Evolving Understandings of the Molecular Players in Neuroepigenetics

This inaugural GRC will convene leading scientists to explore the molecular underpinnings of epigenetic regulation in the nervous system. With rapid advances in single-cell sequencing, spatial transcriptomics/epigenomics, genome editing, and high-resolution imaging, we are now poised to dissect the precise molecular players, DNA and histone modifiers, chromatin remodelers, noncoding RNAs, and associated signaling pathways that orchestrate neural development, plasticity, and disease. Understanding how these components interact across diverse model systems is essential for bridging fundamental mechanisms with translational potential, particularly in the context of neurodevelopmental and neuropsychiatric disorders. By highlighting these molecular drivers, this meeting will catalyze new insights, foster interdisciplinary collaboration, and inspire the next generation of researchers to tackle the most pressing challenges in neuroepigenetics.