesis of Complex Natural Products 
 
 
 
						 
						 
					
						
						
7:30 pm - 8:15 pm 
	
"Genome Mining for New Chemistry" 
 
 
 
						 
						 
					
						
						
8:15 pm - 8:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:30 pm - 9:15 pm 
	
"Discovery and Surprises with Natural Products" 
 
 
 
						 
						 
					
						
						
9:15 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am 
	
Departure